Results 161 to 170 of about 74,786 (193)

Discovery of a distinct binding site for angiotensin II (3–8), a putative angiotensin IV receptor

Regulatory Peptides, 1992
We report here the discovery of a unique and novel angiotensin binding site and peptide system based upon the C-terminal 3-8 hexapeptide fragment of angiotensin II (NH3(+)-Val-Tyr-Ile-His-Pro-Phe-COO-) (AII(3-8) (AIV)). This fragment binds saturably, reversibly, specifically, and with high affinity to membrane-binding sites in a variety of tissues and ...
Geoffrey N. Swanson, Jodie M. Hanesworth, Michael F. Sardinia, John K.M. Coleman, John W. Wright, Keith L. Hall, Allison V. Miller-Wing, Jeffrey W. Stobb, Victoria I. Cook, Erin C. Harding, Joseph W. Harding   +10 more
openaire   +2 more sources

Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor

Peptides, 2011
Angiotensin II (Ang II) is an important regulator of cardiac function and injury in hypertension. The novel Ang IV peptide/AT4 receptor system has been implicated in several physiological functions and has some effects opposite to those of Ang II. However, little is known about the role of this system in Ang II-induced cardiac injury.
Hui, Yang, Xiang-Jun, Zeng, Hong-Xia, Wang, Li-Ke, Zhang, Xiao-Li, Dong, Shubin, Guo, Jie, Du, Hui-Hua, Li, Chao-Shu, Tang   +8 more
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From angiotensin IV binding site to AT4 receptor

Molecular and Cellular Endocrinology, 2009
One of the fragments of the cardiovascular hormone Angiotensin II incited the interest of several research groups. This 3-8 fragment, denoted as Angiotensin IV (Ang IV) causes a number of distinct biological effects (see Introduction), unlikely to be explained by its weak binding to AT(1) and/or AT(2) receptors. Moreover the discovery of high affinity [
openaire   +3 more sources

Analysis of responses to angiotensin IV in the pulmonary vascular bed of the cat

European Journal of Pharmacology, 1994
Responses to angiotensin IV were investigated and compared with responses to angiotensin II in the pulmonary vascular bed of the intact-chest cat under constant flow conditions. Under low resting tone conditions, intralobar injections of angiotensin IV caused dose-related increases in lobar arterial pressure.
D Y, Cheng, B J, DeWitt, E L, Dent, B D, Nossaman, P J, Kadowitz   +4 more
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Drinking to intracerebroventricularly infused angiotensin II, III, and IV in the SHR

Peptides, 1988
Spontaneously hypertensive rats (SHR) revealed exaggerated water consumption to the intracerebroventricular (ICV) infusion of angiotensin II (AII), and angiotensin III (AIII), as compared with Wistar-Kyoto (WKY) and Sprague-Dawley (SD) normotensive rat strains, in agreement with an earlier report (30) that employed ICV bolus injections of AII and AIII.
J W, Wright, K A, Roberts, J W, Harding
openaire   +2 more sources

A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat

Peptides, 2001
Angiotensin II (AngII) or Angiotensin IV (AngIV) was infused into the renal artery of anesthetized rats while renal cortical blood flow was measured via laser Doppler flowmetry. The infusion of AngII produced a significant elevation in mean arterial pressure (MAP) with an accompanying decrease in cortical blood flow, glomerular filtration rate (GFR ...
T A, Hamilton, R K, Handa, J W, Harding, J W, Wright   +3 more
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Involvement of angiotensin II and angiotensin IV in producing the individual characteristics of defensive and feeding behavior in rats

Neuroscience and Behavioral Physiology, 2008
The involvement of angiotensin II and angiotensin IV in defensive (the tail-flick test) and acquired feeding behavior in rats was studied. Angiotensin II had a greater role than angiotensin IV in feeding behavior in rats. Angiotensin IV had a greater effect than angiotensin II on the defensive behavior of individuals.
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Biphasic actions of angiotensin IV on renal blood flow in the rat

Regulatory Peptides, 2006
Our aim was to investigate the changes in renal blood flow during brief exposure of the renal vasculature to angiotensin IV (Ang IV). Total renal blood flow was measured by electromagnetic flowmetry in pentobarbital-anesthetized male Sprague Dawley rats. Intrarenal injection of Ang I, Ang II and Ang III produced a dose-dependent vasoconstriction.
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The renin–angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts

Kidney International Supplements, 2022
CARLOS M Ferrario, Leanne Groban, Xuming Sun   +2 more
exaly  

Angiotensin II analogs. IV. Synthesis and biological evaluation of simplified angiotensins

Journal of Medicinal Chemistry, 1970
E C, Jorgensen, G C, Windridge, T C, Lee
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