Results 21 to 30 of about 444,347 (295)

Search for angiotensin II receptor antagonists among 4-aryl-n-(aryl)-3-(prop-2-en-1-yl)-2,3-dihydro-1,3-thiazol-2-imine derivatives [PDF]

Pharmacia, 2019
The aim of study was to find potential antihypertensive and cardiotropic drugs among new 4-aryl-N-(aryl)-3-(prop-2-en-1-yl)-2,3-dihydro-1,3-thiazol-2-imines.
Iryna Drapak, Borys Zimenkovsky, Lina Perekhoda, Мargarita Suleyman, Hanna Yeromina, Natalia Skaletska, Natalya Seredynska, Anatoly Demchenko   +7 more
doaj   +3 more sources

Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Guideline‐directed medical therapy (GDMT) improves outcomes in heart failure irrespective of frailty status. Nevertheless, the magnitude of frailty‐associated discontinuation of GDMT remains insufficiently studied.
Ryo Nakamaru, Shiori Nishimura, Hiraku Kumamaru, Kyohei Daigo, Kayo M. Walsh, Shun Kohsaka   +5 more
doaj   +1 more source

Tetrazole and Carboxylate Groups of Angiotensin Receptor Antagonists Bind to the Same Subsite by Different Mechanisms (*)

Journal of Biological Chemistry, 1995
To identify specific interactions between either the tetrazole or carboxylate pharmacophores of non-peptide antagonists and the rat AT1 receptor, 6 basic residues were examined by site-directed mutagenesis.
Keita Noda, Y. Saad, A. Kinoshita, Thomas P. Boyle, R. Graham, A. Husain, S. Karnik   +6 more
semanticscholar   +1 more source

Synthetic nanobodies as angiotensin receptor blockers

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The G protein-coupled receptor (GPCR) family is responsible for regulating much of human physiology, and GPCRs have become the most successful target class for drug development.
Conor McMahon, D. Staus, L. Wingler, Jialu Wang, M. Skiba, Matthias Elgeti, W. Hubbell, H. Rockman, A. Kruse, R. Lefkowitz   +9 more
semanticscholar   +1 more source

The Use of Dried Blood Spots for the Quantification of Antihypertensive Drugs

International Journal of Analytical Chemistry, 2018
Hypertension or high blood pressure is a harbinger of cardiovascular diseases. There are several classes of drugs used to treat hypertension. This review discusses the use of dried blood spots (DBSs) for the quantification by mass spectrometry (MS ...
Alexander Chernonosov
doaj   +1 more source

THE EFFICACY OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANTAGONISTS OF THE RECEPTORS OF THE 1ST TYPE OF ANGIOTENSIN II IN PATIENTS WITH CORONARY ARTERY DISEASE POSTINFARCTION CARDIOSCLEROSIS COMBINED WITH DIABETES MELLITUS TYPE 2 AND ARTERIAL HYPERTENSION

В мире научных открытий, 2016
The article discusses the effectiveness of 3-month therapy with angiotensin converting enzyme inhibitors fosinopril receptor and antagonists of the angiotensin II valsartan to achieve target BP(
Zarina Vyacheslavovna Bitarovа, Oleg Valeryevich Remizov, Zamira Tatarbekovna Astakhova, Zalina Aslanbekovna Toguzova   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Risk Factors, Use of Preventive Drugs, and Cardiovascular Events in Diabetes Mellitus: The PURE Türkiye Cohort

Anatolian Journal of Cardiology, 2023
Background: The risk of cardiovascular disease is correlated with the frequency and control of associated risk factors in diabetes mellitus and may vary according to country.
Aytekin Oğuz, Mustafa Kılıçkap, Sadi Guleç, Yüksel Altuntaş, Kubilay Karşıdağ, Ahmet Temizhan, Özge Telci Çaklılı, Kevser Burcu Tümerdem Çalık, Miraç Vural Keskinler, Sumathy Rangarajan, Salim Yusuf   +10 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Efficacy of low-dose spironolactone on top of angiotensin receptor blockade in patients with glomerulonephritis

Kidney Research and Clinical Practice, 2018
Background: Previous studies have shown that aldosterone antagonists have a proteinuria-lowering effect in patients with proteinuria and progressive proteinuric disease not adequately controlled by the use of angiotensin receptor blockers (ARBs ...
Byung Chul Yu, Min Sung Lee, Jong Joo Moon, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, Moo Yong Park   +6 more
doaj   +1 more source