Results 21 to 30 of about 358,234 (380)
Search for angiotensin II receptor antagonists among 4-aryl-n-(aryl)-3-(prop-2-en-1-yl)-2,3-dihydro-1,3-thiazol-2-imine derivatives [PDF]
Pharmacia, 2019 The aim of study was to find potential antihypertensive and cardiotropic drugs among new 4-aryl-N-(aryl)-3-(prop-2-en-1-yl)-2,3-dihydro-1,3-thiazol-2-imines.
Iryna Drapak +7 more
doaj +3 more sources
Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]
PLoS Comp. Biol. (2015) 11(2): e1004044, 2014 Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the structural and dynamical origin of ligand-dependent modulation of GPCR activity, we performed total $\sim$ 5 $\mu$sec molecular dynamics simulations of A$_{2A}$ adenosine ...
arxiv +1 more source
The Angiotensin II AT2 Receptor Is an AT1Receptor Antagonist [PDF]
Journal of Biological Chemistry, 2001 The vasopressor angiotensin II activates AT(1) and AT(2) receptors. Most of the known in vivo effects of angiotensin II are mediated by AT(1) receptors while the biological functions of AT(2) receptors are less clear. We report here that the AT(2) receptor binds directly to the AT(1) receptor and thereby antagonizes the function of the AT(1) receptor ...
Ahmed M. Abdel-tawab +3 more
openaire +3 more sources
Clinical Cardiology, Volume 45, Issue 12, Page 1171-1183, December 2022., 2022 Abstract Radial artery spasm (RAS) is the most common cause of transradial access site crossover and is a common intra‐procedural complication. RAS incidence can lead to radial artery occlusion (RAO) postprocedure, preventing the radial artery as a future access site.
Basel Abdelazeem +8 more
wiley +1 more source
PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY
Рациональная фармакотерапия в кардиологии, 2017 The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved
O. M. Drapkina, D. U. Akasheva
doaj +1 more source
Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]
J Cell Biochem (2021) 1-8, 2020 The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv +1 more source
Clinical Experience With Angiotensin II Receptor Antagonists [PDF]
American Journal of Hypertension, 1992 This series of studies was designed to assess in normal volunteers the relationships between various doses (5, 10, 20, 40, 80, and 120 mg) of the orally active angiotensin II antagonist losartan (DuP 753, MK-954) and their inhibitory effect on the pressure response to a given bolus of angiotensin I or II. It was found that the maximal inhibitory effect
Brunner, Hans R. +5 more
openaire +3 more sources
Clinical Cardiology, Volume 45, Issue 12, Page 1163-1170, December 2022., 2022 Abstract The implantable cardiac defibrillator (ICD) is common for the management of nonischemic cardiomyopathy (NICM). Mortality is a crucial issue for patients with NICM. We can understand the mortality events of ICD versus medicine treatment via a systemic review and meta‐analysis of randomized clinical trials.
Wenfeng He +3 more
wiley +1 more source
Anesthesia and Analgesia, 1999 An increasing number of patients scheduled for surgery are chronically treated with angiotensin II receptor antagonists (ARA). These drugs interfere with the renin-angiotensin system by inhibiting the angiotensin II (AII) binding to its receptor ...
S. Brabant +3 more
semanticscholar +1 more source
A remote hypertension management program clinical algorithm
Clinical Cardiology, Volume 45, Issue 12, Page 1147-1162, December 2022., 2022 Abstract Introduction Hypertension is the leading risk factor for death, affecting over one billion people worldwide, yet control rates are poor and stagnant. We developed a remote hypertension management program that leverages digitally transmitted home blood pressure (BP) measurements, algorithmic care pathways, and patient–navigator communications ...
Hunter Nichols +3 more
wiley +1 more source