Results 171 to 180 of about 28,097 (222)

Structure of Human Angiotensinogen Gene

DNA, 1989
A cDNA clone encoding human angiotensinogen was isolated from a cDNA library prepared from human liver mRNA and used to isolate the angiotensinogen gene. The complete exon sequence of this gene together with extensive intron and flanking sequences are reported. The human angiotensinogen gene contains five exons interrupted by four intervening sequences.
Gaillard, Isabelle, Clauser, E., Corvol, P.   +2 more
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Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease

American Heart Journal, 1999
Genes encoding components of the renin-angiotensin system have been associated with elevated blood pressure (BP) and an increased risk of coronary artery disease. To explore the role of the angiotensinogen (AGT) gene in coronary atherosclerosis and thrombosis, we studied the effect of the AGT M235T gene variant on plasma AGT levels and BP in patients ...
Winkelmann, Bernhard R., Russ, Andreas P., Nauck, Markus S., Klein, Bärbel, Böhm, Bernhard Otto, Maier, Volker, Zotz, Rainer Bernd, Matheis, Georg, Wolf, Andreas, Wieland, Heinrich, Groß, Werner, Galton, David J., März, Winfried   +12 more
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Angiotensinogen in chronic liver disease

Scandinavian Journal of Clinical and Laboratory Investigation, 1992
The renin substrate angiotensinogen (AGT) belongs to a supergene family of proteins that also includes alpha 1-antitrypsin (AAT) and alpha 1-antichymotrypsin (ACT), acute-phase reactants with known serine proteinase inhibitory (serpin) function. AGT lacks a known inhibitory function but is an acute-phase reactant.
K, Sjöberg, R, Alm, S, Eriksson
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Hyperglycemia modulates angiotensinogen gene expression

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2001
Elevated plasma angiotensinogen (AGT) levels have been demonstrated in insulin-resistant states such as obesity and type 2 diabetes mellitus (DM2), conditions that are directly correlated to hypertension. We examined whether hyperinsulinemia or hyperglycemia may modulate fat and liver AGT gene expression and whether obesity and insulin resistance are ...
I, Gabriely, X M, Yang, J A, Cases, X H, Ma, L, Rossetti, N, Barzilai   +5 more
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Angiotensinogen in Human Essential Hypertension

Hypertension, 1996
The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent ...
M, Caulfield, P, Lavender, J, Newell-Price, S, Kamdar, M, Farrall, A J, Clark   +5 more
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Rescue of Angiotensinogen-Knockout Mice

Biochemical and Biophysical Research Communications, 1998
Angiotensinogen, the precursor of angiotensins I and II, is a critical component of the renin-angiotensin system that plays an important role in regulating blood pressure and electrolyte homeostasis. Genetically altered mice lacking angiotensinogen (Agt-KO) showed an expected phenotype, such as marked hypotension, but unexpected ones including abnormal
J, Ishida, F, Sugiyama, K, Tanimoto, K, Taniguchi, M, Syouji, E, Takimoto, H, Horiguchi, K, Murakami, K i, Yagami, A, Fukamizu   +9 more
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Hormonal control of angiotensinogen production

Life Sciences, 1982
The renin-angiotensin-aldosterone system appears to be under neural and hormonal control. Plasma angiotensinogen concentration is elevated in Cushing's disease, during pregnancy and in women taking oral contraceptives. An in vitro liver slice system was used to study the hormonal control of angiotensinogen synthesis and release in the rat ...
V J, Dzau, H C, Herrmann
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Angiotensinogen variants and human hypertension

Current Hypertension Reports, 1999
The research on molecular genetics of human hypertension aims to identify the loci involved in the regulation of blood pressure, detect gene variants within the identified loci, associate them with intermediate phenotypes, and ultimately estimate their quantitative effects on blood pressure level and their interaction with main environmental factors ...
X, Jeunemaitre, A P, Gimenez-Roqueplo, J, Célérier, P, Corvol   +3 more
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Oestrogenic Regulation Of Brain Angiotensinogen

Journal of Neuroendocrinology, 2004
AbstractOestrogens are now recognized as playing a regulatory role on components of the systemic renin–angiotensin system, such as its precursor, angiotensinogen (AGT). In the brain, this role is poorly understood. The aim of this study was to investigate the influence of oestrogens on brain AGT of female rats at different stages of the oestrous cycle,
Greenland, K. J., Sernia, C.
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Astrocytes Synthesize Angiotensinogen in Brain

Science, 1988
Cell types associated with angiotensinogen mRNA in rat brain were identified in individual brain sections by in situ hybridization with tritiated RNA probes or with a sulfur-35—labeled oligonucleotide combined with immunocytochemical detection of either glial fibrillary acidic protein (GFAP) for astrocytes or microtubule-associated protein (MAP-2) for ...
R L, Stornetta, C L, Hawelu-Johnson, P G, Guyenet, K R, Lynch   +3 more
openaire   +2 more sources