Results 161 to 170 of about 18,359 (214)

Angiotensinogen

Comprehensive Physiology, 1999
Abstract The sections in this article are: Primary Structure Kinetics of the Renin‐Angiotensinogen Reaction Regulation Hormonal Regulation
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Isolation of human angiotensinogen

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1976
Abstract A four step procedure has been devised for the isolation of human angiotensinogen. Antisera to human angiotensinogen has been prepared. It appears to be an immunochemically homogenous protein. Some heterogeneity can be noted on polycrylamide electrophoresis. The renin-releasable angiotensin I content is only 16% of the theoretical value. The
D A, Tewksbury, M R, Premeau, M L, Dumas
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Biochemistry and Regulation of Angiotensinogen

Clinical and Experimental Hypertension. Part A: Theory and Practice, 1983
Angiotensin II and angiotensin III, the active peptides of the renin-angiotensin system, are produced by a cascade of enzymatic reactions, whose initial step is the reaction between renin and its substrate, angiotensinogen. In plasma, the concentration of angiotensinogen is a limiting factor: the Km of the enzymatic reaction is between 1 and 2 microM ...
J, Ménard, J, Bouhnik, E, Clauser, J P, Richoux, P, Corvol   +4 more
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Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease

American Heart Journal, 1999
Genes encoding components of the renin-angiotensin system have been associated with elevated blood pressure (BP) and an increased risk of coronary artery disease. To explore the role of the angiotensinogen (AGT) gene in coronary atherosclerosis and thrombosis, we studied the effect of the AGT M235T gene variant on plasma AGT levels and BP in patients ...
Winkelmann, Bernhard R., Russ, Andreas P., Nauck, Markus S., Klein, Bärbel, Böhm, Bernhard Otto, Maier, Volker, Zotz, Rainer Bernd, Matheis, Georg, Wolf, Andreas, Wieland, Heinrich, Groß, Werner, Galton, David J., März, Winfried   +12 more
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Structure of Human Angiotensinogen Gene

DNA, 1989
A cDNA clone encoding human angiotensinogen was isolated from a cDNA library prepared from human liver mRNA and used to isolate the angiotensinogen gene. The complete exon sequence of this gene together with extensive intron and flanking sequences are reported. The human angiotensinogen gene contains five exons interrupted by four intervening sequences.
Gaillard, Isabelle, Clauser, E., Corvol, P.   +2 more
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Inhibition of angiogenesis: A new function for angiotensinogen and des(angiotensin I)angiotensinogen

Current Hypertension Reports, 2003
Angiotensinogen (AGT) can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. des(Ang I)AGT, which accounts for more than 97% of the molecule, apparently has no function.
Pierre, Corvol, Noel, Lamandé, Amauri, Cruz, Jerome, Celerier, Jean-Marie, Gasc   +4 more
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Hypertension, Serum Angiotensinogen, and Molecular Variants of the Angiotensinogen Gene Among Nigerians

Circulation, 1997
Background We evaluated the association among the M235T and T174M variants of the angiotensinogen (AGT) gene, plasma AGT, and hypertension status in a sample of Nigerians. Methods and Results Participants were selected from the extremes of the blood pressure distribution obtained ...
C, Rotimi, R, Cooper, O, Ogunbiyi, L, Morrison, M, Ladipo, D, Tewksbury, R, Ward   +6 more
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Angiotensinogen variants and human hypertension

Current Hypertension Reports, 1999
The research on molecular genetics of human hypertension aims to identify the loci involved in the regulation of blood pressure, detect gene variants within the identified loci, associate them with intermediate phenotypes, and ultimately estimate their quantitative effects on blood pressure level and their interaction with main environmental factors ...
X, Jeunemaitre, A P, Gimenez-Roqueplo, J, Célérier, P, Corvol   +3 more
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Angiotensinogen in chronic liver disease

Scandinavian Journal of Clinical and Laboratory Investigation, 1992
The renin substrate angiotensinogen (AGT) belongs to a supergene family of proteins that also includes alpha 1-antitrypsin (AAT) and alpha 1-antichymotrypsin (ACT), acute-phase reactants with known serine proteinase inhibitory (serpin) function. AGT lacks a known inhibitory function but is an acute-phase reactant.
K, Sjöberg, R, Alm, S, Eriksson
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Rescue of Angiotensinogen-Knockout Mice

Biochemical and Biophysical Research Communications, 1998
Angiotensinogen, the precursor of angiotensins I and II, is a critical component of the renin-angiotensin system that plays an important role in regulating blood pressure and electrolyte homeostasis. Genetically altered mice lacking angiotensinogen (Agt-KO) showed an expected phenotype, such as marked hypotension, but unexpected ones including abnormal
J, Ishida, F, Sugiyama, K, Tanimoto, K, Taniguchi, M, Syouji, E, Takimoto, H, Horiguchi, K, Murakami, K i, Yagami, A, Fukamizu   +9 more
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