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Short-Lived Active Prorenin: Precursor of So-Called Native Prorenin. [PDF]
HypertensionThe enzymatic activity of the aspartic protease, renin, is critical for its function in blood pressure regulation and sodium homeostasis. Incubation of so-called native prorenin at low pH leads to its activation. After binding to transition-state mimicking renin inhibitors at neutral pH, prorenin attains the active conformation, as indicated by ...
Schalekamp MADH, Deinum J, Danser AHJ.
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Journal of Molecular Medicine, 2008 For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise.
Danser, Jan +3 more
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Renin/prorenin receptors [PDF]
Kidney International, 2006 The existence of a tissue renin-angiotensin (RAS) system independent of the circulating RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in order to explain their tissue uptake. Two receptors that bind with similar affinity mature renin and prorenin were identified, the mannose-6-phosphate receptor (M6P-R) and a ...
Nguyen, G.
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The prorenin receptor in the cardiovascular system and beyond [PDF]
American Journal of Physiology - Heart and Circulatory Physiology, 2018 Since the prorenin receptor (PRR) was first reported, its physiological role in many cellular processes has been under intense scrutiny. The PRR is currently recognized as a multifunctional receptor with major roles as an accessory protein of the vacuolar-type H+-ATPase and as an intermediary in the Wnt signaling pathway.
Minolfa Prieto, Alexis A Gonzalez
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Journal of the American Society of Nephrology, 2011 The discovery of the prorenin receptor, now nearly a decade ago, altered our view of the renin-angiotensin system (RAS).[1][1],[2][2] Binding of prorenin, the inactive precursor of renin, to the prorenin receptor results in full catalytic activity of prorenin through a nonproteolytic mechanism ...
Meima, Marcel, Danser, Jan
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Hypertension, 1991 Human prorenin is the enzymatically inactive biosynthetic precursor of renin. Recent interest has focused on the posttranslational sorting and processing of prorenin to renin since markedly increased levels of circulating prorenin have been associated with both physiological and pathological changes.
W A, Hsueh, J D, Baxter
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Hypertension, 2006 Prorenin, the precursor of renin, exists in circulating blood at concentrations that are ≈5 to 10× higher than those of renin. For many years, prorenin was considered to be an inactive form of renin with no physiological role. Then, in the mid-80s of the last century, Luetscher et al reported that the levels of circulating prorenin (but not renin) are ...
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Prorenin and Its Ancient Receptor [PDF]
Hypertension, 2006 Prorenin, the precursor of renin, has for a long time been considered to be functionally inert, despite high circulating concentrations. Plasma levels of prorenin usually exceed renin levels and are even further increased under pathological conditions, such as in diabetes.
Céline, Burcklé, Michael, Bader
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Tissue activity of circulating prorenin [PDF]
American Journal of Hypertension, 2002 Both renin and its biosynthetic precursor, prorenin, are secreted into the circulation of mammals. Although the circulating levels of prorenin can exceed those of renin by as much as 100-fold in certain conditions, there is no evidence that prorenin contributes to the synthesis of circulating angiotensin peptide synthesis or increased blood pressure ...
Gary, Prescott +2 more
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Prorenin, Renin, and Their Receptor [PDF]
Hypertension, 2010 In addition to its well-known role in regulating blood pressure and fluid balance, the renin-angiotensin-aldosterone system (RAAS) has continued to fascinate both researchers and clinicians because of the several additional functions that it has been proposed to carry out.
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