Results 1 to 10 of about 28,097 (222)

Impact of AGT rs5050(T>G) variants on associations between estradiol and angiotensinogen levels: Multi-Ethnic Study of Atherosclerosis (MESA). [PDF]

PLoS ONE
AimsAngiotensinogen plays an essential role in maintaining circulatory homeostasis. AGT rs5050(T > G) has been identified as a regulator of the transcription of AGT mRNA, with differential expression between sexes. We sought to determine if rs5050(T > G),
Karita C F Lidani, Patrick J Trainor, Shubham Tomar, Erin D Michos, Erin S Morgan, Jerome I Rotter, Xiuqing Guo, Sotirios Tsimikas, Andrew P DeFilippis   +8 more
doaj   +2 more sources

Circulating Levels of Angiotensinogen, Sex Hormones, and Hormone Therapy—The Multi‐Ethnic Study of Atherosclerosis (MESA) [PDF]

The Journal of Clinical Hypertension
Angiotensinogen, the unique precursor of all angiotensin hormones of the renin‐angiotensin‐aldosterone system (RAAS), is now a potential target in a novel pharmacological approach to hypertension.
Karita C. F. Lidani, Patrick J. Trainor, Robert Buscaglia, Kristoff Foster, Sophia Jaramillo, Kirolos Michael, Alexander P. Landry, Erin D. Michos, Pamela Ouyang, Erin S. Morgan, Sotirios Tsimikas, Andrew P. DeFilippis   +11 more
doaj   +2 more sources

Differential serum dynamics of apelin, elabela, and angiotensinogen in CKD and haemodialysis: insights into peptide modulation across the dialysis procedure [PDF]

Renal Failure
Background Emerging evidence suggests that apelinergic peptides and components of the renin–angiotensin system (RAS) are key regulators of cardiovascular homeostasis and fluid balance, both disrupted in chronic kidney disease (CKD).
Natalia Maria Serwin, Elżbieta Cecerska-Heryć, Bartłomiej Grygorcewicz, Mateusz Cejko, Adrianna Jerzyk, Kacper Ćwikła, Emilia Spajzer, Aleksandra Manelska, Paulina Woźniak, Aleksandra Gomółka, Aleksandra Cader-Ptak, Katarzyna Bąk, Marcin Lisak, Martyna Opara-Bajerowicz, Bartosz Wojciuk, Mariusz Suwała, Karol Serwin, Magda Wiśniewska, Barbara Dołęgowska   +18 more
doaj   +2 more sources

The Association of Angiotensin Converting Enzyme and Angiotensinogen Gene Polymorphism With Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis [PDF]

Reviews in Cardiovascular Medicine
Background: Limited evidence exists for an association between dilated cardiomyopathy (DCM) and the angiotensin-converting enzyme (ACE) gene with an insertion/deletion (I/D) angiotensinogen (AGT) M235T gene polymorphism.
Songbai Du, Ningting Jiang, Yilin He, Zhiming Li, Chang Liu, Rong Luo   +5 more
doaj   +2 more sources

The Molecular Pathology of Pre-Eclamptic Hypertension [PDF]

Current Issues in Molecular Biology
The central role of angiotensinogen in the control of blood pressure is revealed by a series of crystallographic structures, including complexes with renin.
Robin W. Carrell, Randy J. Read, Aiwu Zhou   +2 more
doaj   +2 more sources

Deep learning model and omics screening highlight angiotensinogen as a 5-methylcytosine (m5C) regulated mediator of tumor-microenvironment communication in liver cancer [PDF]

Frontiers in Immunology
IntroductionThe tumor microenvironment (TME) is critical for liver cancer progression and therapy response. As a key RNA modification, 5-methylcytosine (m5C) methylation is implicated in this process, yet the molecular mechanisms by which m5C ...
Huai Pang, Huai Pang, Huai Pang, Linshu Wang, Yang Li, Yuan Zhou, Yuan Zhou   +6 more
doaj   +2 more sources

Angiotensinogen and C3 compete for renin-induced complement activation [PDF]

Frontiers in Immunology
Renin from plasma, kidney, and recombinant sources was previously demonstrated to cleave C3 to C3a and C3b. C3a was generated at a similar rate to that by C3 convertase, and C3 cleavage was inhibited by the renin inhibitor aliskiren.
Ann-Charlotte Kristoffersson, Albin Sköld, Charlotte Welinder, Markus Wendler, Gabriella Kalliokoski, Zivile Bekassy, Diana Karpman   +6 more
doaj   +2 more sources

Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure.
Estrellita Uijl, Dien Ye, Liwei Ren, Katrina M. Mirabito Colafella, Richard van Veghel, Ingrid M. Garrelds, Hong S. Lu, Alan Daugherty, Ewout J. Hoorn, Paul Nioi, Don Foster, A. H. Jan Danser   +11 more
doaj   +1 more source

Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study. [PDF]

PLoS ONE, 2015
Angiotensinogen exists in two distinct redox forms in plasma, the oxidized sulfhydryl-bridge form and the reduced, unbridged, free thiol form. The oxidized form of angiotensinogen compared to the free thiol form preferentially interacts with renin ...
Soheila Rahgozar, Tayebeh Amirian, Miao Qi, Zahra Shahshahan, Mansureh Entezar-E-Ghaem, Hatav Ghasemi Tehrani, Mehran Miroliaei, Steven A Krilis, Bill Giannakopoulos   +8 more
doaj   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source