Results 1 to 10 of about 18,359 (214)

Impact of AGT rs5050(T>G) variants on associations between estradiol and angiotensinogen levels: Multi-Ethnic Study of Atherosclerosis (MESA). [PDF]

PLoS ONE
AimsAngiotensinogen plays an essential role in maintaining circulatory homeostasis. AGT rs5050(T > G) has been identified as a regulator of the transcription of AGT mRNA, with differential expression between sexes. We sought to determine if rs5050(T > G),
Karita C F Lidani, Patrick J Trainor, Shubham Tomar, Erin D Michos, Erin S Morgan, Jerome I Rotter, Xiuqing Guo, Sotirios Tsimikas, Andrew P DeFilippis   +8 more
doaj   +2 more sources

Blood Levels of Angiotensinogen and Risk of Ischemic Stroke: The Multi‐Ethnic Study of Atherosclerosis [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We investigated whether circulating angiotensinogen levels are associated with the risk of ischemic stroke and examined sex‐specific differences.
Soroush Masrouri, Patrick J. Trainor, Parag Anilkumar Chevli, João A.C. Lima, Sotirios Tsimikas, Andrew P. DeFilippis, Michael D. Shapiro   +6 more
doaj   +2 more sources

Characterization of elevated levels of endometrial renin–angiotensin system components suggest a role in endometrial repair [PDF]

Frontiers in Endocrinology
IntroductionEach month, the endometrium is shed, regenerated, and transformed in response to changing hormone levels. These processes occur in a tightly regulated manner, and irregularities are linked with reproductive health conditions such as ...
Tess L. Symington, Tess L. Symington, Joshua J. Fisher, Joshua J. Fisher, Wei Zhou, Wei Zhou, Evdokia Dimitriadis, Evdokia Dimitriadis, Eugenie R. Lumbers, Eugenie R. Lumbers, Paul Tooney, Paul Tooney, Kirsty G. Pringle, Kirsty G. Pringle   +13 more
doaj   +2 more sources

Zilebesiran, a Small Interfering RNA Therapeutic Targeting Angiotensinogen: Mechanism, Clinical Evidence, Safety, and Implementation Considerations [PDF]

Life
Hypertension remains a major global health burden, and control rates remain suboptimal because of poor medication adherence and limitations of existing therapies, including escape within the renin–angiotensin–aldosterone system.
Jawaria, Areeba Noor, Yusra Zarlashat, Muhammad Ebad Asif Khan, Enrique Mandado Loureiro, Edit Dósa   +5 more
doaj   +2 more sources

Differential serum dynamics of apelin, elabela, and angiotensinogen in CKD and haemodialysis: insights into peptide modulation across the dialysis procedure [PDF]

Renal Failure
Background Emerging evidence suggests that apelinergic peptides and components of the renin–angiotensin system (RAS) are key regulators of cardiovascular homeostasis and fluid balance, both disrupted in chronic kidney disease (CKD).
Natalia Maria Serwin, Elżbieta Cecerska-Heryć, Bartłomiej Grygorcewicz, Mateusz Cejko, Adrianna Jerzyk, Kacper Ćwikła, Emilia Spajzer, Aleksandra Manelska, Paulina Woźniak, Aleksandra Gomółka, Aleksandra Cader-Ptak, Katarzyna Bąk, Marcin Lisak, Martyna Opara-Bajerowicz, Bartosz Wojciuk, Mariusz Suwała, Karol Serwin, Magda Wiśniewska, Barbara Dołęgowska   +18 more
doaj   +2 more sources

Circulating Levels of Angiotensinogen, Sex Hormones, and Hormone Therapy—The Multi‐Ethnic Study of Atherosclerosis (MESA) [PDF]

The Journal of Clinical Hypertension
Angiotensinogen, the unique precursor of all angiotensin hormones of the renin‐angiotensin‐aldosterone system (RAAS), is now a potential target in a novel pharmacological approach to hypertension.
Karita C. F. Lidani, Patrick J. Trainor, Robert Buscaglia, Kristoff Foster, Sophia Jaramillo, Kirolos Michael, Alexander P. Landry, Erin D. Michos, Pamela Ouyang, Erin S. Morgan, Sotirios Tsimikas, Andrew P. DeFilippis   +11 more
doaj   +2 more sources

Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure.
Estrellita Uijl, Dien Ye, Liwei Ren, Katrina M. Mirabito Colafella, Richard van Veghel, Ingrid M. Garrelds, Hong S. Lu, Alan Daugherty, Ewout J. Hoorn, Paul Nioi, Don Foster, A. H. Jan Danser   +11 more
doaj   +1 more source

Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study. [PDF]

PLoS ONE, 2015
Angiotensinogen exists in two distinct redox forms in plasma, the oxidized sulfhydryl-bridge form and the reduced, unbridged, free thiol form. The oxidized form of angiotensinogen compared to the free thiol form preferentially interacts with renin ...
Soheila Rahgozar, Tayebeh Amirian, Miao Qi, Zahra Shahshahan, Mansureh Entezar-E-Ghaem, Hatav Ghasemi Tehrani, Mehran Miroliaei, Steven A Krilis, Bill Giannakopoulos   +8 more
doaj   +1 more source

Urinary Angiotensinogen-Melatonin Ratio in Gestational Diabetes and Preeclampsia

Frontiers in Molecular Biosciences, 2022
Background: A large research portfolio indicates that an activated renal renin-angiotensin system or a deficit on melatonin is associated with several cardiovascular pathologies.
Gabriela Ribeiro Valias, Patricia Rodrigues Lourenço Gomes, Fernanda G. Amaral, Saif Alnuaimi, Daniela Monteiro, Siobhán O'Sullivan, Renato Zangaro, José Cipolla-Neto, Juan Acuna, Ovidiu Constantin Baltatu, Ovidiu Constantin Baltatu, Luciana Aparecida Campos, Luciana Aparecida Campos   +12 more
doaj   +1 more source

Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis

Cells, 2021
We has identified a founder homozygous E3_E4 del: 2870 bp deletion + 9 bp insertion in AGT gene encoding angiotensinogen responsible for autosomal recessive renal tubular dysgenesis (ARRTD) with nearly-fatal outcome.
Min-Hua Tseng, Shih-Ming Huang, Martin Konrad, Jing-Long Huang, Steven W. Shaw, Ya-Chung Tian, Ho-Yen Chueh, Wen-Lang Fan, Tai-Wei Wu, Jhao-Jhuang Ding, Ming-Chou Chiang, Shih-Hua Lin   +11 more
doaj   +1 more source