Results 1 to 10 of about 1,765 (116)

The prorenin receptor in the cardiovascular system and beyond [PDF]

American Journal of Physiology - Heart and Circulatory Physiology, 2018
Since the prorenin receptor (PRR) was first reported, its physiological role in many cellular processes has been under intense scrutiny. The PRR is currently recognized as a multifunctional receptor with major roles as an accessory protein of the vacuolar-type H+-ATPase and as an intermediary in the Wnt signaling pathway.
Alexis A Gonzalez, Minolfa C Prieto
exaly   +4 more sources

Prorenin receptor is critical for nephron progenitors [PDF]

Developmental Biology, 2016
Deficient nephrogenesis is the major factor contributing to renal hypoplasia defined as abnormally small kidneys. Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells of the cap mesenchyme (CM) and the ureteric bud (UB).
Renfang Song, Graeme Preston, Laura Kidd   +2 more
exaly   +4 more sources

Role of the prorenin receptor in endometrial cancer cell growth. [PDF]

Oncotarget, 2022
Endometrial cancer is the most diagnosed gynecological malignancy. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer continues to rise. Emerging evidence suggests a putative role of the (pro)renin receptor ((P)RR), in the ontogenesis of endometrial cancer.
Martin JH, Mohammed R, Delforce SJ, Skerrett-Byrne DA, de Meaultsart CC, Almazi JG, Stephens AN, Verrills NM, Dimitriadis E, Wang Y, Lumbers ER, Pringle KG.   +11 more
europepmc   +4 more sources

Prorenin receptor mediates inflammation in renal ischemia. [PDF]

Clin Exp Pharmacol Physiol, 2018
SummaryWe hypothesized that PRR contributes to renal inflammation in the 2‐kidney, 1‐clip (2K1C) renal ischaemia model. Male Sprague‐Dawley rats were fed normal sodium diet. Blood pressure (BP) was obtained on days 0 and 28 after left renal artery clipping that reduced renal blood flow by 40%.
Quadri SS, Culver S, Siragy HM.
europepmc   +4 more sources

Stromal prorenin receptor is critical for normal kidney development. [PDF]

Am J Physiol Regul Integr Comp Physiol, 2019
Formation of the metanephric kidney requires coordinated interaction among the stroma, ureteric bud, and cap mesenchyme. The transcription factor Foxd1, a specific marker of renal stromal cells, is critical for normal kidney development. The prorenin receptor (PRR), a receptor for renin and prorenin, is also an accessory subunit of the vacuolar proton ...
Yosypiv IV, Sequeira-Lopez MLS, Song R, De Goes Martini A.   +3 more
europepmc   +3 more sources

Prorenin Receptor, a Necessary Component in Urine Concentration Mechanism. [PDF]

J Am Soc Nephrol, 2016
In this issue of the Journal of the American Society of Nephrology ( JASN ), Wang et al. [1][1] unravel an intriguing new signaling cascade that involves the prorenin receptor (PRR) in the kidney collecting ducts (CDs) as a necessary component of the physiologic ability of the kidneys to ...
Jensen BL.
europepmc   +4 more sources

Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet-Dependent Thrombin Formation and Release of Profibrotic TGF-β. [PDF]

FASEB J
Platelets interact with extracellular vesicles shed by hepatic stellate cells to activate both cell types. Extracellular vesicles shed by activated hepatic stellate cells contain inactive prorenin. HSC‐EV interact with quiescent platelets to non‐proteolytically activate ligated prorenin.
Chen R, Huang E, Wu X, McMullen MR, Wang X, Nagy LE, Jin G, Cameron SJ, McIntyre TM.   +8 more
europepmc   +2 more sources

The prorenin receptor and its soluble form contribute to lipid homeostasis.

Am J Physiol Endocrinol Metab, 2021
Hepatic PRR and its soluble form, sPRR, contribute to triglyceride and cholesterol homeostasis and hepatic inflammation. Deletion of hepatic PRR decreased triglyceride levels through a PRR-PPARγ-dependent mechanism but increased hepatic cholesterol synthesis through sPRR-medicated upregulation of SREBP-2.
Gatineau E, Arthur G, Poupeau A, Nichols K, Spear BT, Shelman NR, Graf GA, Temel RE, Yiannikouris FB.   +8 more
europepmc   +4 more sources

Prorenin receptor is essential for podocyte autophagy and survival. [PDF]

J Am Soc Nephrol, 2011
The prorenin receptor (PRR) is highly expressed in podocytes, but its role in the maintenance of podocyte function is unknown. Here we generated podocyte-specific PRR-knockout mice and found that these animals died between 2 to 3 wk after birth. Within 14 d, PRR-knockout mice developed nephrotic syndrome, albuminuria with podocyte foot-process fusion ...
Riediger F, Quack I, Qadri F, Hartleben B, Park JK, Potthoff SA, Sohn D, Sihn G, Rousselle A, Fokuhl V, Maschke U, Purfürst B, Schneider W, Rump LC, Luft FC, Dechend R, Bader M, Huber TB, Nguyen G, Muller DN.   +19 more
europepmc   +5 more sources

Differential Roles of Angiotensin A and Alamandine in Parkinson's Disease: A Therapeutic Perspective on Nonclassical RAS Pathways. [PDF]

Brain Behav
The role of the Classical and Non‐Classical RAS pathway in Parkinson's disease: Pathogenesis and Therapeutic strategies. PD, Parkinson's disease; DNs, Dopaminergic neurons; SN, Substantia Nigra; α‐syn, alpha‐synuclein; RAS, renin‐angiotensin system; Ang II, Angiotensin II; AT1R, Angiotensin II type 1 Receptor; ACE2, angiotensin‐converting enzyme 2; Ang
Alshehri GH, Al-Kuraishy HM, Albuhadily AK, Al-Gareeb AI, Aboutaleb AS, Alexiou A, Papadakis M, Batiha GE.   +7 more
europepmc   +2 more sources