The prorenin receptor in the cardiovascular system and beyond [PDF]
American Journal of Physiology - Heart and Circulatory Physiology, 2018 Since the prorenin receptor (PRR) was first reported, its physiological role in many cellular processes has been under intense scrutiny. The PRR is currently recognized as a multifunctional receptor with major roles as an accessory protein of the vacuolar-type H+-ATPase and as an intermediary in the Wnt signaling pathway.
Minolfa Prieto, Alexis A Gonzalez
exaly +6 more sources
Stromal prorenin receptor is critical for normal kidney development [PDF]
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2019 Formation of the metanephric kidney requires coordinated interaction among the stroma, ureteric bud, and cap mesenchyme. The transcription factor Foxd1, a specific marker of renal stromal cells, is critical for normal kidney development. The prorenin receptor (PRR), a receptor for renin and prorenin, is also an accessory subunit of the vacuolar proton ...
Maria Luisa S Sequeira-Lopez +2 more
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High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct [PDF]
Scientific Reports, 2021 Growing evidence indicates that prorenin receptor (PRR) is upregulated in collecting duct (CD) of diabetic kidney. Prorenin is secreted by the principal CD cells, and is the natural ligand of the PRR. PRR activation stimulates fibrotic factors, including
Venkateswara R. Gogulamudi +8 more
doaj +3 more sources
Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension [PDF]
Function, 2023 Non-enzymatic activation of renin via its interaction with prorenin receptor (PRR) has been proposed as a key mechanism of local renin–angiotensin system (RAS) activation.
Natalia M Mathieu +16 more
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Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct [PDF]
Current Hypertension Reviews, 2022 The production of renin by the principal cells of the collecting duct has widened our understanding of the regulation of intrarenal angiotensin II (Ang II) generation and blood pressure. In the collecting duct, Ang II increases synthesis and secretion of
Lara Ls, Alexis A Gonzalez
exaly +3 more sources
Role of the prorenin receptor in endometrial cancer cell growth. [PDF]
Oncotarget, 2022 Endometrial cancer is the most diagnosed gynecological malignancy. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer continues to rise. Emerging evidence suggests a putative role of the (pro)renin receptor ((P)RR), in the ontogenesis of endometrial cancer.
Martin JH +11 more
europepmc +5 more sources
Sex differences in soluble prorenin receptor in patients with type 2 diabetes [PDF]
Biology of Sex Differences, 2021 Background The soluble prorenin receptor (sPRR), a member of the renin-angiotensin system (RAS), is elevated in plasma of patients with preeclampsia, hypertension, chronic kidney disease (CKD), and type 2 diabetes.
Bruna Visniauskas +14 more
doaj +3 more sources
Soluble Prorenin Receptor Increases Blood Pressure in High Fat–Fed Male Mice [PDF]
Hypertension, 2019 Obesity-related hypertension is a major public health concern. We recently demonstrated that plasma levels of the soluble form of the prorenin receptor (sPRR) were elevated in obesity-associated hypertension.
Eva Gatineau +2 more
exaly +3 more sources
The prorenin receptor and its soluble form contribute to lipid homeostasis.
Am J Physiol Endocrinol Metab, 2021 Hepatic PRR and its soluble form, sPRR, contribute to triglyceride and cholesterol homeostasis and hepatic inflammation. Deletion of hepatic PRR decreased triglyceride levels through a PRR-PPARγ-dependent mechanism but increased hepatic cholesterol synthesis through sPRR-medicated upregulation of SREBP-2.
Gatineau E +8 more
europepmc +5 more sources
Prorenin receptor mediates inflammation in renal ischemia. [PDF]
Clin Exp Pharmacol Physiol, 2018 SummaryWe hypothesized that PRR contributes to renal inflammation in the 2‐kidney, 1‐clip (2K1C) renal ischaemia model. Male Sprague‐Dawley rats were fed normal sodium diet. Blood pressure (BP) was obtained on days 0 and 28 after left renal artery clipping that reduced renal blood flow by 40%.
Quadri SS, Culver S, Siragy HM.
europepmc +5 more sources