Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension. [PDF]
Physiol Rep, 2018 Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells (NPCs) of the cap mesenchyme (CM) and the ureteric bud (UB).
Song R, Kidd L, Janssen A, Yosypiv IV.
europepmc +2 more sources
Effect of heme oxygenase 1 and renin/prorenin receptor on oxidized low-density lipoprotein-induced human umbilical vein endothelial cells. [PDF]
Exp Ther Med, 2019 The incidence of depression has previously been correlated to hypertension. The aim of the present study was to explore the mechanisms of depression and hypertension by examining the expression and interaction of renin/prorenin receptor (PRR) and heme ...
Gong X +5 more
europepmc +2 more sources
Nephron prorenin receptor deficiency alters renal medullary endothelin-1 and endothelin receptor expression. [PDF]
Physiol Res, 2018 Summary The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption.
Ramkumar N +3 more
europepmc +2 more sources
Prorenin Receptor, a Necessary Component in Urine Concentration Mechanism. [PDF]
J Am Soc Nephrol, 2016 In this issue of the Journal of the American Society of Nephrology ( JASN ), Wang et al. [1][1] unravel an intriguing new signaling cascade that involves the prorenin receptor (PRR) in the kidney collecting ducts (CDs) as a necessary component of the physiologic ability of the kidneys to ...
Jensen BL.
europepmc +4 more sources
Prorenin receptor (PRR)-mediated NADPH oxidase (Nox) signaling regulates VEGF synthesis under hyperglycemic condition in ARPE-19 cells. [PDF]
J Recept Signal Transduct Res, 2017 The stimulation of angiotensin II (Ang II), the effector peptide of renin–angiotensin system, has been reported to increase the expression of vascular endothelial growth factor (VEGF) through the activation of the Ang II type 1 receptor (AT1R).
Haque R +10 more
europepmc +2 more sources
Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis. [PDF]
Oncotarget, 2016 Recent studies have implicated the prorenin receptor (PRR) is associated with pancreatic tumorigenesis. We therefore investigated the role of PRR in pancreatic tumorigenesis and assessed whether PRR can serve as a target for imaging diagnosis at early ...
Arundhathi A +10 more
europepmc +2 more sources
Prorenin receptor is essential for podocyte autophagy and survival. [PDF]
J Am Soc Nephrol, 2011 The prorenin receptor (PRR) is highly expressed in podocytes, but its role in the maintenance of podocyte function is unknown. Here we generated podocyte-specific PRR-knockout mice and found that these animals died between 2 to 3 wk after birth. Within 14 d, PRR-knockout mice developed nephrotic syndrome, albuminuria with podocyte foot-process fusion ...
Riediger F +19 more
europepmc +5 more sources
Trafficking of the Prorenin Receptor in Endothelial Cells
The FASEB Journal, 2020 Diabetic patients are at higher risk for hypertension and cardiovascular mortality than their normotensive, nondiabetic counterparts. Diabetic patients also have increased circulating prorenin which can bind to its receptor (PRR) to cause activation of the renin‐angiotensin system and ...
Nicholas R. Harris +6 more
openaire +2 more sources
Direct pro-inflammatory effects of prorenin on microglia. [PDF]
PLoS ONE, 2014 Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of the ...
Peng Shi +8 more
doaj +2 more sources
Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. [PDF]
PLoS ONE, 2013 The role of the prorenin receptor (PRR) in the regulation of ureteric bud (UB) branching morphogenesis is unknown. Here, we investigated whether PRR acts specifically in the UB to regulate UB branching, kidney development and function.
Renfang Song +3 more
doaj +2 more sources