Results 31 to 40 of about 1,765 (116)

Preascitic Sodium Retention in Cirrhosis: A Role for Disregulated Proteolysis by Proprotein Convertases?

Liver International Communications, Volume 6, Issue 2, June 2025.
ABSTRACT Loss of effective arterial blood volume, secondary hyperaldosteronism, adrenergic activation and nonosmotic hypersecretion of vasopressin induce sodium and water retention in cirrhotic patients with ascites. The mechanisms of sodium retention that precede ascites formation remain elusive.
Giovanni Sansoè, Manuela Aragno, Florence Wong   +2 more
wiley   +1 more source

(Pro)renin, Erythropoietin, Vitamin D and Urodilatin Release From Human Donor Kidneys During Normothermic Machine Perfusion: Predictors of Early Post‐Transplant Outcome?

Clinical Transplantation, Volume 39, Issue 5, May 2025.
ABSTRACT Background Human donor kidneys release (pro)renin, erythropoietin (EPO), active vitamin D, and urodilatin during normothermic machine perfusion (NMP). However, whether the endocrine function of donor kidneys is associated with post‐transplant kidney function is unclear.
Hui Lin, Karim Bousnina, Julia S. Slagter, Yitian Fang, Iacopo Cristoferi, Ingrid M. Garrelds, A. H. Jan Danser, Marlies E. J. Reinders, Robert C. Minnee, Martin J. Hoogduijn   +9 more
wiley   +1 more source

Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials

Health Science Reports, Volume 8, Issue 3, March 2025.
ABSTRACT Background and Aims Hypertension exacerbates cardiovascular risks in patients with type 1 diabetes mellitus (T1DM), necessitating effective blood pressure (BP) management. Vitamin D deficiency is common in T1DM patients and is associated with an increased risk of cardiovascular diseases.
Rasoul Ebrahimi, Mohammad Mahdi Masouri, Amir Abbas Salehi Amniyeh Khozani, Sana Mohammad Soltani, Seyed Aria Nejadghaderi   +4 more
wiley   +1 more source

Wnt signalosomes: What we know that we do not know

BioEssays, Volume 47, Issue 2, February 2025.
Wnt signaling occurs through a “signalosome” receptor complex, driven by oligomerization of the adaptor, Disheveled (Dvl). Both endocytosis and condensate formation have been proposed to mediate signalosome formation. Under pathological conditions, signalosomes may form in a Wnt ligand‐independent manner.
Heather Hartmann, Ghalia Saad Siddiqui, Jamal Bryant, David J. Robbins, Vivian L. Weiss, Yashi Ahmed, Ethan Lee   +6 more
wiley   +1 more source

Biochemical properties of renin and prorenin binding to the (pro)renin receptor [PDF]

Hypertension Research, 2009
The discovery of (pro)renin receptor, (P)RR, has made the renin-angiotensin system (RAS) more multifaceted. Interaction of renin and prorenin with this receptor has set a new perspective about the physiological functions, activation mechanism and pathophysiological roles of renin/prorenin.
A H M Nurun, Nabi, Fumiaki, Suzuki
openaire   +2 more sources

Phosphoproteomics for studying signaling pathways evoked by hormones of the renin‐angiotensin system: A source of untapped potential

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract The Renin‐Angiotensin System (RAS) is a complex neuroendocrine system consisting of a single precursor protein, angiotensinogen (AGT), which is processed into various peptide hormones, including the angiotensins [Ang I, Ang II, Ang III, Ang IV, Ang‐(1–9), Ang‐(1–7), Ang‐(1–5), etc] and Alamandine‐related peptides [Ang A, Alamandine, Ala‐(1–5)],
Igor Maciel Souza‐Silva, Victor Corasolla Carregari, U. Muscha Steckelings, Thiago Verano‐Braga   +3 more
wiley   +1 more source

Critical Review of Prorenin and (Pro)renin Receptor Research [PDF]

Hypertension, 2008
The renin-angiotensin system (RAS) plays an important role in cardiovascular and renal physiology and disease, and the benefits of angiotensin-converting enzyme inhibitor, angiotensin type 1 receptor blocker, and renin inhibitor therapies are mediated in part by their modification of the levels and actions of angiotensin peptides.
openaire   +2 more sources

The Role of Angiotensin‐II Infusion in an Infant With Autosomal Recessive Polycystic Kidney Disease Postbilateral Nephrectomies and Refractory Hypotension in the Neonatal Period

Case Reports in Nephrology, Volume 2025, Issue 1, 2025.
Autosomal recessive polycystic kidney disease (ARPKD) is a form of hereditary cystic disease with a highly variable phenotypic expression that ultimately leads to chronic kidney disease. Severe cases may warrant surgical intervention with unilateral or bilateral nephrectomy to alleviate thoracic and abdominal compression from massive nephromegaly ...
Ana Nevarez Gilbert, Adrianne Rahde Bischoff, Kyle Merrill, Yoshihide Fujigaki   +3 more
wiley   +1 more source

A Benign Renal Tumor With Serious Consequences: A Case Report of Juxtaglomerular Cell Tumor and Chronic Renal Disease in a Teenager

Case Reports in Pediatrics, Volume 2025, Issue 1, 2025.
Juxtaglomerular cell tumor (JGCT), or reninoma, is a rare benign renal neoplasm. It is characterized by severe hypertension and hypokalemia due to excessive renin produced from the juxtaglomerular apparatus on the afferent arteriole of the glomerulus. Herein, we report a case of JGCT in a 15‐year‐old female who presented with severe hypertension.
Rachael Courtney, Erin Dahlinghaus, Abiodun Omoloja, Jeffrey T. Boyd, Michelle Smith, Laura Biederman, Israel Ndengabaganizi, Daniel Keith Robie, Ahmad Al Dughiem, Andrea Scaramuzza   +9 more
wiley   +1 more source

The effect of 30 min of supine rest on plasma renin concentrations in paediatric patients

Acta Paediatrica, Volume 113, Issue 11, Page 2473-2478, November 2024.
Abstract Aim The aim of this study is to interpret plasma renin concentrations (PRCs) correctly in a clinical setting, it is essential to understand to what extent physical activity influences the concentration. Reference values for different postural positions exist for adults, but data for children are sparse.
D. F. Al‐Zoubaidi, T. H. Johannsen, N. R. Jørgensen, K. M. Main   +3 more
wiley   +1 more source