Results 21 to 30 of about 1,765 (116)
Renin/prorenin receptors [PDF]
Kidney International, 2006 The existence of a tissue renin-angiotensin (RAS) system independent of the circulating RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in order to explain their tissue uptake. Two receptors that bind with similar affinity mature renin and prorenin were identified, the mannose-6-phosphate receptor (M6P-R) and a ...
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Nephron-specific deletion of the prorenin receptor causes a urine concentration defect
American Journal of Physiology - Renal Physiology, 2015 Nirupama Ramkumar +2 more
exaly +2 more sources
Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport
American Journal of Physiology - Renal Physiology, 2016 Nirupama Ramkumar +2 more
exaly +2 more sources
Prorenin, Renin, and Their Receptor [PDF]
Hypertension, 2010 In addition to its well-known role in regulating blood pressure and fluid balance, the renin-angiotensin-aldosterone system (RAAS) has continued to fascinate both researchers and clinicians because of the several additional functions that it has been proposed to carry out.
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Receptor-mediated actions of renin and prorenin [PDF]
Kidney International, 2006 Renin can induce renal disease by generating angiotensin II and, thereby, increasing fibrosis. Huang et al describe a new mechanism of action whereby the renin-angiotensin system can also exert this effect. Direct activation of the renin/prorenin receptor in mesangial cells induced synthesis of TGF-beta and profibrotic proteins.
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Receptor-associated prorenin system in the pathogenesis of retinal diseases [PDF]
Frontiers in Bioscience, 2012 Receptor-associated prorenin system (RAPS) refers to the pathogenic mechanisms whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling through the receptor. Although we found significant involvement of angiotensin II type 1 receptor (AT1-R) in intraocular
Shingo, Satofuka +2 more
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Prorenin and the (Pro)renin Receptor in Ocular Pathology [PDF]
The American Journal of Pathology, 2008 This commentary reports on the protective effects of a (pro)renin receptor inhibitor in an experimental model of age-related macular degeneration.
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Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.Myocardial infarction triggers cardiomyocyte depletion and sympathetic overactivation, culminating in irreversible heart failure. Renal denervation (RD) attenuates sympathetic signalling, modulating catecholamine‒B‐type natriuretic peptide (BNP) homeostasis.
Lan Zhao +7 more
wiley +1 more source
The renal baroreflex: A systematic review and meta‐analysis in healthy and hypertensive animals
Physiological Reports, Volume 13, Issue 17, September 2025.Abstract The renal baroreflex describes the dose‐dependent relation between renal pressure and renin release. Former studies have approximated this relation through animal experiments, but the exact shape of the response curve and its alteration by hypertension remain unclear.
Maaike van Ochten +5 more
wiley +1 more source
Physiological Reports, Volume 13, Issue 17, September 2025.Abstract This study was conducted to examine the ontogeny of and interactions between the thyroid system and local renin‐angiotensin systems (RAS) in the porcine fetus. N = 24 pregnant gilts were split into two groups, receiving either a daily dose of methimazole to induce fetal hypothyroidism, or a daily sham control. Within each group, treatment of n
Alyssa A. Smith, J. Alex Pasternak
wiley +1 more source