Results 21 to 30 of about 3,903,665 (206)
Hypertension, 2020 Megalin is an endocytic receptor contributing to protein reabsorption. Impaired expression or trafficking of megalin increases urinary renin and allowed the detection of prorenin, which normally is absent in urine. Here, we investigated (pro)renin uptake by megalin, using both conditionally immortalized proximal tubule epithelial cells and Brown Norway
Sun, Yuan +6 more
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Renin/prorenin receptors [PDF]
Kidney International, 2006 The existence of a tissue renin-angiotensin (RAS) system independent of the circulating RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in order to explain their tissue uptake. Two receptors that bind with similar affinity mature renin and prorenin were identified, the mannose-6-phosphate receptor (M6P-R) and a ...
Nguyen, G.
openaire +4 more sources
Am J Physiol Renal PhysiolSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans.
Arthur G +7 more
europepmc +2 more sources
Recent Advances in Soluble Prorenin Receptor in Multisystem Diseases [PDF]
Zhongguo quanke yixuePrevious studies on renin-angiotensin-aldosterone system (RAAS) mainly focus on renin, prorenin and prorenin receptor (PRR), which play an important role in cardiovascular, renal and other diseases.
LI Mengye, JIANG Yinong
doaj +3 more sources
Receptor-mediated actions of renin and prorenin [PDF]
Kidney International, 2006 Renin can induce renal disease by generating angiotensin II and, thereby, increasing fibrosis. Huang et al describe a new mechanism of action whereby the renin-angiotensin system can also exert this effect. Direct activation of the renin/prorenin receptor in mesangial cells induced synthesis of TGF-beta and profibrotic proteins.
Oliver, J.A.
openaire +4 more sources
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. [PDF]
Oncotarget, 2019 Phosphatase and tensin homolog (PTEN) tumor suppressor protein loss is common in prostate cancer (PCa). PTEN loss increases PI3K/Akt signaling, which promotes cell growth and survival. To find secreted biomarkers of PTEN loss, a proteomic screen was used
Mohammad AH +16 more
europepmc +2 more sources
Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport
American Journal of Physiology - Renal Physiology, 2016 Atsuhiro Ichihara +2 more
exaly +3 more sources
Characterization of elevated levels of endometrial renin–angiotensin system components suggest a role in endometrial repair [PDF]
Frontiers in EndocrinologyIntroductionEach month, the endometrium is shed, regenerated, and transformed in response to changing hormone levels. These processes occur in a tightly regulated manner, and irregularities are linked with reproductive health conditions such as ...
Tess L. Symington +13 more
doaj +2 more sources
Nephron-specific deletion of the prorenin receptor causes a urine concentration defect
American Journal of Physiology - Renal Physiology, 2015 Helmy Siragy +2 more
exaly +3 more sources
Correction: Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis. [PDF]
Oncotarget, 2019 [This corrects the article DOI: 10.18632/oncotarget.10583.].
Arundhathi A +10 more
europepmc +2 more sources