Results 11 to 20 of about 3,903,665 (206)

Prorenin receptor is critical for nephron progenitors [PDF]

Developmental Biology, 2016
Deficient nephrogenesis is the major factor contributing to renal hypoplasia defined as abnormally small kidneys. Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells of the cap mesenchyme (CM) and the ureteric bud (UB).
Graeme Preston, Laura Kidd, Ihor Yosypiv   +2 more
exaly   +6 more sources

Vacuolar H+‐ATPase and Megalin‐Mediated Prorenin Uptake: Focus on Elements Beyond the (Pro)Renin Receptor [PDF]

Journal of Cellular Physiology, Volume 240, Issue 1, January 2025.
Megalin is a multiple‐ligand receptor that contributes to protein reabsorption in the kidney. Recently, megalin was found to act as a novel endocytic receptor for prorenin. Internalization depended on the (pro)renin receptor.
Na Wang, Xi-Feng Lu, A. H. Jan Danser
semanticscholar   +4 more sources

Prorenin receptor is essential for normal podocyte structure and function. [PDF]

J Am Soc Nephrol, 2011
The prorenin receptor is an accessory subunit of the vacuolar H(+)-ATPase, suggesting that it has fundamental functions beyond activation of the local renin-angiotensin system. Podocytes express the prorenin receptor, but its function in these cells is unknown. Here, podocyte-specific, conditional, prorenin receptor-knockout mice died of kidney failure
Oshima Y, Kinouchi K, Ichihara A, Sakoda M, Kurauchi-Mito A, Bokuda K, Narita T, Kurosawa H, Sun-Wada GH, Wada Y, Yamada T, Takemoto M, Saleem MA, Quaggin SE, Itoh H.   +14 more
europepmc   +5 more sources

The macula densa prorenin receptor is essential in renin release and blood pressure control

American Journal of Physiology - Renal Physiology, 2018
The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS); however, recent work questioned their association.
Arnold Sipos, János Peti-Peterdi, Georgina Gyarmati   +2 more
exaly   +3 more sources

Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion

American Journal of Physiology - Renal Physiology, 2018
The collecting duct is the predominant nephron site of prorenin and prorenin receptor (PRR) expression. We previously demonstrated that the collecting duct PRR regulates epithelial Na+ channel (ENaC) activity and water transport; however, which cell type
Donald Kohan, Deborah Stuart, Elena Mironova   +2 more
exaly   +3 more sources

Cleavage of the V-ATPase associated prorenin receptor is mediated by PACE4 and is essential for growth of prostate cancer cells. [PDF]

PLoS One, 2023
Phosphatase and tensin homolog (PTEN) mutation is common in prostate cancer during progression to metastatic and castration resistant forms. We previously reported that loss of PTEN function in prostate cancer leads to increased expression and secretion ...
Mohammad AH, Couture F, Gamache I, Chen O, El-Assaad W, Abdel-Malak N, Kwiatkowska A, Muller W, Day R, Teodoro JG.   +9 more
europepmc   +2 more sources

High-plasma soluble prorenin receptor is associated with vascular damage in male, but not female, mice fed a high-fat diet.

Am J Physiol Heart Circ Physiol, 2023
Plasma soluble prorenin receptor (sPRR) displays sexual dimorphism and is higher in women with type 2 diabetes mellitus (T2DM). However, the contribution of plasma sPRR to the development of vascular complications in T2DM remains unclear. We investigated
Visniauskas B, Reverte V, Abshire CM, Ogola BO, Rosales CB, Galeas-Pena M, Sure VN, Sakamuri SSVP, Harris NR, Kilanowski-Doroh I, Mcnally AB, Horton AC, Zimmerman M, Katakam PVG, Lindsey SH, Prieto MC.   +15 more
europepmc   +2 more sources

S1P (Site-1 Protease)-Induced Release of the Soluble Prorenin Receptor in Hypertension: Do All Roads Lead to Ang II (Angiotensin II)? [PDF]

Hypertension, 2021
Since the initial discovery of a pressor activity in kidney homogenates to its isolation and identification almost 100 years later, the protease renin constitutes a critical step in the activation of the reninangiotensin system (RAS) cascade leading to ...
Chappell MC.
europepmc   +2 more sources

Deletion of the prorenin receptor in the ureteric bud in mice inhibits Dot1/H3K79 pathway. [PDF]

Pediatr Res
The prorenin receptor (PRR) plays a critical role in ureteric bud (UB) branching morphogenesis. DOT1 Like (DOT1L), a histone methyltransferase specific for Histone 3 lysine 79 (H3K79), is important for differentiation of the UB-derived renal collecting ...
Song R, Yosypiv IV.
europepmc   +2 more sources

GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions. [PDF]

Biol Res
During diabetes, prorenin is highly produced by the renal collecting ducts. The binding of prorenin to (pro)renin receptor (PRR) on the apical plasma membrane triggers intracellular profibrotic genes, including TGF-β and CTGF.
Larenas PE, Cárdenas P, Aguirre-Delgadillo M, Moris C, Casarini DE, Vallotton Z, Prieto MC, Gonzalez AA.   +7 more
europepmc   +2 more sources