Results 11 to 20 of about 1,765 (116)
Vacuolar H<sup>+</sup>-ATPase and Megalin-Mediated Prorenin Uptake: Focus on Elements Beyond the (Pro)Renin Receptor. [PDF]
J Cell PhysiolABSTRACT Megalin is a multiple‐ligand receptor that contributes to protein reabsorption in the kidney. Recently, megalin was found to act as a novel endocytic receptor for prorenin. Internalization depended on the (pro)renin receptor. This receptor is an accessory protein of vacuolar H+‐ATPase (V‐ATPase), a complex consisting of 14 subunits and two ...
Wang N, Lu X, Jan Danser AH.
europepmc +2 more sources
Prorenin receptor is essential for normal podocyte structure and function. [PDF]
J Am Soc Nephrol, 2011 The prorenin receptor is an accessory subunit of the vacuolar H(+)-ATPase, suggesting that it has fundamental functions beyond activation of the local renin-angiotensin system. Podocytes express the prorenin receptor, but its function in these cells is unknown. Here, podocyte-specific, conditional, prorenin receptor-knockout mice died of kidney failure
Oshima Y +14 more
europepmc +4 more sources
Prorenin receptor regulates more than the renin-angiotensin system
Annals of Medicine, 2012 The (pro)renin receptor (PRR) was initially believed to be a contributor to the pathogenesis of cardiovascular diseases via the amplification of renin- or prorenin-induced angiotensin (Ang) formation. However, a recent paradigm shift suggests a new role for PRR, separate from the renin-angiotensin system (RAS), in contributing to cellular homeostasis ...
Dominik N Müller, Katrina J Binger
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Soluble Prorenin Receptor Increases Blood Pressure in High Fat–Fed Male Mice [PDF]
Hypertension, 2019 Eva Gatineau +2 more
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Journal of the American Society of Nephrology, 2011 The discovery of the prorenin receptor, now nearly a decade ago, altered our view of the renin-angiotensin system (RAS).[1][1],[2][2] Binding of prorenin, the inactive precursor of renin, to the prorenin receptor results in full catalytic activity of prorenin through a nonproteolytic mechanism ...
Meima, Marcel, Danser, Jan
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American Journal of Physiology - Renal Physiology, 2018 Nirupama Ramkumar +2 more
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Prorenin and Its Ancient Receptor [PDF]
Hypertension, 2006 Prorenin, the precursor of renin, has for a long time been considered to be functionally inert, despite high circulating concentrations. Plasma levels of prorenin usually exceed renin levels and are even further increased under pathological conditions, such as in diabetes.
Céline, Burcklé, Michael, Bader
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Hypertension, 2020 Megalin is an endocytic receptor contributing to protein reabsorption. Impaired expression or trafficking of megalin increases urinary renin and allowed the detection of prorenin, which normally is absent in urine. Here, we investigated (pro)renin uptake by megalin, using both conditionally immortalized proximal tubule epithelial cells and Brown Norway
Sun, Yuan +6 more
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The macula densa prorenin receptor is essential in renin release and blood pressure control
American Journal of Physiology - Renal Physiology, 2018 Arnold Sipos, Agnes Prókai, Xin Chen
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Renin, Prorenin and the Putative (Pro)renin Receptor [PDF]
Hypertension, 2005 Renin is an aspartic protease that consists of 2 homologous lobes. The cleft in between contains the active site with 2 catalytic aspartic residues.1 Unlike other aspartic proteases such as pepsin or cathepsin D, renin is monospecific and only cleaves angiotensinogen, to generate angiotensin (Ang) I.
Danser, A.H., Deinum, J.
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