Results 41 to 50 of about 3,903,665 (206)
(Pro)renin receptor and prorenin: their plausible sites of interaction
Frontiers in Bioscience - Landmark, 2012 Before discovery of (pro)renin receptor, prorenin was regarded as a source of renin and probable diagnostic marker for diabetic nephropathy/Wilms' tumor. It is now considered that prorenin can perform renin activity by binding to (P)RR and binding mechanism of (pro)renin to (P)RR was indicated in many in vitro studies.
Ahm Nurun Nabi +2 more
exaly +3 more sources
Urinary prorenin/renin and soluble prorenin receptor excretion in Type 1 and Type 2 diabetes
The FASEB Journal, 2019 Background Activation of the intra‐renal, rather than systemic, renin angiotensin system (RAS) has been suggested to play a role in the development of diabetic kidney disease. In this study, we examined plasma and urinary prorenin/renin levels and urinary soluble prorenin receptor (sPRR) levels in mice with ...
Nirupama Ramkumar +2 more
openaire +2 more sources
Journal of the American Society of Nephrology, 2011 The discovery of the prorenin receptor, now nearly a decade ago, altered our view of the renin-angiotensin system (RAS).[1][1],[2][2] Binding of prorenin, the inactive precursor of renin, to the prorenin receptor results in full catalytic activity of prorenin through a nonproteolytic mechanism ...
Meima, Marcel, Danser, Jan
openaire +3 more sources
High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. [PDF]
PLoS ONE, 2015 It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake.
Yuka Hayakawa +13 more
doaj +1 more source
Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet-Dependent Thrombin Formation and Release of Profibrotic TGF-β. [PDF]
FASEB JPlatelets interact with extracellular vesicles shed by hepatic stellate cells to activate both cell types. Extracellular vesicles shed by activated hepatic stellate cells contain inactive prorenin. HSC‐EV interact with quiescent platelets to non‐proteolytically activate ligated prorenin.
Chen R +8 more
europepmc +2 more sources
Prorenin and Its Ancient Receptor [PDF]
Hypertension, 2006 Prorenin, the precursor of renin, has for a long time been considered to be functionally inert, despite high circulating concentrations. Plasma levels of prorenin usually exceed renin levels and are even further increased under pathological conditions, such as in diabetes.
Céline, Burcklé, Michael, Bader
openaire +2 more sources
Journal of Gynecology Obstetrics and Human Reproduction, 2021 OBJECTIVE The proprotein convertase furin is known to be involved in the processing of pro-B-type natriuretic peptide (proBNP) and prorenin receptor (PRR), suggesting that it has a potential function in blood pressure regulation. We investigated the role
Akiko Ohwaki +9 more
semanticscholar +1 more source
Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy. [PDF]
PLoS ONE, 2017 (Pro)renin receptor [(P)RR], a new component of the tissue renin-angiotensin system (RAS), plays a crucial role in inflammation and angiogenesis in the eye, thus contributing to the development of proliferative diabetic retinopathy (PDR).
Keitaro Hase +4 more
doaj +1 more source
Prorenin, its maturation and the (pro)renin receptor [PDF]
, 2007 The renin-angiotensin system (RAS) is a key biochemical pathway controlling homeostasis and blood pressure. The initial step of the RAS is carried out by renin to produce angiotensin (Ang) I which is converted to Angll by the angiotensin-converting ...
L'Huillier, Nathalie
core +3 more sources