Results 41 to 50 of about 1,765 (116)

(Pro)renin receptor and prorenin: their plausible sites of interaction

Frontiers in Bioscience, 2012
Before discovery of (pro)renin receptor, prorenin was regarded as a source of renin and probable diagnostic marker for diabetic nephropathy/Wilms' tumor. It is now considered that prorenin can perform renin activity by binding to (P)RR and binding mechanism of (pro)renin to (P)RR was indicated in many in vitro studies.
A H M Nurun, Nabi, Kazal Boron, Biswas, Yoshie, Arai, Tsutomu, Nakagawa, Akio, Ebihara, Laila N, Islam, Fumiaki, Suzuki   +6 more
openaire   +2 more sources

Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies

Journal of Cellular and Molecular Medicine, Volume 28, Issue 17, September 2024.
Abstract Cathepsin B (CTSB) is a member of the cysteine protease family, primarily responsible for degrading unnecessary organelles and proteins within the acidic milieu of lysosomes to facilitate recycling. Recent research has revealed that CTSB plays a multifaceted role beyond its function as a proteolytic enzyme in lysosomes.
Zhulan Cai, Shunyao Xu, Chen Liu
wiley   +1 more source

Wnt signaling in cell adhesion, development, and colon cancer

IUBMB Life, Volume 76, Issue 7, Page 383-396, July 2024.
Abstract Wnt signaling is essential for embryonic development, influencing processes such as axis formation, cell proliferation and differentiation, cell fate decisions, and axon guidance. It also plays a role in maintaining tissue homeostasis in adult organisms.
Nydia Tejeda‐Muñoz, Kuo‐Ching Mei
wiley   +1 more source

Vacuolar H+‐ATPase in Diabetes, Hypertension, and Atherosclerosis

Microcirculation, Volume 31, Issue 5, July 2024.
ABSTRACT Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It acts as a proton pump and as such is responsible for regulating pH in lysosomes, endosomes, and the extracellular space.
Na Wang, Liwei Ren, A. H. Jan Danser
wiley   +1 more source

The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat?

Journal of Cellular and Molecular Medicine, Volume 28, Issue 12, June 2024.
Abstract Parkinson disease (PD) is one of the most common neurodegenerative diseases of the brain. Of note, brain renin‐angiotensin system (RAS) is intricate in the PD neuropathology through modulation of oxidative stress, mitochondrial dysfunction and neuroinflammation.
Zainah Al‐Qahtani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Naif H. Ali, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El‐Saber Batiha   +8 more
wiley   +1 more source

The early dorsal signal in vertebrate embryos requires endolysosomal membrane trafficking

BioEssays, Volume 46, Issue 1, January 2024.
Dorsal axis development in Xenopus requires an early Wnt‐like signal that stabilizes β‐catenin. We review experiments showing that a membrane protein called Huluwa and lysosomes are more active on the dorsal side. The graphical abstract shows multivesicular bodies enriched specifically in at the dorsal side of the 64‐cell embryo. Abstract Fertilization
Yagmur Azbazdar, Edward M. De Robertis
wiley   +1 more source

Cleavage of the V-ATPase associated prorenin receptor is mediated by PACE4 and is essential for growth of prostate cancer cells. [PDF]

PLoS One, 2023
Mohammad AH, Couture F, Gamache I, Chen O, El-Assaad W, Abdel-Malak N, Kwiatkowska A, Muller W, Day R, Teodoro JG.   +9 more
europepmc   +1 more source

Species specificity of prorenin binding to the pro renin receptor in vitro

Frontiers in Bioscience, 2010
In this study, binding properties of human prorenin to rat (pro)renin receptor (r(P)RR) and rat prorenin to human (pro)renin receptor (h(P)RR) were elucidated in vitro to investigate species specificity of prorenin bindings to (P)RR. Both (P)RRs were expressed in vitro based on wheat germ lysate and purified using His trap column.
Kazal Boron, Biswas, A H M Nurun, Nabi, Yoshie, Arai, Tsutomu, Nakagawa, Akio, Ebihara, Fumiaki, Suzuki   +5 more
openaire   +2 more sources

Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension. [PDF]

Function (Oxf), 2023
Mathieu NM, Fekete EM, Muskus PC, Brozoski DT, Lu KT, Wackman KK, Gomez J, Fang S, Reho JJ, Grobe CC, Vazirabad I, Mouradian GC, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P.   +16 more
europepmc   +1 more source

Urinary prorenin/renin and soluble prorenin receptor excretion in Type 1 and Type 2 diabetes

The FASEB Journal, 2019
Background Activation of the intra‐renal, rather than systemic, renin angiotensin system (RAS) has been suggested to play a role in the development of diabetic kidney disease. In this study, we examined plasma and urinary prorenin/renin levels and urinary soluble prorenin receptor (sPRR) levels in mice with ...
Nirupama Ramkumar, Deborah Stuart, Donald Kohan   +2 more
openaire   +1 more source