Results 61 to 70 of about 3,903,665 (206)

Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the prorenin receptor

, 2011
The discovery of a specific prorenin receptor has opened to a possible biological function of prorenin independently from angiotensin I production. In the present study we show that prorenin receptor is expressed in normal human vessels (mammary arteries
C. M. Greco, M.L. Gelmi, N. Ferri, M. Camera, L. Facchinetti, A. Corsini, E. Tremoli, M. Brambilla, S. Pellegrino   +8 more
core   +3 more sources

A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation

Molecular Therapy: Nucleic Acids, 2017
The receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to the (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling.
Atsuhiro Kanda, Erdal Tan Ishizuka, Atsushi Shibata, Takahiro Matsumoto, Hidekazu Toyofuku, Kousuke Noda, Kenichi Namba, Susumu Ishida   +7 more
doaj   +1 more source

(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet–Induced Hepatic Steatosis

Biomolecules, 2023
Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism ...
Ariana Julia B. Gayban, Lucas A. C. Souza, Silvana G. Cooper, Erick Regalado, Robert Kleemann, Yumei Feng Earley   +5 more
doaj   +1 more source

Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor

Molecular Therapy: Nucleic Acids, 2019
The receptor-associated prorenin system refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent signaling, and its activation contributes to
Ye Liu, Atsuhiro Kanda, Di Wu, Erdal Tan Ishizuka, Satoru Kase, Kousuke Noda, Atsuhiro Ichihara, Susumu Ishida   +7 more
doaj   +1 more source

(Pro)renin receptor: Involvement in diabetic retinopathy and development of molecular targeted therapy

Journal of Diabetes Investigation, 2019
The renin–angiotensin system (RAS), a crucial regulator of systemic blood pressure (circulatory RAS), plays distinct roles in pathological angiogenesis and inflammation in various organs (tissue RAS), such as diabetic microvascular complications.
Atsuhiro Kanda, Susumu Ishida
doaj   +1 more source

The Prorenin Receptor and its Soluble Form Contribute to Lipid Homeostasis

bioRxiv, 2020
Obesity is associated with alterations in hepatic lipid metabolism. We previously identified the prorenin receptor (PRR) as a potential contributor to liver steatosis. Therefore, we aimed to determine the relative contribution of PRR and its soluble form,
E. Gatineau, Gertrude Arthur, Audrey Poupeau, Kellea Nichols, B. Spear, G. Graf, Ryan E. Temel, Frederique Yiannikouris   +7 more
semanticscholar   +1 more source

Autophagy and the (pro)renin receptor

Frontiers in Endocrinology, 2013
The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure.
Katrina Jean Binger, Dominik N Muller
doaj   +1 more source

Combined renin inhibition/(pro)renin receptor blockade in diabetic retinopathy--a study in transgenic (mREN2)27 rats.

PLoS ONE, 2014
Dysfunction of renin-angiotensin system (RAS) contributes to the pathogenesis of diabetic retinopathy (DR). Prorenin, the precursor of renin is highly elevated in ocular fluid of diabetic patients with proliferative retinopathy.
Wendy W Batenburg, Amrisha Verma, Yunyang Wang, Ping Zhu, Mieke van den Heuvel, Richard van Veghel, A H Jan Danser, Qiuhong Li   +7 more
doaj   +1 more source

Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems

Lipids in Health and Disease, 2018
Background Hypertension may result from high-fat (HF) diet induced-obesity and overexposure to glucocorticoids in utero. Recent studies demonstrated the potent contribution of adipose tissue’s renin-angiotensin system (RAS) to systemic RAS, which plays a
Hong-Ren Yu, You-Lin Tain, Mao-Meng Tiao, Chih-Cheng Chen, Jiunn-Ming Sheen, I-Chun Lin, Shih-Wen Li, Ching-Chou Tsai, Yu-Ju Lin, Kai-Sheng Hsieh, Li-Tung Huang   +10 more
doaj   +1 more source

Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats [PDF]

, 2006
Increased macula densa cyclooxygenase-2 (COX-2) is observed in diabetic rats and may contribute to hyperfiltration states. However, the signals mediating increased COX-2 expression in diabetic rats remain undetermined.
Nakagawa, T., Takemitsu, T., Inagami, T., Suzuki, F., Hayashi, M., Sakoda, M., Kaneshiro, Y., Ichihara, A.   +7 more
core   +1 more source