Immunohistochemistry for (Pro)renin Receptor in Humans [PDF]
International Journal of Endocrinology, 2021 The (pro)renin receptor is a multifunctional protein with roles in angiotensin-II-dependent and -independent intracellular cell signaling and roles as an intracellular accessory protein for the vacuolar H+-ATPase, including hormone secretion.
Satoshi Morimoto +5 more
doaj +5 more sources
Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts [PDF]
Scientific Reports, 2021 The (pro)renin receptor (PRR) is a multifunctional integral membrane protein that serves as a component of the vacuolar H+-ATPase (V-ATPase) and also activates (pro)renin.
Jonathan B. Murray +5 more
doaj +5 more sources
Adrenal (Pro)renin Receptor Expression and Serum Soluble (Pro)renin Receptor Concentration in Primary Aldosteronism [PDF]
International Journal of Endocrinology, 2020 The (pro)renin receptor [(P)RR] is a multifunctioning protein playing roles in various pathological conditions. A soluble form of (P)RR [s(P)RR] has been considered a biomarker for (P)RR expression in tissues.
Daisuke Watanabe +6 more
doaj +4 more sources
Autophagy and the (pro)renin receptor [PDF]
Frontiers in Endocrinology, 2013 The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure.
Katrina Jean Binger, Dominik N Muller
doaj +6 more sources
The role of (pro)renin receptor and its soluble form in cardiovascular diseases [PDF]
Frontiers in Cardiovascular Medicine, 2023 The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (
Boyang Wang +9 more
doaj +2 more sources
The relationship between kidney function and the soluble (pro)renin receptor in young adults: the African-PREDICT study [PDF]
BMC NephrologyHigh renin angiotensin-aldosterone system (RAAS) activity is associated with target organ damage. Soluble (pro)renin receptor [s(P)RR] forms part of the RAAS cascade and is associated with kidney damage through both angiotensin II-dependent and ...
Phuti J. Mokgonyana +3 more
doaj +2 more sources
Soluble (Pro)Renin Receptor Levels Are Regulated by Plasma Renin Activity and Correlated with Edema in Mice and Humans with HFrEF [PDF]
Biomedicines, 2022 Symptomatic heart failure with reduced ejection fraction (HFrEF) is characterized by edema and chronic pathological activation of the classical renin–angiotensin–aldosterone system (RAAS).
Inna P. Gladysheva +3 more
doaj +2 more sources
Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis [PDF]
Scientific Reports, 2023 Glioblastoma is characterized by a strong self-renewal potential and poor differentiated state. We have reported previously that the (pro)renin receptor [(P)RR] is a potential target for glioma therapy by silencing the (P)RR gene.
Takeshi Fujimori +10 more
doaj +2 more sources
(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet–Induced Hepatic Steatosis [PDF]
Biomolecules, 2023 Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism ...
Ariana Julia B. Gayban +5 more
doaj +2 more sources
Assessment of the (Pro)renin Receptor Protein Expression in Organs [PDF]
Current Issues in Molecular BiologyThe (pro)renin receptor ((P)RR) is an essential component of the renin–angiotensin system (RAS) as a specific single-pass transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of ...
Teng-Yao Yang +4 more
doaj +2 more sources