Results 1 to 10 of about 307 (113)
Autophagy and the (pro)renin receptor [PDF]
Frontiers in Endocrinology, 2013 The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure.
Katrina Jean Binger, Dominik N Muller
doaj +6 more sources
Immunohistochemistry for (Pro)renin Receptor in Humans [PDF]
International Journal of Endocrinology, 2021 The (pro)renin receptor is a multifunctional protein with roles in angiotensin-II-dependent and -independent intracellular cell signaling and roles as an intracellular accessory protein for the vacuolar H+-ATPase, including hormone secretion.
Satoshi Morimoto +5 more
doaj +3 more sources
Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts [PDF]
Scientific Reports, 2021 The (pro)renin receptor (PRR) is a multifunctional integral membrane protein that serves as a component of the vacuolar H+-ATPase (V-ATPase) and also activates (pro)renin.
Jonathan B. Murray +5 more
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International Journal of Endocrinology, 2020 The (pro)renin receptor [(P)RR] is a multifunctioning protein playing roles in various pathological conditions. A soluble form of (P)RR [s(P)RR] has been considered a biomarker for (P)RR expression in tissues.
Daisuke Watanabe +6 more
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Renin, Prorenin and the Putative (Pro)renin Receptor [PDF]
Hypertension, 2005 Renin is an aspartic protease that consists of 2 homologous lobes. The cleft in between contains the active site with 2 catalytic aspartic residues.1 Unlike other aspartic proteases such as pepsin or cathepsin D, renin is monospecific and only cleaves angiotensinogen, to generate angiotensin (Ang) I.
Danser, A.H., Deinum, J.
+8 more sources
Antioxidants, 2021 Dysregulation of the tissue renin–angiotensin system (RAS) is involved in tissue oxidative and inflammatory responses. Among RAS components, renin, its precursor (pro)renin and its specific receptor (PRR) have been less investigated, particularly in the ...
Andrea Lopez-Lopez +7 more
doaj +1 more source
Elevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia [PDF]
American Journal of Hypertension, 2015 Preeclampsia (preE), a syndrome of hypertension, proteinuria, and edema, has many elusive triggers. The renin-angiotensin system has been implicated in preE pathogenesis. In this study, we test the hypothesis that (pro)renin levels are increased in preE patients and that levels of (pro)renin and (pro)renin receptor ((P)RR) are elevated in a rat model ...
Jessica, Thomason +7 more
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The Biology of the (Pro)Renin Receptor [PDF]
Journal of the American Society of Nephrology, 2010 The (pro)renin receptor (PRR) binds renin and prorenin, its proenzyme inactive form. Receptor-bound prorenin becomes enzymatically active and binding then activates the MAP kinases ERK1/2 and p38 pathways, leading to upregulation of profibrotic and cyclooxygenase-2 genes independent of angiotensin II generation.
Genevieve, Nguyen, Dominik N, Muller
openaire +2 more sources
Ontogeny of the (pro)renin receptor [PDF]
Pediatric Research, 2013 This study examined temporal expression of the (pro)renin receptor ((P)RR), during renal, heart, lung, and brain organogenesis in the mouse.(P)RR expression was determined by quantitative reverse-transcription PCR, western blotting, and immunohistochemistry.Brain, kidney, and lung (P)RR mRNA levels increased progressively during gestation and peak on ...
Renfang, Song +2 more
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High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. [PDF]
PLoS ONE, 2015 It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake.
Yuka Hayakawa +13 more
doaj +1 more source