Immunohistochemistry for (Pro)renin Receptor in Humans [PDF]
International Journal of Endocrinology, 2021 The (pro)renin receptor is a multifunctional protein with roles in angiotensin-II-dependent and -independent intracellular cell signaling and roles as an intracellular accessory protein for the vacuolar H+-ATPase, including hormone secretion.
Satoshi Morimoto +5 more
doaj +6 more sources
The role of (pro)renin receptor and its soluble form in cardiovascular diseases [PDF]
Frontiers in Cardiovascular Medicine, 2023 The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (
Boyang Wang +9 more
doaj +3 more sources
Soluble (Pro)Renin Receptor in Hypertension. [PDF]
Nephron, 2023 The (pro)renin receptor (PRR) was originally cloned as a specific single-transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physiopathological processes ...
Yang T.
europepmc +4 more sources
Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis [PDF]
Scientific Reports, 2023 Glioblastoma is characterized by a strong self-renewal potential and poor differentiated state. We have reported previously that the (pro)renin receptor [(P)RR] is a potential target for glioma therapy by silencing the (P)RR gene.
Takeshi Fujimori +10 more
doaj +3 more sources
Soluble (pro)renin receptor as a novel laboratory biomarker of atherosclerosis [PDF]
Acta Biochimica et Biophysica SinicaAtherosclerosis (AS), a chronic inflammatory disease involving the large and middle arteries, is characterized by inflammation, abnormal deposition of lipids, and other pathological events [1].
Liu Chunju +10 more
doaj +3 more sources
Soluble (Pro)Renin Receptor Levels Are Regulated by Plasma Renin Activity and Correlated with Edema in Mice and Humans with HFrEF [PDF]
Biomedicines, 2022 Symptomatic heart failure with reduced ejection fraction (HFrEF) is characterized by edema and chronic pathological activation of the classical renin–angiotensin–aldosterone system (RAAS).
Inna P. Gladysheva +3 more
doaj +3 more sources
(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet–Induced Hepatic Steatosis [PDF]
Biomolecules, 2023 Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism ...
Ariana Julia B. Gayban +5 more
doaj +3 more sources
(Pro)renin receptor promotes colorectal cancer progression through inhibiting the NEDD4L-mediated Wnt3 ubiquitination and modulating gut microbiota. [PDF]
Cell Commun Signal, 2023 Background We previously found that (pro)renin receptor ((P)RR) augments Wnt3 protein without affecting Wnt3 gene transcription in colorectal cancer (CRC) cells, thus contributes to CRC initiation.
Wang J +5 more
europepmc +2 more sources
Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies. [PDF]
Curr Hypertens RepFor a healthy pregnancy to occur, a controlled interplay between the maternal circulating renin–angiotensin–aldosterone system (RAAS), placental renin-angiotensin system (RAS) and intrarenal renin-angiotensin system (iRAS) is necessary.
Schofield LG +4 more
europepmc +2 more sources
(Pro)renin receptor mediates tubular epithelial cell pyroptosis in diabetic kidney disease via DPP4-JNK pathway. [PDF]
J Transl MedBackground (Pro)renin receptor (PRR) is highly expressed in renal tubules, which is involved in physiological and pathological processes. However, the role of PRR, expressed in renal tubular epithelial cells, in diabetic kidney disease (DKD) remain ...
Xie S +6 more
europepmc +2 more sources