Results 41 to 50 of about 32,074 (246)

中枢神经系统肾素（原）受体参与高血压发病机制的研究进展 Progress of Central Nervous System (Pro) Renin Receptor in the Pathogenesis of Hypertension

Zhongguo cuzhong zazhi, 2019
肾素（原）受体是由ATP6AP2基因编码、350个氨基酸组成的Ⅰ型单次跨膜蛋白，广泛存在 于多种组织器官中，并在大脑中高度表达。中枢神经系统肾素（原）受体与高血压密切相关，并通过 促进血管紧张素Ⅱ形成的肾素-血管紧张素系统机制以及其他非肾素-血管紧张素系统机制参与血压 调节。中枢神经系统肾素（原）受体有可能成为高血压治疗新靶点。 Abstract: The (pro) renin receptor is a type I single transmembrane protein composed
唐欣颖，匡泽民，卢玺峰
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Plasma Soluble (Pro)renin Receptor Reflects Renal Damage.

PLoS ONE, 2016
Background(Pro)renin receptor [(P)RR], a specific receptor for renin and prorenin, was identified as a member of the renin-angiotensin system (RAS). (P)RR is cleaved by furin, and soluble (P)RR [s(P)RR] is secreted into the extracellular space.
Naro Ohashi, Shinsuke Isobe, Sayaka Ishigaki, Takahisa Suzuki, Takamasa Iwakura, Masafumi Ono, Tomoyuki Fujikura, Takayuki Tsuji, Atsushi Otsuka, Yasuo Ishii, Hiroshi Furuse, Akihiko Kato, Seiichiro Ozono, Hideo Yasuda   +13 more
doaj   +1 more source

Superimposing a high-fat diet on Schistosoma mansoni infection affects renin-angiotensin system components in the mouse kidney

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: The levels of the full-length form of the (pro)renin receptor (PRR), a component of the renin-angiotensin system (RAS), may be reduced in the membranes of kidneys in renal diseases.
Danielle Guedes Dantas Lira, Danielly Cantarelli de Oliveira, Fábio André Brayner, André de Lima Aires, Mônica Camelo Pessoa A. Albuquerque, Leucio Duarte Vieira, Célia Maria Machado Barbosa de Castro, Ana Durce Paixão   +7 more
doaj   +1 more source

(Pro)renin receptor and autophagy in podocytes [PDF]

Autophagy, 2012
Within the kidneys, podocytes are highly specialized postmitotic cells. Podocytes, together with endothelial cells and the glomerular basement membrane (GBM), maintain the filtration barrier and the normal structure of the glomerular capillary, are involved in the remodeling of the GBM and the endocytosis of filtered proteins, and counteract ...
openaire   +2 more sources

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, EarlyView.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

(Pro)renin Receptor in Kidney Development and Disease

International Journal of Nephrology, 2011
The renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. All the components of the RAS are expressed in the developing metanephros.
Renfang Song, Ihor V. Yosypiv
doaj   +1 more source

Soluble (pro)renin receptor in elderly chronic heart failure patients

Frontiers in Bioscience-Landmark, 2020
Overactivation of renin-angiotensin system (RAS) is one of the main pathophysiological features in the evolution of chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player in a tissue renin-angiotensin system (tissue ...
Danilo Obradovic, Goran Loncar, Sara Radenovic, Elvis Tahirovic, Harald Heidecke, Kai Schulze-Forster, Dominik Muller, Andreas Busjahn, Petra Buttner, Jovan Veskovic, Marija Zdravkovic, Haluo Li, Simin Li, Vuk Savkovic, Burkert Pieske, Hans-Dirk Dungen, Ralf Dechend   +16 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor

Molecular Therapy: Nucleic Acids, 2019
The receptor-associated prorenin system refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent signaling, and its activation contributes to
Ye Liu, Atsuhiro Kanda, Di Wu, Erdal Tan Ishizuka, Satoru Kase, Kousuke Noda, Atsuhiro Ichihara, Susumu Ishida   +7 more
doaj   +1 more source