Results 41 to 50 of about 2,679,159 (249)

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

中枢神经系统肾素（原）受体参与高血压发病机制的研究进展 Progress of Central Nervous System (Pro) Renin Receptor in the Pathogenesis of Hypertension

Zhongguo cuzhong zazhi, 2019
肾素（原）受体是由ATP6AP2基因编码、350个氨基酸组成的Ⅰ型单次跨膜蛋白，广泛存在 于多种组织器官中，并在大脑中高度表达。中枢神经系统肾素（原）受体与高血压密切相关，并通过 促进血管紧张素Ⅱ形成的肾素-血管紧张素系统机制以及其他非肾素-血管紧张素系统机制参与血压 调节。中枢神经系统肾素（原）受体有可能成为高血压治疗新靶点。 Abstract: The (pro) renin receptor is a type I single transmembrane protein composed
唐欣颖，匡泽民，卢玺峰
doaj   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Plasma Soluble (Pro)renin Receptor Reflects Renal Damage.

PLoS ONE, 2016
Background(Pro)renin receptor [(P)RR], a specific receptor for renin and prorenin, was identified as a member of the renin-angiotensin system (RAS). (P)RR is cleaved by furin, and soluble (P)RR [s(P)RR] is secreted into the extracellular space.
Naro Ohashi, Shinsuke Isobe, Sayaka Ishigaki, Takahisa Suzuki, Takamasa Iwakura, Masafumi Ono, Tomoyuki Fujikura, Takayuki Tsuji, Atsushi Otsuka, Yasuo Ishii, Hiroshi Furuse, Akihiko Kato, Seiichiro Ozono, Hideo Yasuda   +13 more
doaj   +1 more source

Superimposing a high-fat diet on Schistosoma mansoni infection affects renin-angiotensin system components in the mouse kidney

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: The levels of the full-length form of the (pro)renin receptor (PRR), a component of the renin-angiotensin system (RAS), may be reduced in the membranes of kidneys in renal diseases.
Danielle Guedes Dantas Lira, Danielly Cantarelli de Oliveira, Fábio André Brayner, André de Lima Aires, Mônica Camelo Pessoa A. Albuquerque, Leucio Duarte Vieira, Célia Maria Machado Barbosa de Castro, Ana Durce Paixão   +7 more
doaj   +1 more source

(Pro)renin receptor and autophagy in podocytes [PDF]

Autophagy, 2012
Within the kidneys, podocytes are highly specialized postmitotic cells. Podocytes, together with endothelial cells and the glomerular basement membrane (GBM), maintain the filtration barrier and the normal structure of the glomerular capillary, are involved in the remodeling of the GBM and the endocytosis of filtered proteins, and counteract ...
openaire   +2 more sources

Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells [PDF]

, 1991
Utilizing cocultures of mouse renal juxtaglomerular cells with bovine microvascular endothelial cells, we have examined whether endothelial cells exert direct influence on renin secretion from renal juxtaglomerular cells.
Kaissling, Brigitte, Kurtz, Armin, Baier, Wolfgang, W Baier, R Busse, A Kurtz, Busse, Rudi, B Kaissling   +7 more
core   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

(Pro)renin Receptor in Kidney Development and Disease

International Journal of Nephrology, 2011
The renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. All the components of the RAS are expressed in the developing metanephros.
Renfang Song, Ihor V. Yosypiv
doaj   +1 more source

Soluble (pro)renin receptor in elderly chronic heart failure patients

Frontiers in Bioscience-Landmark, 2020
Overactivation of renin-angiotensin system (RAS) is one of the main pathophysiological features in the evolution of chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player in a tissue renin-angiotensin system (tissue ...
Danilo Obradovic, Goran Loncar, Sara Radenovic, Elvis Tahirovic, Harald Heidecke, Kai Schulze-Forster, Dominik Muller, Andreas Busjahn, Petra Buttner, Jovan Veskovic, Marija Zdravkovic, Haluo Li, Simin Li, Vuk Savkovic, Burkert Pieske, Hans-Dirk Dungen, Ralf Dechend   +16 more
doaj   +1 more source