Results 41 to 50 of about 142,423 (312)

Soluble (Pro)Renin Receptor Induces Endothelial Dysfunction and Hypertension in Mice with Diet-Induced Obesity via Activation of Angiotensin II Type 1 Receptor

Clinical science, 2021
Until now, renin-angiotensin system (RAS) hyperactivity was largely thought to result from angiotensin II (Ang II) dependent stimulation of the Ang II type 1 receptor (AT1R).
Ziwei Fu, Fei Wang, Xiyang Liu, Jiajia Hu, Jiahui Su, Xiaohan Lu, Aihua Lu, Jae-min Cho, J., David J. Symons, Chang-jiang Zou, Tianxin Yang   +11 more
semanticscholar   +1 more source

NADPH-Oxidase, Rho-Kinase and Autophagy Mediate the (Pro)renin-Induced Pro-Inflammatory Microglial Response and Enhancement of Dopaminergic Neuron Death

Antioxidants, 2021
Dysregulation of the tissue renin–angiotensin system (RAS) is involved in tissue oxidative and inflammatory responses. Among RAS components, renin, its precursor (pro)renin and its specific receptor (PRR) have been less investigated, particularly in the ...
Andrea Lopez-Lopez, Begoña Villar-Cheda, Aloia Quijano, Pablo Garrido-Gil, María Garcia-Garrote, Carmen Díaz-Ruiz, Ana Muñoz, José L. Labandeira-Garcia   +7 more
doaj   +1 more source

Elevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia [PDF]

American Journal of Hypertension, 2015
Preeclampsia (preE), a syndrome of hypertension, proteinuria, and edema, has many elusive triggers. The renin-angiotensin system has been implicated in preE pathogenesis. In this study, we test the hypothesis that (pro)renin levels are increased in preE patients and that levels of (pro)renin and (pro)renin receptor ((P)RR) are elevated in a rat model ...
Jessica, Thomason, Michelle, Reyes, Steven R, Allen, Richard O, Jones, Madhava R, Beeram, Thomas J, Kuehl, Fumiaki, Suzuki, Mohammad Nasir, Uddin   +7 more
openaire   +2 more sources

Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.

Placenta, 2023
INTRODUCTION Preeclampsia (PE) pathogenesis is explained by the two-stage disorder theory. However, mechanisms underlying hypertension and proteinuria in PE remain unclear.
Sakurako Mishima, T. Mitsui, Kazumasa Tani, Hikaru Ooba, T. Mitoma, Akiko Ohira, J. Maki, Satoe Kirino, Eriko Eto, K. Hayata, H. Masuyama   +10 more
semanticscholar   +1 more source

Functions of the (pro)renin receptor (Atp6ap2) at molecular and system levels: pathological implications in hypertension, renal and brain development, inflammation, and fibrosis.

Pharmacological Research, 2021
The (pro)renin receptor [(P)RR, Atp6ap2] was initially discovered as a membrane-bound binding partner of prorenin and renin. A soluble (P)RR has additional paracrine effects and is involved in metabolic syndrome and kidney damage.
Nadin Hoffmann, J. Peters
semanticscholar   +1 more source

Ontogeny of the (pro)renin receptor [PDF]

Pediatric Research, 2013
This study examined temporal expression of the (pro)renin receptor ((P)RR), during renal, heart, lung, and brain organogenesis in the mouse.(P)RR expression was determined by quantitative reverse-transcription PCR, western blotting, and immunohistochemistry.Brain, kidney, and lung (P)RR mRNA levels increased progressively during gestation and peak on ...
Renfang, Song, Graeme, Preston, Ihor V, Yosypiv   +2 more
openaire   +2 more sources

Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury

Circulation Research, 2021
Supplemental Digital Content is available in the text. Rationale: Cleavage of the extracellular domain of the PRR ([pro]renin receptor) yields a soluble fragment (sPRR).
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, W. Wheatley, Jae Min Cho, J. Symons, D. Kohan   +7 more
semanticscholar   +1 more source

(Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-β1/SMAD3 Pathway

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims Activation of the (pro)renin receptor (PRR) up-regulates the expression of profibrotic genes in the kidney and heart. We aimed to investigate the role of PRR in hepatic fibrogenesis.
Y. Hsieh, Kuei-Chuan Lee, Hao-Jan Lei, K. Lan, T. Huo, Yi-Tsung Lin, Che-chang Chan, B. Schnabl, Yi‐Hsiang Huang, M. Hou, Han‐Chieh Lin   +10 more
semanticscholar   +1 more source

High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. [PDF]

PLoS ONE, 2015
It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake.
Yuka Hayakawa, Takuma Aoyama, Chiharu Yokoyama, Chihiro Okamoto, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Itta Kawamura, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Fumiaki Suzuki, Shinya Minatoguchi   +13 more
doaj   +1 more source

Drug Discovery for Overcoming Chronic Kidney Disease (CKD): New Therapy for CKD by a (Pro)Renin-Receptor–Blocking Decoy Peptide

Journal of Pharmacological Sciences, 2009
Discovery of the (pro)renin receptor uncovered a novel function of renin/prorenin as the receptor ligands in addition to the enzyme and its precursor.
Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Hiroshi Itoh   +5 more
doaj   +1 more source