Results 61 to 70 of about 2,679,159 (249)

Biochemical properties of renin and prorenin binding to the (pro)renin receptor [PDF]

Hypertension Research, 2009
The discovery of (pro)renin receptor, (P)RR, has made the renin-angiotensin system (RAS) more multifaceted. Interaction of renin and prorenin with this receptor has set a new perspective about the physiological functions, activation mechanism and pathophysiological roles of renin/prorenin.
A H M Nurun, Nabi, Fumiaki, Suzuki
openaire   +2 more sources

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Inhibition of (Pro)renin Receptor-Mediated Oxidative Stress Alleviates Doxorubicin-Induced Heart Failure

Frontiers in Oncology, 2022
AimClinical utility of doxorubicin (DOX) is limited by its cardiotoxic side effect, and the underlying mechanism still needs to be fully elucidated. This research aimed to examine the role of (pro)renin receptor (PRR) in DOX-induced heart failure (HF ...
Xiao-yi Du, Xiao-yi Du, Dao-chun Xiang, Ping Gao, Hua Peng, Ya-li Liu   +5 more
doaj   +1 more source

Prorenin engages the (pro) renin receptor like renin and both ligand activities are unopposed by aliskiren

, 2008
Objectives Inhibition of (pro) renin receptor activation was demonstrated to inhibit or even abolish the development of end-organ damage in animal models.
Goebel, M, Gust, R, Kirsch, S, Kintscher, U, Schefe, JH, Funke-Kaiser, H, Neumann, C, Unger, T, Danser, Jan   +8 more
core   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Direct pro-inflammatory effects of prorenin on microglia.

PLoS ONE, 2014
Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of the ...
Peng Shi, Justin L Grobe, Fiona A Desland, Guannan Zhou, Xiao Z Shen, Zhiying Shan, Meng Liu, Mohan K Raizada, Colin Sumners   +8 more
doaj   +1 more source

Soluble (pro)renin receptor in preeclampsia and diabetic pregnancies

, 2017
Women with preexisting or gestational diabetes mellitus have an increased risk for developing preeclampsia. Diabetes and pregnancy are both characterized by very high prorenin levels and renin-angiotensin system activation.
Florian Herse, Staff, AC, Meryam Sugulle, Mueller, DN, Ralf Dechend, Staff, A.C., Mueller, D.N., Heidecke, H, Heidecke, H., Dechend, R., Danser, Jan, Sugulle, M, Sugulle, M., Ulrike Maschke, A.H. Jan Danser, Harald Heidecke, Maschke, U., Danser, A.H.J., Dechend, R, Maschke, U, Dominik N. Mueller, Anne Cathrine Staff, Herse, F., Herse, F   +23 more
core   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Stimulation of renin secretion by potassium-channel activation with cromakalim [PDF]

, 1989
The cardiovascular and endocrine profile of cromakalim has been studied in 8 healthy men (age 25 +/- 2 years: means SEM) and its influence on renin release from cultured rat juxtaglomerular cells in vitro has also been examined.
Kurtz, Armin, Lehner, P., Shaw, S. G., Weidmann, P., Ferrier, C. P., Pusterla, C., Saxenhofer, H.   +6 more
core   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source