Results 81 to 90 of about 142,423 (312)

Megalin A Novel Endocytic Receptor for Prorenin and Renin [PDF]

, 2020
Megalin is an endocytic receptor contributing to protein reabsorption. Impaired expression or trafficking of megalin increases urinary renin and allowed the detection of prorenin, which normally is absent in urine. Here, we investigated (pro)renin uptake
Sun, Yuan, Masereeuw, R, Van den Berg - Garrelds, Ingrid; id_orcid, Goes Martini, Alexandre, Masereeuw, Rosalinde, Janssen, MJC, Martini, Alexandre, Janssen, Manoe J., Garrelds, Ingrid M., Lu, Xifeng, Van den Berg - Garrelds, Ingrid, Danser, A. H.Jan, Danser, AHJ, Lu, XF   +13 more
core   +1 more source

α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions

Frontiers in Cardiovascular Medicine, 2021
Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na+ handling.
A. Guerrero, B. Visniauskas, Pilar Cárdenas, S. Figueroa, Jorge Vivanco, N. Salinas-Parra, P. Araos, Quynh My Nguyen, M. Kassan, C. Amador, Minolfa C. Prieto, Alexis A Gonzalez   +11 more
semanticscholar   +1 more source

(Pro)renin receptor and autophagy in podocytes [PDF]

Autophagy, 2012
Within the kidneys, podocytes are highly specialized postmitotic cells. Podocytes, together with endothelial cells and the glomerular basement membrane (GBM), maintain the filtration barrier and the normal structure of the glomerular capillary, are involved in the remodeling of the GBM and the endocytosis of filtered proteins, and counteract ...
openaire   +2 more sources

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Plasma Soluble (Pro)renin Receptor Reflects Renal Damage.

PLoS ONE, 2016
Background(Pro)renin receptor [(P)RR], a specific receptor for renin and prorenin, was identified as a member of the renin-angiotensin system (RAS). (P)RR is cleaved by furin, and soluble (P)RR [s(P)RR] is secreted into the extracellular space.
Naro Ohashi, Shinsuke Isobe, Sayaka Ishigaki, Takahisa Suzuki, Takamasa Iwakura, Masafumi Ono, Tomoyuki Fujikura, Takayuki Tsuji, Atsushi Otsuka, Yasuo Ishii, Hiroshi Furuse, Akihiko Kato, Seiichiro Ozono, Hideo Yasuda   +13 more
doaj   +1 more source

Soluble (pro)renin receptor in elderly chronic heart failure patients

Frontiers in Bioscience-Landmark, 2020
Overactivation of renin-angiotensin system (RAS) is one of the main pathophysiological features in the evolution of chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player in a tissue renin-angiotensin system (tissue ...
Danilo Obradovic, Goran Loncar, Sara Radenovic, Elvis Tahirovic, Harald Heidecke, Kai Schulze-Forster, Dominik Muller, Andreas Busjahn, Petra Buttner, Jovan Veskovic, Marija Zdravkovic, Haluo Li, Simin Li, Vuk Savkovic, Burkert Pieske, Hans-Dirk Dungen, Ralf Dechend   +16 more
doaj   +1 more source

Pro-renin receptor (PRR) expression in mouse renal mesangial cells.

, 2019
(A) Pro-renin receptor (PRR) mRNA and (B) protein expression in normal glucose (NG, 25 mmol L-glucose) and high glucose (HG, 25 mmol D-glucose) cultured mRMCs treated with either scramble (Scr) siRNA or PRR siRNA. Western blot analysis of pAMPK and total
Helmy M. Siragy (8082086), Safia Akhtar (8082083)   +1 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, EarlyView.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

(Pro)renin and its receptors: Pathophysiological implications

, 2012
Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin [together denoted as (pro)renin].
Batenburg, Wendy, Danser, A.H.J. (Jan), Batenburg, W.W. (Wendy), Danser, Jan   +3 more
core   +1 more source