Results 101 to 110 of about 142,423 (312)
Inner medullary expression of the (pro)renin receptor.
, 2015 Values are expressed as means ± SE. (P)RR, (pro)renin receptor;n, number of rats.*P
Sophie Constantin Lütken (689916) +2 more
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(Pro)renin Receptor And Its Soluble Form in Metabolic Dysfunction: Friend or Foe?
, 2023 (Pro)renin receptor is component of the renin angiotensin system which has been shown to be involved in several physiological and pathophysiological processes including blood pressure regulation and hypertension, water and electrolyte balance, kidney ...
Arthur, Gertrude
core +1 more source
Biochemical properties of renin and prorenin binding to the (pro)renin receptor [PDF]
Hypertension Research, 2009 The discovery of (pro)renin receptor, (P)RR, has made the renin-angiotensin system (RAS) more multifaceted. Interaction of renin and prorenin with this receptor has set a new perspective about the physiological functions, activation mechanism and pathophysiological roles of renin/prorenin.
A H M Nurun, Nabi, Fumiaki, Suzuki
openaire +2 more sources
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
Direct pro-inflammatory effects of prorenin on microglia.
PLoS ONE, 2014 Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of the ...
Peng Shi +8 more
doaj +1 more source
Biomolecules, 2021 This study investigated the expression of components of the renin-angiotensin system (RAS) by cancer stem cells (CSCs) we have recently demonstrated in renal clear cell carcinoma (RCCC).
Sam Siljee +8 more
doaj +1 more source
, 2011 Renin/prorenin binding to the (pro)renin receptor ([P]RR) results in direct (angiotensin-independent) second-messenger activation in vitro, whereas in vivo studies in rodents overexpressing prorenin (≈400-fold) or the (P)RR do not support such activation.
Batenburg, Wendy +17 more
core +1 more source
Pflügers Archiv: European Journal of Physiology, 2021 The ATP6ap2 (Pro)renin receptor protein associates with H+-ATPases which regulate organellar, cellular, and systemic acid–base homeostasis. In the kidney, ATP6ap2 colocalizes with H+-ATPases in various cell types including the cells of the proximal ...
Marta Figueiredo +8 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber +7 more
wiley +1 more source
(Pro)renin receptors: are they biologically relevant?
, 2009 Purpose of review The recent introduction of a renin inhibitor, aliskiren, into the clinical arena has revived interest in renin and its precursor prorenin.
Danser, Jan
core +1 more source