Results 91 to 100 of about 142,423 (312)

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source

Roles and functions of Atp6ap2 in the brain

Neural Regeneration Research, 2018
The classical renin-angiotensin system (RAS) in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure.
Alexander Bracke, Oliver von Bohlen und Halbach   +1 more
doaj   +1 more source

Expression of cardiac tissue prorenin, renin, (pro)renin receptor, angiotensinogen and angiotensin II AT1 receptor.

, 2015
Expressions of cardiac tissue (a) prorenin, (b) renin, (c) (pro)renin receptor, (d) angiotensinogen and (e) angiotensin AT1 receptor in the WKY + normal-salt group (WKY+NS), WKY + high-salt group (WKY+HS), SHR + normal-salt group (SHR+NS) and SHR + high ...
Takuma Aoyama (675581), Shingo Minatoguchi (709054), Fumiaki Suzuki (709059), Masamitsu Iwasa (709055), Chiharu Yokoyama (675582), Atsushi Mikami (709058), Itta Kawamura (709057), Hisaaki Komaki (709053), Shinya Minatoguchi (675586), Yuka Hayakawa (675583), Masanori Kawasaki (274320), Yoshihisa Yamada (709056), Chihiro Okamoto (709052), Kazuhiko Nishigaki (675585)   +13 more
core   +1 more source

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin Type 2 receptor [PDF]

, 2012
The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor.
Nicklin Stuart A., Almalik Abdulaziz, Bruno M D C Godinho, Flores-Muñoz Monica, Flores-Muñoz, M., Almalik, A., Nicklin, S.A., Monica Flores-Muñoz, Stuart A Nicklin, Abdulaziz Almalik, Godinho, B.M.D.C., Godinho Bruno M. D. C.   +11 more
core   +1 more source

The (pro)renin receptor as a pharmacological target in cardiorenal diseaes

, 2023
The (pro)renin receptor ((P)RR) is not only a member of the renin-angiotensin system (RAS) but also exerts several RAS-independent functions due to its multiple signal transductions pathways.
Heiko Funke-Kaiser, Thomas Unger, Funke-Kaiser, Heiko, Unger, Thomas   +3 more
core   +1 more source

Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney

PLoS ONE, 2019
Abnormal mitochondrial biogenesis and function has been linked to multiple diseases including diabetes. Recently, we demonstrated the role of renal (Pro)renin receptor (PRR) in the dysregulation of mitochondria.
S. Akhtar, H. Siragy
semanticscholar   +1 more source

Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II–Induced Hypertension in Mice

HYPERTENSION, 2020
Supplemental Digital Content is available in the text. Activation of PRR ([pro]renin receptor) contributes to enhancement of intrarenal RAS and renal medullary α-ENaC and thus elevated blood pressure during Ang II (angiotensin II) infusion.
Ye Feng, Kexin Peng, R. Luo, Fei Wang, Tianxin Yang   +4 more
semanticscholar   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

The Neuronal (Pro)renin Receptor and Astrocyte Inflammation in the Central Regulation of Blood Pressure and Blood Glucose in Mice Fed a High-Fat Diet.

American Journal of Physiology. Endocrinology and Metabolism, 2020
We report here that the neuronal (pro)renin receptor (PRR), a key component of the brain renin-angiotensin system (RAS), plays a critical role in the central regulation of high-fat-diet (HFD)-induced metabolic pathophysiology.
Caleb J. Worker, Wencheng Li, Cheng-Yuan Feng, Lucas A. C. Souza, A. Gayban, Silvana G. Cooper, Sanzida Afrin, Samantha S. Romanick, B. Ferguson, Yumei Feng Earley   +9 more
semanticscholar   +1 more source