Results 71 to 80 of about 142,423 (312)

Prorenin engages the (pro) renin receptor like renin and both ligand activities are unopposed by aliskiren

, 2008
Objectives Inhibition of (pro) renin receptor activation was demonstrated to inhibit or even abolish the development of end-organ damage in animal models.
Goebel, M, Gust, R, Kirsch, S, Kintscher, U, Schefe, JH, Funke-Kaiser, H, Neumann, C, Unger, T, Danser, Jan   +8 more
core   +1 more source

Soluble (pro)renin receptor in preeclampsia and diabetic pregnancies

, 2017
Women with preexisting or gestational diabetes mellitus have an increased risk for developing preeclampsia. Diabetes and pregnancy are both characterized by very high prorenin levels and renin-angiotensin system activation.
Florian Herse, Staff, AC, Meryam Sugulle, Mueller, DN, Ralf Dechend, Staff, A.C., Mueller, D.N., Heidecke, H, Heidecke, H., Dechend, R., Danser, Jan, Sugulle, M, Sugulle, M., Ulrike Maschke, A.H. Jan Danser, Harald Heidecke, Maschke, U., Danser, A.H.J., Dechend, R, Maschke, U, Dominik N. Mueller, Anne Cathrine Staff, Herse, F., Herse, F   +23 more
core   +1 more source

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

中枢神经系统肾素（原）受体参与高血压发病机制的研究进展 Progress of Central Nervous System (Pro) Renin Receptor in the Pathogenesis of Hypertension

Zhongguo cuzhong zazhi, 2019
肾素（原）受体是由ATP6AP2基因编码、350个氨基酸组成的Ⅰ型单次跨膜蛋白，广泛存在 于多种组织器官中，并在大脑中高度表达。中枢神经系统肾素（原）受体与高血压密切相关，并通过 促进血管紧张素Ⅱ形成的肾素-血管紧张素系统机制以及其他非肾素-血管紧张素系统机制参与血压 调节。中枢神经系统肾素（原）受体有可能成为高血压治疗新靶点。 Abstract: The (pro) renin receptor is a type I single transmembrane protein composed
唐欣颖，匡泽民，卢玺峰
doaj   +1 more source

Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats

, 2007
Recently, a (pro)renin receptor has been identified which mediates profibrotic effects independent of angiotensin II. Because antihypertensive therapy induces renal injury in the clipped kidney of two kidney-1-clip hypertensive rats, we examined the ...
Wenzel, U., Van den Berg - Garrelds, Ingrid; id_orcid, Stahl, R.A.K., Nguyen, G., Steinmetz, O.M., Krebs, C., Nguyen, G, Sadaghiani, S, Hamming, I, Hamming, I., Contrepas, A, van Goor, H., Krebs, C, Sadaghiani, S., Danser, A. H. J., Wenzel, U, Garrelds, I. M., Fehr, S., Contrepas, A., van Goor, H, Fehr, S, Danser, Jan, Meyer-Schwesinger, C., Steinmetz, MO, Stahl, R. A. K., Steinmetz, O. M., Meyer-Schwesinger, C, Stahl, RAK, Danser, A.H.J., Garrelds, I.M., van Goor, H.; id_orcid   +30 more
core   +1 more source

The (pro)renin receptor. A decade of research: What have we learned? [PDF]

, 2013
The discovery of a (pro)renin receptor ((P)RR) in 2002 provided a long-sought explanation for tissue renin-angiotensin system (RAS) activity and a function for circulating prorenin, the inactive precursor of renin, in end-organ damage.
Lu, X. (Xifeng), Krop, M. (Manne), Meima, M.E. (Marcel), Krop, Manne, Meima, Marcel, Danser, A.H.J. (Jan), Lu, XF, Danser, Jan   +7 more
core   +1 more source

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science, EarlyView.
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
wiley   +1 more source

(Pro)renin Receptor in Kidney Development and Disease

International Journal of Nephrology, 2011
The renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. All the components of the RAS are expressed in the developing metanephros.
Renfang Song, Ihor V. Yosypiv
doaj   +1 more source

Superimposing a high-fat diet on Schistosoma mansoni infection affects renin-angiotensin system components in the mouse kidney

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: The levels of the full-length form of the (pro)renin receptor (PRR), a component of the renin-angiotensin system (RAS), may be reduced in the membranes of kidneys in renal diseases.
Danielle Guedes Dantas Lira, Danielly Cantarelli de Oliveira, Fábio André Brayner, André de Lima Aires, Mônica Camelo Pessoa A. Albuquerque, Leucio Duarte Vieira, Célia Maria Machado Barbosa de Castro, Ana Durce Paixão   +7 more
doaj   +1 more source

Physiology of the (pro)renin receptor: Wnt of change?

, 2010
The (pro)renin receptor is a protein that binds prorenin and renin in tissues, leading to their activation and, at the same time, to the initiation of intracellular signaling.
Rousselle, Anthony, Bader, Michael, Burckle, C., Burckle, Celine, Sihn, Gabin, Vilianovitch, Larissa, Vilianovitch, L., Sihn, G., Bader, M., Rousselle, A.   +9 more
core   +1 more source