Results 71 to 80 of about 2,679,159 (249)

Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats. [PDF]

PLoS ONE, 2017
A high salt intake causes hypertension and leads to cardiovascular disease. Therefore, a low salt diet is now recommended to prevent hypertension and cardiovascular disease.
Chihiro Okamoto, Yuka Hayakawa, Takuma Aoyama, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Hiromitsu Kanamori, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Shinya Minatoguchi   +11 more
doaj   +1 more source

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?

International Journal of Hypertension, 2012
It is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release. However, how the brain synthesizes angiotensin (Ang)
Wencheng Li, Hua Peng, Dale M. Seth, Yumei Feng   +3 more
doaj   +1 more source

The Putative (Pro)renin Receptor Blocker HRP Fails to Prevent (Pro)renin Signaling [PDF]

Journal of the American Society of Nephrology, 2008
The prorenin/renin receptor is a recently discovered component of the renin-angiotensin system. The effects of aliskiren, a direct inhibitor of human renin, were compared with the handle region decoy peptide (HRP), which blocks the prorenin/renin receptor, in double-transgenic rats overexpressing the human renin and angiotensinogen genes.
Sandra, Feldt, Ulrike, Maschke, Ralf, Dechend, Friedrich C, Luft, Dominik N, Muller   +4 more
openaire   +2 more sources

Pro-renin receptor (PRR) expression in mouse renal mesangial cells.

, 2019
(A) Pro-renin receptor (PRR) mRNA and (B) protein expression in normal glucose (NG, 25 mmol L-glucose) and high glucose (HG, 25 mmol D-glucose) cultured mRMCs treated with either scramble (Scr) siRNA or PRR siRNA. Western blot analysis of pAMPK and total
Helmy M. Siragy (8082086), Safia Akhtar (8082083)   +1 more
core   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

(Pro)renin and its receptors: Pathophysiological implications

, 2012
Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin [together denoted as (pro)renin].
Batenburg, Wendy, Danser, A.H.J. (Jan), Batenburg, W.W. (Wendy), Danser, Jan   +3 more
core   +1 more source

Temporal Trends and Prognosis in Rotational Atherectomy: A Comparison of Contemporary and Traditional Eras

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Rotational atherectomy (RA) has undergone considerable technical modernization in recent years. This study evaluated whether RA performed in the contemporary era was associated with superior cardiovascular outcomes compared with the traditional era. Aims To compare the clinical characteristics and cardiovascular outcomes of patients
Ravi Vazirani, Gonzalo García‐Martí, Andrés Provencio‐Regidor, Irene Serrano‐García, Adrián Jerónimo‐Baza, Alejandro Travieso, Gabriela Tirado‐Conte, Fernando Macaya‐Ten, Hernán Mejía‐Rentería, Pablo Salinas, Luis Nombela‐Franco, Pilar Jiménez‐Quevedo, Nieves Gonzalo, Javier Escaned, Antonio Fernández‐Ortiz, Iván J. Núñez‐Gil   +15 more
wiley   +1 more source

Expression of cardiac tissue prorenin, renin, (pro)renin receptor, angiotensinogen and angiotensin II AT1 receptor.

, 2015
Expressions of cardiac tissue (a) prorenin, (b) renin, (c) (pro)renin receptor, (d) angiotensinogen and (e) angiotensin AT1 receptor in the WKY + normal-salt group (WKY+NS), WKY + high-salt group (WKY+HS), SHR + normal-salt group (SHR+NS) and SHR + high ...
Takuma Aoyama (675581), Shingo Minatoguchi (709054), Fumiaki Suzuki (709059), Masamitsu Iwasa (709055), Chiharu Yokoyama (675582), Atsushi Mikami (709058), Itta Kawamura (709057), Hisaaki Komaki (709053), Shinya Minatoguchi (675586), Yuka Hayakawa (675583), Masanori Kawasaki (274320), Yoshihisa Yamada (709056), Chihiro Okamoto (709052), Kazuhiko Nishigaki (675585)   +13 more
core   +1 more source

Furosemide stimulates renin expression in the kidneys of salt-supplemented rats [PDF]

, 1993
This study was conducted to obtain information about a possible influence of salt transport by the thick ascending limb of Henle (TALH) and the macula densa on the expression of renin in the kidney.
Eckardt, K. U., Kurtz, Armin, Kaissling, B., Modena, B., Riegger, G., Holmer, S., Schricker, K.   +6 more
core   +1 more source