Results 51 to 60 of about 142,423 (312)
Frontiers in Physiology, 2021 Diabetic cardiomyopathy (DCM) is a common complication associated with diabetes. The (pro)renin receptor (PRR) is an important member of the local tissue renin-angiotensin system and plays a vital role in many cardiovascular diseases.
J. Xiong +7 more
semanticscholar +1 more source
Regulation of the (pro)renin–renin receptor in cardiac remodelling [PDF]
Journal of Cellular and Molecular Medicine, 2012 AbstractThe (pro)renin–renin receptor [(P)RR] was discovered as an important novel component of the renin–angiotensin system (RAS). The functional significance of (P)RR is widely studied in renal and vascular pathologies and has sparked interest for a potential role in cardiovascular disease. To investigate the role of (P)RR in cardiac pathophysiology,
Mahmud, Hasan +4 more
openaire +3 more sources
Scientific Reports, 2021 (Pro)renin receptor (PRR) and Yes-associated protein (YAP) play an important role in cardiovascular diseases. However, the role of PRR–YAP pathway in the pathogenesis of DCM is also not clear. We hypothesized that PRR–YAP pathway may promote pathological
Shiran Yu +7 more
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2010 Since renin inhibition interferes with the first and rate-limiting steps in the renin–angiotensin system, the renin step is a very attractive target for lowering blood pressure and minimizing target-organ damage.
Atsuhiro Ichihara +6 more
doaj +1 more source
Treatment combining aliskiren with paricalcitol is effective against progressive renal tubulointerstitial fibrosis via dual blockade of intrarenal renin. [PDF]
PLoS ONE, 2017 The aim of this study was to assess any potential additive effects of a treatment combining aliskiren with paricalcitol on reducing renal fibrosis. C57BL/6J mice were treated individually with aliskiren and/or paricalcitol until 7 days after initiation ...
Sungjin Chung +7 more
doaj +1 more source
The Soluble (Pro)Renin Receptor in Health and Diseases: Foe or Friend?
Journal of Pharmacology and Experimental Therapeutics, 2021 The (pro)renin receptor (PRR) is a single-transmembrane protein that regulates the local renin-angiotensin system and participates in various intracellular signaling pathways, thus exhibiting a significant physiopathologic relevance in cellular ...
Manman Qin, Chuanming Xu, Jun Yu
semanticscholar +1 more source
The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers
Cell Communication and Signaling, 2020 The (pro) renin receptor ((P)RR) plays important roles in various pathways, such as the Wnt/β-catenin, renin-angiotensin system (RAS), MAPK/ERK and PI3K/AKT/mTOR pathways, that are involved in a wide range of physiological and pathological processes ...
Juan Wang +4 more
semanticscholar +1 more source
Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury [PDF]
, 2015 香川大学Kagawa University博士（医学）Abstract The purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg.
請川, 香里 +2 more
core +1 more source
Inhibition of renin and the (pro)renin receptor system
Blood Pressure, 2012 Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT(1)R) axis.
Cuie, Guang +3 more
openaire +2 more sources
Expression of renin–angiotensin system (RAS) components in endometrial cancer
Endocrine Connections, 2017 A dysfunctional endometrial renin–angiotensin system (RAS) could aid the growth and spread of endometrial cancer. To determine if the RAS is altered in endometrial cancer, we measured RAS gene expression and protein levels in 30 human formalin-fixed ...
Sarah J Delforce +9 more
doaj +1 more source