Results 31 to 40 of about 142,423 (312)
Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours [PDF]
Diagnostics, 2021 (1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour progression.
Jon Danel Solano-Iturri +7 more
doaj +2 more sources
PLoS ONE, 2018 Antithyroid drugs are generally selected as the first-line treatment for Graves' Disease (GD); however, the existence of patients showing resistance or severe side effects to these drugs is an important issue to be solved. The (pro)renin receptor [(P)RR]
Yuki Mizuguchi +11 more
doaj +2 more sources
The biology of the (pro)renin receptor [PDF]
Journal of the American Society of Nephrology, 2009 The (pro)renin receptor (PRR) binds renin and prorenin, its proenzyme inactive form. Receptor-bound prorenin becomes enzymatically active and binding then activates the MAP kinases ERK1/2 and p38 pathways, leading to upregulation of profibrotic and ...
Nguyen, G. +3 more
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Molecular Therapy: Nucleic Acids, 2019 The receptor-associated prorenin system refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent signaling, and its activation contributes to
Ye Liu +7 more
doaj +2 more sources
Hypertension, 2008 The aim of this study was to explore the effects of the renin inhibitor aliskiren in streptozotocin-diabetic TG(mRen-2)27 rats. Furthermore, we investigated in vitro the effect of aliskiren on the interactions between renin and the (pro)renin receptor ...
David L Feldman +2 more
exaly +2 more sources
The (pro)renin receptor: A new addition to the renin-angiotensin system?
European Journal of Pharmacology, 2008 The renin-angiotensin system is still incompletely understood. In particular, the function of prorenin, the inactive precursor of renin, is unknown.
Batenburg, Wendy, Danser, Jan
core +4 more sources
(Pro)renin and (pro)renin receptor expression during kidney development in neonates [PDF]
European Journal of Pediatrics, 2016 Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood.
Kagami, Shoji +22 more
core +3 more sources
(Pro)renin receptor: subcellular localizations and functions
Frontiers in Bioscience, 2013 Since its first report in 1996, the concept of the so-called (Pro)renin receptor ((P)RR/ATP6ap2) has dramactically evolved from a receptor mediating cellular effects of (pro)renin, to a protein with more basic and potentially essential intracellular ...
Burckle, C. +4 more
core +3 more sources
Renin, Prorenin and the Putative (Pro)renin Receptor [PDF]
Hypertension, 2005 Renin is an aspartic protease that consists of 2 homologous lobes. The cleft in between contains the active site with 2 catalytic aspartic residues.1 Unlike other aspartic proteases such as pepsin or cathepsin D, renin is monospecific and only cleaves angiotensinogen, to generate angiotensin (Ang) I.
Danser, A.H., Deinum, J.
+8 more sources
The Putative (Pro)renin Receptor Blocker HRP Fails to Prevent (Pro)renin Signaling [PDF]
Journal of the American Society of Nephrology, 2008 The prorenin/renin receptor is a recently discovered component of the renin-angiotensin system. The effects of aliskiren, a direct inhibitor of human renin, were compared with the handle region decoy peptide (HRP), which blocks the prorenin/renin ...
Sandra Feldt +9 more
core +3 more sources