Results 31 to 40 of about 32,074 (246)
Endocrine Regulations, 2016 Adipose tissue expresses all the renin-angiotensin system (RAS) components that play an important role in the adipogenesis, lipid and glucose metabolism regulation in an auto/paracrine manner.
Slamkova M, Zorad S, Krskova K
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Role of Nonclassical Renin-angiotensin system Axis In Renal Fibrosis
Frontiers in Physiology, 2015 The renin–angiotensin system (RAS) is a major regulator of renal fibrosis. Besides the classical renin/Angiotensin-converting enzyme 2 (ACE2)/angiotensin II (Ang II)/AT1 and AT2 axis, multiple new axes have been recently described.
Linli eLv, Bi-Cheng eLiu
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Is (Pro)Renin Receptor a Multifunctional Receptor? [PDF]
Hypertension, 2010 The existence of various components of the renin-angiotensin system in the eye has been known for more than a decade, and the importance of this system in ocular pathophysiology is a subject of active investigation.1 It has long been recognized that prorenin, an inactive precursor of renin, is elevated in the ocular fluids of patients with diabetic ...
Qiuhong Li, Mohan K. Raizada
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BMC Nephrology, 2012 Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Fernandez-Fernandez Beatriz +5 more
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Renin and the IGFII/M6P Receptor System in Cardiac Biology
The Scientific World Journal, 2013 Nonenzymatic cardiac activities of renin are well described during the last years and contribute either to cardiac-specific effects of the renin-angiotensin-aldosterone-system (RAAS) or to the pharmacological effects of RAAS inhibition.
Jacqueline Heger, Klaus-Dieter Schlüter
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Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours
Diagnostics, 2021 (1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour progression.
Jon Danel Solano-Iturri +7 more
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Novel Antihypertensive Medications to Target the Renin-Angiotensin System: Mechanisms and Research
Reviews in Cardiovascular MedicineAn estimated 1.28 billion individuals in the global population suffer from hypertension. Importantly, uncontrolled hypertension is strongly linked to various cardiovascular and cerebrovascular diseases.
Zhe Jiang, Changlin Zhai, Guanmin Tang
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Roles of the (pro)renin receptor in the kidney
World Journal of Nephrology, 2014 Prorenin receptor (PRR) is a multi-functioning protein possessing at least four different roles: (1) working as a receptor for renin and prorenin producing angiotensin I from angiotensinogen thus enhancing the tissue renin-angiotensin system; (2) inducing intracellular signals when a ligand binds to PRR; (3) participating in the functions of vacuolar ...
Yoichi, Oshima +2 more
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Increased (Pro)renin Receptor Expression in the Hypertensive Human Brain
Frontiers in Physiology, 2020 Overactivation of the renin-angiotensin system (RAS) – a central physiological pathway involved in controlling blood pressure (BP) – leads to hypertension.
Minhazul Mohsin +15 more
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Advanced Science, EarlyView.An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu +10 more
wiley +1 more source