Results 31 to 40 of about 2,679,159 (249)

Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats [PDF]

, 2007
Recently, a (pro)renin receptor has been identified which mediates profibrotic effects independent of angiotensin II. Because antihypertensive therapy induces renal injury in the clipped kidney of two kidney-1-clip hypertensive rats, we examined the ...
Wenzel, U., Van den Berg - Garrelds, Ingrid; id_orcid, Stahl, R.A.K., Nguyen, G., Steinmetz, O.M., Krebs, C., Nguyen, G, Sadaghiani, S, Hamming, I, Hamming, I., Contrepas, A, van Goor, H., Krebs, C, Sadaghiani, S., Danser, A. H. J., Wenzel, U, Garrelds, I. M., Fehr, S., Contrepas, A., van Goor, H, Fehr, S, Danser, Jan, Meyer-Schwesinger, C., Steinmetz, MO, Stahl, R. A. K., Steinmetz, O. M., Meyer-Schwesinger, C, Stahl, RAK, Danser, A.H.J., Garrelds, I.M., van Goor, H.; id_orcid   +30 more
core   +1 more source

Renin and the IGFII/M6P Receptor System in Cardiac Biology

The Scientific World Journal, 2013
Nonenzymatic cardiac activities of renin are well described during the last years and contribute either to cardiac-specific effects of the renin-angiotensin-aldosterone-system (RAAS) or to the pharmacological effects of RAAS inhibition.
Jacqueline Heger, Klaus-Dieter Schlüter
doaj   +1 more source

Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis?

BMC Nephrology, 2012
Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Fernandez-Fernandez Beatriz, Ortiz Alberto, Gomez-Guerrero Carmen, Barat Antonio, Martín-Cleary Catalina, Egido Jesús   +5 more
doaj   +1 more source

Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours

Diagnostics, 2021
(1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour progression.
Jon Danel Solano-Iturri, Enrique Echevarría, Miguel Unda, Ana Loizaga-Iriarte, Amparo Pérez-Fernández, Javier C. Angulo, José I. López, Gorka Larrinaga   +7 more
doaj   +1 more source

Physiology of the (pro)renin receptor: Wnt of change? [PDF]

, 2010
The (pro)renin receptor is a protein that binds prorenin and renin in tissues, leading to their activation and, at the same time, to the initiation of intracellular signaling.
Rousselle, Anthony, Bader, Michael, Burckle, C., Burckle, Celine, Sihn, Gabin, Vilianovitch, Larissa, Vilianovitch, L., Sihn, G., Bader, M., Rousselle, A.   +9 more
core   +1 more source

Novel Antihypertensive Medications to Target the Renin-Angiotensin System: Mechanisms and Research

Reviews in Cardiovascular Medicine
An estimated 1.28 billion individuals in the global population suffer from hypertension. Importantly, uncontrolled hypertension is strongly linked to various cardiovascular and cerebrovascular diseases.
Zhe Jiang, Changlin Zhai, Guanmin Tang
doaj   +1 more source

Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans.

PLoS ONE, 2021
The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8-9, a residual hydrophobic truncated protein.
Nobukazu Sasaki, Satoshi Morimoto, Chikahito Suda, Satoru Shimizu, Atsuhiro Ichihara   +4 more
doaj   +1 more source

Roles of the (pro)renin receptor in the kidney

World Journal of Nephrology, 2014
Prorenin receptor (PRR) is a multi-functioning protein possessing at least four different roles: (1) working as a receptor for renin and prorenin producing angiotensin I from angiotensinogen thus enhancing the tissue renin-angiotensin system; (2) inducing intracellular signals when a ligand binds to PRR; (3) participating in the functions of vacuolar ...
Yoichi, Oshima, Satoshi, Morimoto, Atsuhiro, Ichihara   +2 more
openaire   +2 more sources

Increased (Pro)renin Receptor Expression in the Hypertensive Human Brain

Frontiers in Physiology, 2020
Overactivation of the renin-angiotensin system (RAS) – a central physiological pathway involved in controlling blood pressure (BP) – leads to hypertension.
Minhazul Mohsin, Minhazul Mohsin, Lucas A. C. Souza, Lucas A. C. Souza, Simindokht Aliabadi, Simindokht Aliabadi, Caleb J. Worker, Caleb J. Worker, Silvana G. Cooper, Silvana G. Cooper, Sanzida Afrin, Sanzida Afrin, Yuki Murata, Zhenggang Xiong, Yumei Feng Earley, Yumei Feng Earley   +15 more
doaj   +1 more source

Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury [PDF]

, 2015
香川大学Kagawa University博士（医学）Abstract The purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg.
請川, 香里, ウケガワ, カオリ, Ukegawa, Kaori   +2 more
core   +1 more source