Results 11 to 20 of about 32,074 (246)
The Pathological Role of Pro(Renin) Receptor in Renal Inflammation [PDF]
Journal of Experimental Pharmacology, 2021 Syed S Quadri,1 Caleb Cooper,2 Dawood Ghaffar,1 Hitesh Vaishnav,1 Ludmila Nahar3 1DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Knoxville, TN, USA; 2DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN,
Quadri SS +4 more
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Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans. [PDF]
PLoS ONE, 2021 The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8-9, a residual hydrophobic truncated protein.
Nobukazu Sasaki +4 more
doaj +2 more sources
Inhibition of (Pro)renin Receptor-Mediated Oxidative Stress Alleviates Doxorubicin-Induced Heart Failure [PDF]
Frontiers in Oncology, 2022 AimClinical utility of doxorubicin (DOX) is limited by its cardiotoxic side effect, and the underlying mechanism still needs to be fully elucidated. This research aimed to examine the role of (pro)renin receptor (PRR) in DOX-induced heart failure (HF ...
Xiao-yi Du +5 more
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Soluble (Pro)Renin Receptor in Hypertension. [PDF]
Nephron, 2023 The (pro)renin receptor (PRR) was originally cloned as a specific single-transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physiopathological processes.
Yang T.
europepmc +3 more sources
Soluble (pro)renin receptor as a novel laboratory biomarker of atherosclerosis [PDF]
Acta Biochimica et Biophysica SinicaLiu Chunju +10 more
doaj +2 more sources
Renin, Prorenin and the Putative (Pro)renin Receptor [PDF]
Hypertension, 2005 Renin is an aspartic protease that consists of 2 homologous lobes. The cleft in between contains the active site with 2 catalytic aspartic residues.1 Unlike other aspartic proteases such as pepsin or cathepsin D, renin is monospecific and only cleaves angiotensinogen, to generate angiotensin (Ang) I.
Danser, A.H., Deinum, J.
+8 more sources
Antioxidants, 2021 Dysregulation of the tissue renin–angiotensin system (RAS) is involved in tissue oxidative and inflammatory responses. Among RAS components, renin, its precursor (pro)renin and its specific receptor (PRR) have been less investigated, particularly in the ...
Andrea Lopez-Lopez +7 more
doaj +1 more source
Elevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia [PDF]
American Journal of Hypertension, 2015 Preeclampsia (preE), a syndrome of hypertension, proteinuria, and edema, has many elusive triggers. The renin-angiotensin system has been implicated in preE pathogenesis. In this study, we test the hypothesis that (pro)renin levels are increased in preE patients and that levels of (pro)renin and (pro)renin receptor ((P)RR) are elevated in a rat model ...
Jessica, Thomason +7 more
openaire +2 more sources
The Biology of the (Pro)Renin Receptor [PDF]
Journal of the American Society of Nephrology, 2010 The (pro)renin receptor (PRR) binds renin and prorenin, its proenzyme inactive form. Receptor-bound prorenin becomes enzymatically active and binding then activates the MAP kinases ERK1/2 and p38 pathways, leading to upregulation of profibrotic and cyclooxygenase-2 genes independent of angiotensin II generation.
Genevieve, Nguyen, Dominik N, Muller
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Ontogeny of the (pro)renin receptor [PDF]
Pediatric Research, 2013 This study examined temporal expression of the (pro)renin receptor ((P)RR), during renal, heart, lung, and brain organogenesis in the mouse.(P)RR expression was determined by quantitative reverse-transcription PCR, western blotting, and immunohistochemistry.Brain, kidney, and lung (P)RR mRNA levels increased progressively during gestation and peak on ...
Renfang, Song +2 more
openaire +2 more sources