Autophagy and the (pro)renin receptor [PDF]
Frontiers in Endocrinology, 2013 The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure.
Katrina Jean Binger, Dominik N Muller
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Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts [PDF]
Scientific Reports, 2021 The (pro)renin receptor (PRR) is a multifunctional integral membrane protein that serves as a component of the vacuolar H+-ATPase (V-ATPase) and also activates (pro)renin.
Jonathan B. Murray +5 more
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Adrenal (Pro)renin Receptor Expression and Serum Soluble (Pro)renin Receptor Concentration in Primary Aldosteronism [PDF]
International Journal of Endocrinology, 2020 The (pro)renin receptor [(P)RR] is a multifunctioning protein playing roles in various pathological conditions. A soluble form of (P)RR [s(P)RR] has been considered a biomarker for (P)RR expression in tissues.
Daisuke Watanabe +6 more
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Aliskiren-Loaded Nanoparticles Downregulate (Pro)renin Receptor and ACE Gene Expression in the Heart of Spontaneously Hypertensive Rats: Effect on NADPH Oxidase. [PDF]
Int J Mol SciWe aimed to determine effects of aliskiren, a direct renin inhibitor, loaded onto polymeric nanoparticles on the (pro)renin receptor (Atp6ap2), angiotensin II type 1 receptor (Agtr1), and angiotensin-converting enzyme (ACE) gene expression in the heart ...
Barta A +5 more
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Revisiting the relationship between (Pro)Renin receptor and the intrarenal RAS: focus on the soluble receptor. [PDF]
Curr Opin Nephrol Hypertens, 2022 Purpose of review The (pro)renin receptor (PRR), also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2), was originally cloned as a specific receptor for prorenin and renin [together called (pro)renin].
Yang T.
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Role of (pro)renin receptor in cyclosporin A-induced nephropathy.
Am J Physiol Renal Physiol, 2022 Calcineurin inhibitors (CNIs) such as cyclosporin A (CsA) have been widely used to improve graft survival following solid-organ transplantation. However, the clinical use of CsA is often limited by its nephrotoxicity.
Hu J +10 more
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Potential of soluble (pro)renin receptor in kidney disease: can it go beyond a biomarker?
Am J Physiol Renal Physiol, 2022 (Pro)renin receptor (PRR) also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2) belongs to type I transmembrane receptor and is capable of binding and activating prorenin and renin.
Yang T.
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Inhibitory effect of (pro)renin receptor decoy inhibitor PRO20 on endoplasmic reticulum stress during cardiac remodeling. [PDF]
Front Pharmacol, 2022 Background: Ectopic activation of renin-angiotensin-system contributes to cardiovascular and renal diseases. (Pro)renin receptor (PRR) binds to renin and prorenin, participating in the progression of nephrology.
Zhang J, Cheng YJ, Luo CJ, Yu J.
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Regulation of (Pro)Renin Receptor in Renin-Positive Smooth Muscle Cells of Kidney Arterioles in Rats with STZ-Induced Diabetes [PDF]
International Journal of Nephrology, 2019 Objective. The nephron (pro)renin receptor may play a pathophysiological role in renal disorders in hypertension or diabetes. The aim of this study was to determine the relationship of (pro)renin receptors and transdifferentiation between the renin ...
Zsolt Razga +4 more
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(Pro)renin Receptor and Blood Pressure Regulation: A Focus on the Central Nervous System. [PDF]
Curr Hypertens Rev, 2022 The renin-angiotensin system (RAS) is classically described as a hormonal system in which angiotensin II (Ang II) is one of the main active peptides.
Souza LAC, Earley YF.
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