Results 21 to 30 of about 142,423 (312)
The relationship between kidney function and the soluble (pro)renin receptor in young adults: the African-PREDICT study [PDF]
BMC NephrologyHigh renin angiotensin-aldosterone system (RAAS) activity is associated with target organ damage. Soluble (pro)renin receptor [s(P)RR] forms part of the RAAS cascade and is associated with kidney damage through both angiotensin II-dependent and ...
Phuti J. Mokgonyana +3 more
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Inhibition of (Pro)renin Receptor-Mediated Oxidative Stress Alleviates Doxorubicin-Induced Heart Failure. [PDF]
Front Oncol, 2022 Aim Clinical utility of doxorubicin (DOX) is limited by its cardiotoxic side effect, and the underlying mechanism still needs to be fully elucidated. This research aimed to examine the role of (pro)renin receptor (PRR) in DOX-induced heart failure (HF ...
Du XY, Xiang DC, Gao P, Peng H, Liu YL.
europepmc +2 more sources
Mutagenesis of the Cleavage Site of Pro Renin Receptor Abrogates Angiotensin II-Induced Hypertension in Mice. [PDF]
Hypertension, 2021 Supplemental Digital Content is available in the text. It is well demonstrated that activation of renal PRR ([pro]renin receptor) contributes to AngII (angiotensin II)-induced hypertension. Relatively, less is known for the function of sPRR (soluble PRR),
Wang F, Chen Y, Zou CJ, Luo R, Yang T.
europepmc +2 more sources
Physiological Reports, 2021 Introduction (Pro)renin receptor has emerged as a new member of the renin‐angiotensin system implicated in the pathogenesis of chronic kidney disease (CKD).
Yan Wang +8 more
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Am J Physiol Renal Physiol, 2023 Soluble (pro)renin receptor (sPRR), the extracellular domain of (pro)renin receptor (PRR), is primarily generated by site-1 protease (S1P) and furin. It has been reported that sPRR functions as an important regulator of intrarenal renin contributing to ...
Fu Z +6 more
europepmc +2 more sources
Assessment of the (Pro)renin Receptor Protein Expression in Organs [PDF]
Current Issues in Molecular BiologyThe (pro)renin receptor ((P)RR) is an essential component of the renin–angiotensin system (RAS) as a specific single-pass transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of ...
Teng-Yao Yang +4 more
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Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (Na+-Cl- Cotransporter) Activity. [PDF]
Hypertension, 2021 Supplemental Digital Content is available in the text. NCC (Na+-Cl− cotransporter), uniquely located at the distal convoluted tubule (DCT), is the target of thiazide diuretics and critically involved in renal handling of both Na+ and K+.
Xu C, Chen Y, Wang F, Xie S, Yang T.
europepmc +2 more sources
The Pathological Role of Pro(Renin) Receptor in Renal Inflammation [PDF]
Journal of Experimental Pharmacology, 2021 Syed S Quadri,1 Caleb Cooper,2 Dawood Ghaffar,1 Hitesh Vaishnav,1 Ludmila Nahar3 1DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Knoxville, TN, USA; 2DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN,
Quadri SS +4 more
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Renin, (pro)renin and receptor: an update
Clinical Science, 2010 PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving ERK (extracellular-signal-regulated kinase) 1/2.
Genevieve Nguyen
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Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans. [PDF]
PLoS ONE, 2021 The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8-9, a residual hydrophobic truncated protein.
Nobukazu Sasaki +4 more
doaj +2 more sources