Results 1 to 10 of about 9,486 (117)

Soluble (Pro)Renin Receptor Levels Are Regulated by Plasma Renin Activity and Correlated with Edema in Mice and Humans with HFrEF [PDF]

Biomedicines, 2022
Symptomatic heart failure with reduced ejection fraction (HFrEF) is characterized by edema and chronic pathological activation of the classical renin–angiotensin–aldosterone system (RAAS). The soluble (pro)renin receptor (s(P)RR) is released into circulation by proteolytic cleavage of tissue expressed (P)RR and is a candidate biomarker of RAAS ...
Inna P Gladysheva, R Sullivan, Guy L Reed   +2 more
exaly   +5 more sources

Soluble (Pro)Renin Receptor in Hypertension. [PDF]

Nephron, 2023
The (pro)renin receptor (PRR) was originally cloned as a specific single-transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physiopathological processes.
Yang T.
europepmc   +3 more sources

Adrenal (Pro)renin Receptor Expression and Serum Soluble (Pro)renin Receptor Concentration in Primary Aldosteronism. [PDF]

Int J Endocrinol, 2020
The (pro)renin receptor [(P)RR] is a multifunctioning protein playing roles in various pathological conditions. A soluble form of (P)RR [s(P)RR] has been considered a biomarker for (P)RR expression in tissues. Expression of (P)RR has been described in aldosterone-producing adenoma (APA), but the roles of (P)RR have yet to be fully determined.
Watanabe D, Morimoto S, Morishima N, Kato Y, Nagashima Y, Shibata N, Ichihara A.   +6 more
europepmc   +4 more sources

Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans. [PDF]

PLoS One, 2021
The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8–9, a residual hydrophobic truncated protein. The (pro)renin receptor also functions as an intracellular accessory protein of vacuolar-type H+-ATPase, which plays an essential role in ...
Sasaki N, Morimoto S, Suda C, Shimizu S, Ichihara A.   +4 more
europepmc   +5 more sources

Relationship between Soluble (pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure. [PDF]

J Clin Med, 2020
The (pro)renin receptor ((P)RR), which evokes renin activity with prorenin, is secreted extracellularly as soluble (P)RR (s(P)RR) and may participate in tissue renin-angiotensin system (RAS) activity in severe heart failure (HF) patients. The aim of this study was to determine whether s(P)RR is an adequate marker in severe HF patients treated with RAS ...
Ikeda Y, Tsutsui K, Yamada Y, Kato R, Muramatsu T, Senbonmatsu T.   +5 more
europepmc   +4 more sources

Soluble (pro)renin receptor as a potential therapy for diabetes insipidus. [PDF]

Am J Physiol Renal Physiol, 2018
The antidiuretic hormone vasopressin (VP) is produced by the hypothalamus and is stored and secreted from the posterior pituitary. VP acts via VP type 2 receptors (V2Rs) on the basolateral membrane of principal cells of the collecting duct (CD) to regulate fluid permeability.
Yang KT, Yang T, Symons JD.
europepmc   +3 more sources

Plasma Soluble (Pro)renin Receptor Reflects Renal Damage. [PDF]

PLoS One, 2016
(Pro)renin receptor [(P)RR], a specific receptor for renin and prorenin, was identified as a member of the renin-angiotensin system (RAS). (P)RR is cleaved by furin, and soluble (P)RR [s(P)RR] is secreted into the extracellular space. Previous reports have indicated that plasma s(P)RR levels show a significant positive relationship with urinary protein
Ohashi N, Isobe S, Ishigaki S, Suzuki T, Iwakura T, Ono M, Fujikura T, Tsuji T, Otsuka A, Ishii Y, Furuse H, Kato A, Ozono S, Yasuda H.   +13 more
europepmc   +5 more sources

Enzymatic sources and physio-pathological functions of soluble (pro)renin receptor. [PDF]

Curr Opin Nephrol Hypertens, 2018
(Pro)renin receptor (PRR) belongs to type I transmembrane receptor family and binds both prorenin and renin, representing a potential regulator of the activity of the renin-angiotensin system. Soluble form of PRR (sPRR) is generated by intracellular protease-mediated cleavage of full-length PRR.
Zhu Q, Yang T.
europepmc   +4 more sources

Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients. [PDF]

PLoS One, 2016
The (pro)renin receptor [(P)RR] is cleaved by furin to generate soluble (P)RR [s(P)RR], which reflects the status of the tissue renin-angiotensin system. Hemodialysis patients have advanced atherosclerosis. The aim of this study was to investigate the relationships between serum s(P)RR levels and background factors, including indices of atherosclerosis,
Amari Y, Morimoto S, Nakajima F, Ando T, Ichihara A.   +4 more
europepmc   +5 more sources

Serum soluble (pro)renin receptor levels in patients with essential hypertension. [PDF]

Hypertens Res, 2014
The (pro)renin receptor ((P)RR) is expressed in several tissues including kidney, heart and brain, and is thought to regulate the tissue renin-angiotensin system (RAS) through the non-proteolytic activation of prorenin. (P)RR is cleaved by furin to generate soluble (P)RR (s(P)RR), which is secreted into the extracellular space.
Morimoto S, Ando T, Niiyama M, Seki Y, Yoshida N, Watanabe D, Kawakami-Mori F, Kobori H, Nishiyama A, Ichihara A.   +9 more
europepmc   +4 more sources