Results 1 to 10 of about 9,553 (133)

Soluble (Pro)Renin Receptor Levels Are Regulated by Plasma Renin Activity and Correlated with Edema in Mice and Humans with HFrEF [PDF]

Biomedicines, 2022
Symptomatic heart failure with reduced ejection fraction (HFrEF) is characterized by edema and chronic pathological activation of the classical renin–angiotensin–aldosterone system (RAAS).
Inna P. Gladysheva, Ryan D. Sullivan, Kodangudi Ramanathan, Guy L. Reed   +3 more
doaj   +6 more sources

Adrenal (Pro)renin Receptor Expression and Serum Soluble (Pro)renin Receptor Concentration in Primary Aldosteronism [PDF]

International Journal of Endocrinology, 2020
The (pro)renin receptor [(P)RR] is a multifunctioning protein playing roles in various pathological conditions. A soluble form of (P)RR [s(P)RR] has been considered a biomarker for (P)RR expression in tissues.
Daisuke Watanabe, Satoshi Morimoto, Noriko Morishima, Yoichiro Kato, Yoji Nagashima, Noriyuki Shibata, Atsuhiro Ichihara   +6 more
doaj   +4 more sources

Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans. [PDF]

PLoS ONE, 2021
The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8-9, a residual hydrophobic truncated protein.
Nobukazu Sasaki, Satoshi Morimoto, Chikahito Suda, Satoru Shimizu, Atsuhiro Ichihara   +4 more
doaj   +4 more sources

Plasma Soluble (Pro)renin Receptor Reflects Renal Damage. [PDF]

PLoS ONE, 2016
Background(Pro)renin receptor [(P)RR], a specific receptor for renin and prorenin, was identified as a member of the renin-angiotensin system (RAS). (P)RR is cleaved by furin, and soluble (P)RR [s(P)RR] is secreted into the extracellular space.
Naro Ohashi, Shinsuke Isobe, Sayaka Ishigaki, Takahisa Suzuki, Takamasa Iwakura, Masafumi Ono, Tomoyuki Fujikura, Takayuki Tsuji, Atsushi Otsuka, Yasuo Ishii, Hiroshi Furuse, Akihiko Kato, Seiichiro Ozono, Hideo Yasuda   +13 more
doaj   +5 more sources

Soluble (Pro)renin Receptor Is Adversely Associated with Indices of Left Ventricular Structure and Function: The African-PREDICT Study [PDF]

Journal of Cardiovascular Development and Disease, 2022
This study aims to compare soluble (pro)renin receptor [s(P)RR] levels between black and white adults and to explore the associations of left ventricular (LV) structure and function with s(P)RR in the total and ethnicity-stratified groups.
Lebo F. Gafane-Matemane, Ruan Kruger, Johannes M. Van Rooyen, Philimon N. Gona, Aletta E. Schutte   +4 more
doaj   +2 more sources

Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis [PDF]

Scientific Reports, 2021
The (pro)renin receptor [(P)RR)] is a multifunctional protein that is cleaved to generate the soluble (P)RR [s(P)RR], reflecting the status of the tissue renin-angiotensin system and/or activity of the (P)RR.
Yoshifumi Amari, Satoshi Morimoto, Chikahito Suda, Takeshi Iida, Hidenobu Okuda, Takatomi Yurugi, Yasuo Oyama, Naoki Aoyama, Fumitaka Nakajima, Atsuhiro Ichihara   +9 more
doaj   +3 more sources

Soluble (pro)renin receptor level in patients with severe obesity is associated with visceral adiposity and is involved with insulin resistance and renal injury [PDF]

Obesity Facts, 2023
Introduction: High soluble (pro)renin receptor (s(P)RR) level in circulation is reported in obese patients; however, it is unclear which body composition components are responsible for it.
Takashi Yamaguchi, Satoshi Morimoto, Chikahito Suda, Atsuhiro Ichihara, Noriko Ishihara, Shoko Nakamura, Sho Tanaka, Yasuhiro Watanabe, Haruki Imamura, Masahiro Ohira, Naomi Shimizu, Atsuhito Saiki, Ichiro Tatsuno   +12 more
doaj   +2 more sources

The relationship between kidney function and the soluble (pro)renin receptor in young adults: the African-PREDICT study [PDF]

BMC Nephrology
High renin angiotensin-aldosterone system (RAAS) activity is associated with target organ damage. Soluble (pro)renin receptor [s(P)RR] forms part of the RAAS cascade and is associated with kidney damage through both angiotensin II-dependent and ...
Phuti J. Mokgonyana, Gontse G. Mokwatsi, Stella M. Gwini, Lebo F. Gafane-Matemane   +3 more
doaj   +2 more sources

Prediction of response to medical therapy by serum soluble (pro)renin receptor levels in Graves' disease. [PDF]

PLoS ONE, 2018
Antithyroid drugs are generally selected as the first-line treatment for Graves' Disease (GD); however, the existence of patients showing resistance or severe side effects to these drugs is an important issue to be solved. The (pro)renin receptor [(P)RR]
Yuki Mizuguchi, Satoshi Morimoto, Shihori Kimura, Noriyoshi Takano, Kaoru Yamashita, Yasufumi Seki, Kanako Bokuda, Midori Yatabe, Junichi Yatabe, Daisuke Watanabe, Takashi Ando, Atsuhiro Ichihara   +11 more
doaj   +2 more sources

Association between serum soluble (pro)renin receptor level and worsening of cardiac function in hemodialysis patients: A prospective observational study. [PDF]

PLoS ONE, 2020
The (pro)renin receptor ((P)RR) is cleaved to generate soluble (P)RR (s(P)RR), which reflects the status of the tissue renin-angiotensin system. Hemodialysis (HD) patients have a poor prognosis due to the increased prevalence of cardiovascular diseases ...
Yoshifumi Amari, Satoshi Morimoto, Takeshi Iida, Hiroki Takimoto, Hidenobu Okuda, Takatomi Yurugi, Yasuo Oyama, Naoki Aoyama, Fumitaka Nakajima, Atsuhiro Ichihara   +9 more
doaj   +2 more sources