Results 31 to 40 of about 9,553 (133)
American Journal of Physiology - Cell Physiology, 2017 Chuanming Xu, Hui Fang, Tianxin Yang
exaly +2 more sources
COVID-19 and Preeclampsia: Overlapping Features in Pregnancy
Rambam Maimonides Medical Journal, 2022 Coronavirus disease 2019 (COVID-19) is a global respiratory disease with unique features that have placed all medical professionals in an alarming situation.
Jayanthi Rajendran, Saravanan Sumathi
doaj +1 more source
Soluble (pro)renin receptor increased by hypoxia maintains oxidative metabolism in trophoblasts [PDF]
Journal of Molecular Endocrinology, 2020 Elevated soluble (pro)renin receptor (s(P)RR) concentration in maternal blood is associated with gestational hypertension and preeclampsia. Placenta has abundant expression of (P)RR, and the binding of (P)RR with pyruvate dehydrogenase E1 beta subunit (PDHB) is reported to maintain oxidative metabolism.
Chikahito, Suda +4 more
openaire +2 more sources
Molecules, 2023 Chronic kidney disease (CKD) is associated with advanced oxidation protein products (AOPPs). A recent study has shown that AOPP-induced renal tubular injury is mediated by the (pro)renin receptor (PRR).
Hui Fang +3 more
doaj +1 more source
Soluble (Pro)Renin Receptor and Blood Pressure During Pregnancy [PDF]
Hypertension, 2012 The renin–angiotensin system is believed to influence blood pressure (BP) during pregnancy, but the associations between BP during pregnancy and the soluble form of the (pro)renin receptor (s[P]RR), a new component of the tissue renin–angiotensin system, remain undetermined.
Noriyoshi, Watanabe +11 more
openaire +2 more sources
Molecular Therapy: Nucleic Acids, 2017 The receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to the (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling.
Atsuhiro Kanda +7 more
doaj +1 more source
The Tohoku Journal of Experimental Medicine, 2016 Water deprivation activates the renin-angiotensin system. We have hypothesized that the renal expression of (pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, could be changed under dehydration. Moreover, plasma levels of soluble (P)RR (s(P)RR) comprising of the extracellular domain of (P)RR may reflect the renal (P)RR expression.
Tamura, Yuma +9 more
openaire +3 more sources
The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers
Cell Communication and Signaling, 2020 Background The (pro) renin receptor ((P)RR) plays important roles in various pathways, such as the Wnt/β-catenin, renin-angiotensin system (RAS), MAPK/ERK and PI3K/AKT/mTOR pathways, that are involved in a wide range of physiological and pathological ...
Juan Wang +4 more
doaj +1 more source
Journal of Diabetes Investigation, 2019 The renin–angiotensin system (RAS), a crucial regulator of systemic blood pressure (circulatory RAS), plays distinct roles in pathological angiogenesis and inflammation in various organs (tissue RAS), such as diabetic microvascular complications.
Atsuhiro Kanda, Susumu Ishida
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source