Results 51 to 60 of about 9,609 (148)

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

A PILOT STUDY ON SOLUBLE (PRO)RENIN RECEPTOR IN SYSTEMIC SCLEROSIS

Romanian Journal of Rheumatology, 2015
Background. Wnt signaling is involved in fibrosis, but the mechanisms of cross-talk with other pathways, like TGF-β, are not fully understood. (Pro)renin receptor (PRR) functions as an accessory protein to a V-ATP-ase responsible for acidic pH maintenance in intracellular compartments, and recent data indicate that PRR could be a regulator of Wnt ...
Marilena Gorga, Alina-Mihaela Soare, Ana-Maria Gherghe, Rucsandra Dobrota, Cristina Mambet, Carina Mihai   +5 more
openaire   +1 more source

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

Beta Blocker Toxicity at Therapeutic Doses: A Look Into Carvedilol Use in the Elderly

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Beta‐blocker toxicity does not occur only in overdose situations. In vulnerable populations such as children and the elderly, therapeutic doses may produce cumulative toxic effects similar to those seen in acute overdose. These patients require monitoring that extends beyond basic laboratory investigations to preempt cumulative toxicity.
Samuel Amo‐Tachie
wiley   +1 more source

Soluble Form of the (Pro)Renin Receptor Is Augmented in the Collecting Duct and Urine of Chronic Angiotensin II–Dependent Hypertensive Rats

, 2011
Renin synthesis and secretion by principal cells of the collecting duct are enhanced in angiotensin (Ang) II–dependent hypertension. The presence of renin/(pro)renin and its receptor, the (pro)renin receptor ([P]RR), in the collecting duct may provide a ...
Alexis A. Gonzalez, Lucienne S. Lara, Dale M. Seth, Christina Luffman, Minolfa C. Prieto   +4 more
core   +1 more source

Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin–angiotensin system [PDF]

, 2015
(Pro) renin receptor (PRR) is a new component of the renin-angiotensin system and regulates renin activity in vitro. Within the kidney, PRR is highly expressed in the renal medulla where its expression is induced by angiotensin II infusion. The objective
Shu-Feng Zhou, Wang, Fei, Lu, Xiaohan, Liu, Mi, Xiaohan Lu, Feng, Yumei, Zhou, Shu-Feng, Yumei Feng, Tianxin Yang, Mi Liu, Fei Wang, Yang, Tianxin   +11 more
core   +1 more source

Prediction of Gestational Diabetes Mellitus by Soluble (Pro)Renin Receptor During the First Trimester [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2013
There are currently no factors that have been shown to predict gestational diabetes mellitus (GDM) during early pregnancy. The soluble (pro)renin receptor [s(P)RR] may contribute to the development of GDM.The objective of the study was to determine whether plasma s(P)RR concentrations during early pregnancy are associated with the development of GDM ...
Noriyoshi, Watanabe, Satoshi, Morimoto, Takeo, Fujiwara, Tomo, Suzuki, Kosuke, Taniguchi, Fumiko, Mori, Takashi, Ando, Daisuke, Watanabe, Tadashi, Kimura, Haruhiko, Sago, Atsuhiro, Ichihara   +10 more
openaire   +2 more sources

(Pro)renin and (pro)renin receptor expression during kidney development in neonates [PDF]

, 2016
Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood.
Kagami, Shoji, ウルシハラ, マキ, テラダ, トモマサ, Terada, Tomomasa, 10403685, ナカガワ, リュウジ, 190, 寺田, 知正, 192, カガミ, ショウジ, 漆原, 真樹, 60248/profile-ja.html, 121729/profile-ja.html, 00224337, Saijo, Takahiko, Urushihara, Maki, 1631, 121546/profile-ja.html, 中川, 竜二, Nakagawa, Ryuji, 50403689, 香美, 祥二, サイジョウ, タカヒコ   +22 more
core  

Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells

, 2018
International audienceTGF-β1, which can cause renal tubular injury through a vacuolar-type H+-ATPase (V-ATPase)-mediated pathway, is induced by the glucose degradation product methylglyoxal to yield peritoneal injury and fibrosis.
Hirose, Takuo, Sato, Emiko, Ronco, Pierre, Muroya, Yoshikazu, Yusuke Ohsaki, Kazuhito Totsune, Nguyen, Geneviève, Geneviève Nguyen, Kinugasa, Satoshi, Takuo Hirose, Chika Takahashi, Sadayoshi Ito, Totsune, Kazuhito, Satoshi Kinugasa, Takefumi Mori, Rémi Piedagnel, Pierre M. Ronco, Ronco, Pierre, M, Ronco, Pierre,, Yoshikazu Muroya, Piedagnel, Rémi, Takahashi, Chika, Ito, Sadayoshi, Mori, Takefumi, Ohsaki, Yusuke, Ikuko Oba-Yabana, Oba-Yabana, Ikuko, Emiko Sato   +27 more
core   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source