Results 21 to 30 of about 9,609 (148)

Association between serum soluble (pro)renin receptor level and worsening of cardiac function in hemodialysis patients: A prospective observational study. [PDF]

PLoS One, 2020
The (pro)renin receptor ((P)RR) is cleaved to generate soluble (P)RR (s(P)RR), which reflects the status of the tissue renin-angiotensin system. Hemodialysis (HD) patients have a poor prognosis due to the increased prevalence of cardiovascular diseases ...
Amari Y, Morimoto S, Iida T, Takimoto H, Okuda H, Yurugi T, Oyama Y, Aoyama N, Nakajima F, Ichihara A.   +9 more
europepmc   +2 more sources

Soluble (Pro)renin Receptor and Obstructive Sleep Apnea Syndrome: Oxidative Stress in Brain? [PDF]

Int J Mol Sci, 2017
(Pro)renin receptor ((P)RR) is a multi-functional molecule that is related to both the renin-angiotensin system (RAS) and vacuolar H+-ATPase (v-ATPase), an ATP-dependent multi-subunit proton pump.
Takahashi K, Ohba K, Tajima K, Nishijima T, Sakurai S.   +4 more
europepmc   +2 more sources

Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy. [PDF]

PLoS One, 2017
(Pro)renin receptor [(P)RR], a new component of the tissue renin-angiotensin system (RAS), plays a crucial role in inflammation and angiogenesis in the eye, thus contributing to the development of proliferative diabetic retinopathy (PDR).
Hase K, Kanda A, Hirose I, Noda K, Ishida S.   +4 more
europepmc   +2 more sources

(Pro)renin Receptor And Its Soluble Form in Metabolic Dysfunction: Friend or Foe?

, 2023
(Pro)renin receptor is component of the renin angiotensin system which has been shown to be involved in several physiological and pathophysiological processes including blood pressure regulation and hypertension, water and electrolyte balance, kidney ...
Arthur, Gertrude
core   +1 more source

The role of (pro)renin receptor and its soluble form in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (Pro)renin receptor (PRR) was identified as a new member of RAS in 2002.
Boyang Wang, Boyang Wang, Boyang Wang, Haipeng Jie, Haipeng Jie, Shuangxi Wang, Bo Dong, Bo Dong, Bo Dong, Yunzeng Zou   +9 more
openaire   +3 more sources

Site-1 protease is required for the generation of soluble (pro)renin receptor [PDF]

The Journal of Biochemistry, 2016
The extracellular domain of the (pro)renin receptor [(P)RR] is cleaved to generate the soluble form of (P)RR [s(P)RR]. Multiple clinical studies have revealed the association between serum/plasma s(P)RR levels and certain diseases, thereby suggesting a potential role for s(P)RR as a disease biomarker. Here, we investigated whether site-1 protease (S1P)
Tsutomu, Nakagawa, Chiharu, Suzuki-Nakagawa, Akiko, Watanabe, Eriko, Asami, Mizuki, Matsumoto, Mami, Nakano, Akio, Ebihara, Mohammad Nasir, Uddin, Fumiaki, Suzuki   +8 more
openaire   +2 more sources

The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo. [PDF]

Hypertens Res
Preeclampsia is classified as new-onset hypertension coupled with gross endothelial dysfunction. Placental (pro)renin receptor ((P)RR) and plasma soluble (P)RR (s(P)RR) are elevated in patients with preeclampsia. Thus, we aimed to interrogate the role (P)
Schofield LG, Delforce SJ, Pryor JC, Endacott SK, Lumbers ER, Marshall SA, Pringle KG.   +6 more
europepmc   +2 more sources

Soluble (pro)renin receptor increased by hypoxia maintains oxidative metabolism in trophoblasts [PDF]

Journal of Molecular Endocrinology, 2020
Elevated soluble (pro)renin receptor (s(P)RR) concentration in maternal blood is associated with gestational hypertension and preeclampsia. Placenta has abundant expression of (P)RR, and the binding of (P)RR with pyruvate dehydrogenase E1 beta subunit (PDHB) is reported to maintain oxidative metabolism.
Chikahito, Suda, Junichi, Yatabe, Midori, Yatabe, Miki, Yarita, Atsuhiro, Ichihara   +4 more
openaire   +2 more sources

Soluble (Pro)Renin Receptor and Blood Pressure During Pregnancy [PDF]

Hypertension, 2012
The renin–angiotensin system is believed to influence blood pressure (BP) during pregnancy, but the associations between BP during pregnancy and the soluble form of the (pro)renin receptor (s[P]RR), a new component of the tissue renin–angiotensin system, remain undetermined.
Noriyoshi, Watanabe, Kanako, Bokuda, Takeo, Fujiwara, Tomo, Suzuki, Asako, Mito, Satoshi, Morimoto, Seung Chik, Jwa, Makiko, Egawa, Yoshie, Arai, Fumiaki, Suzuki, Haruhiko, Sago, Atsuhiro, Ichihara   +11 more
openaire   +2 more sources

Water Deprivation Increases (Pro)renin Receptor Levels in the Kidney and Decreases Plasma Concentrations of Soluble (Pro)renin Receptor

The Tohoku Journal of Experimental Medicine, 2016
Water deprivation activates the renin-angiotensin system. We have hypothesized that the renal expression of (pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, could be changed under dehydration. Moreover, plasma levels of soluble (P)RR (s(P)RR) comprising of the extracellular domain of (P)RR may reflect the renal (P)RR expression.
Tamura, Yuma, Mori, Nobuyoshi, Xu, Bin, Nakamura, Takahiro, Yamakoshi, Seiko, Hirose, Takuo, Ito, Osamu, Totsune, Kazuhito, Takahashi, Kazuhiro, Kohzuki, Masahiro   +9 more
openaire   +3 more sources