Results 21 to 30 of about 9,553 (133)
Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Xiaohan Lu, Chuanming Xu, Fei Wang
exaly +2 more sources
Enzymatic sources and physio-pathological functions of soluble (pro)renin receptor. [PDF]
Curr Opin Nephrol Hypertens, 2018 (Pro)renin receptor (PRR) belongs to type I transmembrane receptor family and binds both prorenin and renin, representing a potential regulator of the activity of the renin-angiotensin system. Soluble form of PRR (sPRR) is generated by intracellular protease-mediated cleavage of full-length PRR.
Zhu Q, Yang T.
europepmc +4 more sources
Soluble (pro)renin receptor as a potential therapy for diabetes insipidus. [PDF]
Am J Physiol Renal Physiol, 2018 The antidiuretic hormone vasopressin (VP) is produced by the hypothalamus and is stored and secreted from the posterior pituitary. VP acts via VP type 2 receptors (V2Rs) on the basolateral membrane of principal cells of the collecting duct (CD) to regulate fluid permeability.
Yang KT, Yang T, Symons JD.
europepmc +3 more sources
Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway
Frontiers in Physiology, 2021 Emerging evidence is showing that apelin plays an important role in regulating salt and water balance by counteracting the antidiuretic action of vasopressin (AVP). However, the underlying mechanism remains unknown. Here, we hypothesized that (pro) renin
Yanting Chen +8 more
doaj +1 more source
Serum soluble (pro)renin receptor levels in patients with essential hypertension. [PDF]
Hypertens Res, 2014 The (pro)renin receptor ((P)RR) is expressed in several tissues including kidney, heart and brain, and is thought to regulate the tissue renin-angiotensin system (RAS) through the non-proteolytic activation of prorenin. (P)RR is cleaved by furin to generate soluble (P)RR (s(P)RR), which is secreted into the extracellular space.
Morimoto S +9 more
europepmc +4 more sources
Frontiers in Pharmacology, 2023 Introduction: In the Doxorubicin (DOX)-induced nephropathy model, proteinuria is a manifestation of progressive kidney injury. The pathophysiology of renal illness is heavily influenced by the renin-angiotensin system (RAS).
Hui Fang +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Ectopic activation of renin-angiotensin-system contributes to cardiovascular and renal diseases. (Pro)renin receptor (PRR) binds to renin and prorenin, participating in the progression of nephrology.
Jing Zhang +3 more
doaj +1 more source
Biomolecules, 2022 The angiotensin-converting enzyme 2 (ACE2) is a type I integral membrane that exists in two forms: the first is a transmembrane protein; the second is a soluble catalytic ectodomain of ACE2.
Artemio García-Escobar +5 more
doaj +1 more source
Site-1 protease is required for the generation of soluble (pro)renin receptor [PDF]
The Journal of Biochemistry, 2016 The extracellular domain of the (pro)renin receptor [(P)RR] is cleaved to generate the soluble form of (P)RR [s(P)RR]. Multiple clinical studies have revealed the association between serum/plasma s(P)RR levels and certain diseases, thereby suggesting a potential role for s(P)RR as a disease biomarker. Here, we investigated whether site-1 protease (S1P)
Tsutomu, Nakagawa +8 more
openaire +2 more sources
Angiotensin-Converting Enzyme 2 Expression and Severity of SARS-CoV-2 Infection
Microorganisms, 2023 Angiotensin-converting enzyme 2 (ACE2), first discovered in 2000, serves as an important counterregulatory enzyme to the angiotensin II-mediated vasoconstrictive, pro-inflammatory, and pro-fibrotic actions of the renin–angiotensin system (RAS ...
Sarah Alabsi +3 more
doaj +1 more source