Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma [PDF]
Hypertension, 2009 The (pro)renin receptor [(P)RR] is a 35-kDa transmembrane protein that plays a pivotal role in angiotensin tissue generation and in nonproteolytic prorenin activation. We detected a soluble form of (P)RR [s(P)RR; 28 kDa] in the conditioned medium of cultured cells.
Aurélie Contrepas +2 more
exaly +4 more sources
Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 The extracellular domain of the (pro) renin receptor (PRR) is cleaved to produce a soluble (pro) renin receptor (sPRR) that is detected in biological fluid and elevated under certain pathological conditions.
Xiaohan Lu, Fei Wang, Chuanming Xu
exaly +3 more sources
American Journal of Physiology - Cell Physiology, 2017 Proteinuria is a characteristic of chronic kidney disease and also a causative factor that promotes the disease progression, in part, via activation of the intrarenal renin-angiotensin system (RAS).
Hui Fang, Chuanming Xu, Aihua Lu
exaly +3 more sources
Soluble pro renin receptor in elderly chronic heart failure patients
Frontiers in Bioscience, 2020 Overactivation of renin-angiotensin system (RAS) is one of the main pathophysiological features in the evolution of chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player in a tissue renin-angiotensin system (tissue RAS), which mediates tissue injury through fibrosis and hypertrophy of the affected organs in CHF ...
Danilo Obradovic +16 more
openaire +4 more sources
Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells [PDF]
Genes To Cells, 2020 Abstract(Pro)renin receptor ((P)RR) regulates the renin–angiotensin system and functions as an essential accessory subunit of vacuolar H+‐ATPase. There is accumulating evidence that shows close relationship between (P)RR and autophagy. Soluble (P)RR consisting of the extracellular domain of (P)RR is generated from (P)RR by proteolytic enzymes.
Koji Ohba
exaly +3 more sources
Novel sandwich ELISA for detecting the human soluble pro renin receptor
Frontiers in Bioscience - Elite, 2013 The (pro)renin receptor ((P)RR) plays a key role in the activation of the local renin-angiotensin system via interaction with renin and prorenin. A truncated form that is cleaved by furin, referred to as soluble (pro)renin receptor (s(P)RR), is secreted into the extracellular space. An accurate measurement of s(P)RR levels in vivo is an important issue
Atsuhiro Ichihara
exaly +3 more sources
Soluble (pro)renin receptor as a novel laboratory biomarker of atherosclerosis. [PDF]
Acta Biochim Biophys Sin (Shanghai)Liu C +10 more
europepmc +4 more sources
Potential of soluble (pro)renin receptor in kidney disease: can it go beyond a biomarker?
American Journal of Physiology - Renal Physiology, 2022 Tianxin Yang
exaly +2 more sources
Soluble (Pro)renin Receptor Is Adversely Associated with Indices of Left Ventricular Structure and Function: The African-PREDICT Study. [PDF]
J Cardiovasc Dev Dis, 2022 This study aims to compare soluble (pro)renin receptor [s(P)RR] levels between black and white adults and to explore the associations of left ventricular (LV) structure and function with s(P)RR in the total and ethnicity-stratified groups.
Gafane-Matemane LF +4 more
europepmc +2 more sources
Prediction of response to medical therapy by serum soluble (pro)renin receptor levels in Graves' disease. [PDF]
PLoS One, 2018 Antithyroid drugs are generally selected as the first-line treatment for Graves' Disease (GD); however, the existence of patients showing resistance or severe side effects to these drugs is an important issue to be solved. The (pro)renin receptor [(P)RR]
Mizuguchi Y +11 more
europepmc +2 more sources