Results 71 to 80 of about 3,903,665 (206)

Receptor-associated prorenin system in the pathogenesis of retinal diseases [PDF]

Frontiers in Bioscience, 2012
Receptor-associated prorenin system (RAPS) refers to the pathogenic mechanisms whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling through the receptor. Although we found significant involvement of angiotensin II type 1 receptor (AT1-R) in intraocular
Shingo, Satofuka, Atsuhiro, Kanda, Susumu, Ishida   +2 more
openaire   +2 more sources

Obesity Human Soluble Prorenin Receptor Expressed in Adipose Tissue Improves Insulin Sensitivity and Endothelial Function in Obese Female Mice

bioRxiv
Soluble prorenin receptor (sPRR) is a component of the renin-angiotensin system (RAS) identified as a plasma biomarker for human metabolic disease. However, what tissue source of sPRR is implicated in the modulation of metabolic function remains unclear.
Gertrude Arthur, Nermin Ahmed, Kellea Nichols, Audrey Poupeau, Katelyn Collins, Volkhard Lindner, A. Loria   +6 more
semanticscholar   +1 more source

Prorenin anno 2008 [PDF]

, 2008
For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest ...
Batenburg, Wendy, Esch, J.H.M. (Joep) van, Krop, M. (Manne), Manne Krop, Esch, Joep, Krop, Manne, Joep H. M. van Esch, Danser, A.H.J. (Jan), Wendy W. Batenburg, A. H. Jan Danser, Batenburg, W.W. (Wendy), Danser, Jan   +11 more
core   +1 more source

Pathologic Roles of Receptor-Associated Prorenin System in Idiopathic Epiretinal Membrane [PDF]

, 2017
Receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates tissue renin-angiotensin system (RAS) and RAS-independent signaling via (P)RR. The aim of this study is
Dong, Yoko, Noda, Kousuke, Atsuhiro Kanda, Wataru Saito, Kousuke Noda, Susumu Ishida, Kanda, Atsuhiro, Saito, Wataru, Ishida, Susumu, Yoko Dong   +9 more
core   +1 more source

Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

Cells, 2021
We investigated the expression of components of the renin-angiotensin system (RAS) by cancer stem cell (CSC) subpopulations in metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC).
Sam Siljee, Olivia Buchanan, Helen D. Brasch, Nicholas Bockett, Josie Patel, Erin Paterson, Gordon L. Purdie, Paul F. Davis, Tinte Itinteang, Swee T. Tan   +9 more
doaj   +1 more source

The soluble form of the prorenin receptor disturbed glucose/insulin homeostasis and leptin secretion in obese male mice

The FASEB Journal, 2020
Obesity is one of the major causes of the rise in prevalence of the metabolic syndrome and hypertension. We recently found that the circulating form of the prorenin receptor (sPRR) increased during the development of obesity.
Audrey Poupeau, E. Gatineau, Frederique Yiannikouris   +2 more
semanticscholar   +1 more source

(Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells

Frontiers in Pharmacology, 2019
The binding of prorenin to the (pro)renin receptor (PRR) triggers the activation of MAPK/ERK1/2 pathway, induction of cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), and the induction of transforming growth factor β
Cristian Reyes-Martinez, Quynh My Nguyen, Modar Kassan, Alexis A. Gonzalez   +3 more
doaj   +1 more source

Increased (Pro)renin Receptor Expression in the Hypertensive Human Brain

Frontiers in Physiology, 2020
Overactivation of the renin-angiotensin system (RAS) – a central physiological pathway involved in controlling blood pressure (BP) – leads to hypertension.
Minhazul Mohsin, Minhazul Mohsin, Lucas A. C. Souza, Lucas A. C. Souza, Simindokht Aliabadi, Simindokht Aliabadi, Caleb J. Worker, Caleb J. Worker, Silvana G. Cooper, Silvana G. Cooper, Sanzida Afrin, Sanzida Afrin, Yuki Murata, Zhenggang Xiong, Yumei Feng Earley, Yumei Feng Earley   +15 more
doaj   +1 more source

Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis

Scientific Reports, 2023
Glioblastoma is characterized by a strong self-renewal potential and poor differentiated state. We have reported previously that the (pro)renin receptor [(P)RR] is a potential target for glioma therapy by silencing the (P)RR gene.
Takeshi Fujimori, Yuki Shibayama, Takahiro Kanda, Kenta Suzuki, Daisuke Ogawa, Ryou Ishikawa, Kyuichi Kadota, Toru Matsunaga, Takashi Tamiya, Akira Nishiyama, Keisuke Miyake   +10 more
doaj   +1 more source

α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions

Frontiers in Cardiovascular Medicine, 2021
Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na+ handling.
Aarón Guerrero, Bruna Visniauskas, Pilar Cárdenas, Stefanny M. Figueroa, Jorge Vivanco, Nicolas Salinas-Parra, Patricio Araos, Quynh My Nguyen, Modar Kassan, Cristián A. Amador, Minolfa C. Prieto, Alexis A. Gonzalez   +11 more
doaj   +1 more source