Results 91 to 100 of about 1,765 (116)
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Journal de la Societe de biologie, 2010
The renin-angiotensin system (RAS) is one of the most important systems in physiology and in pathology. The (pro)renin receptor [(P)RR] is a new component of the system that has attracted much attention, being potentially a new therapeutic target, because the binding of renin and of prorenin triggers the activation of the mitogen-activated protein ...
Diane, Bracquart +3 more
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The renin-angiotensin system (RAS) is one of the most important systems in physiology and in pathology. The (pro)renin receptor [(P)RR] is a new component of the system that has attracted much attention, being potentially a new therapeutic target, because the binding of renin and of prorenin triggers the activation of the mitogen-activated protein ...
Diane, Bracquart +3 more
openaire +1 more source
Of Wnt, Prorenin Receptor, and V-ATPase
Science, 2010A dual-function protein acts as an adaptor in a major developmental signaling pathway.
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Pathologic roles of prorenin and (pro)renin receptor in the eye
Frontiers in Bioscience, 2008Recent reports indicated that tissue renin-angiotensin system (RAS) was upregulated and angiotensin II type 1 receptor signaling plays crucial roles in ocular inflammation and neovascularization; however, the precise mechanism for activating tissue RAS had not been defined until recently.
Shingo, Satofuka +5 more
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Renin and Prorenin Receptor in Hypertension: What’s New?
Current Hypertension Reports, 2010The (pro)renin receptor, PRR, was initially characterized as a component of the renin-angiotensin system (RAS). PRR-bound renin and prorenin display increased enzymatic activity, and binding activates intracellular signaling, upregulating the expression of profibrotic proteins.
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Prorenin and the (Pro)renin Receptor in Retinal Pathology
Current Hypertension Reviews, 2009Blockade of angiotensin II (Ang II) has potential therapeutic benefit for ocular diseases including diabetic retinopathy and retinopathy of prematurity. Perhaps the most studied is diabetic retinopathy where angiotensin converting enzyme inhibition and angiotensin type 1 receptor blockade (AT1-RB) is beneficial.
Jennifer Wilkinson-Berka +2 more
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Frontiers in Bioscience, 2008
Prorenin is the enzymatically inactive precursor of renin. Recent interest has focused on the nonproteolytic activation of prorenin by antibodies and renin/prorenin receptors since markedly increased levels of circulating prorenin have been associated with both physiological and pathological changes. Prorenin has been considered to be activated in vivo
M Nasir, Uddin +5 more
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Prorenin is the enzymatically inactive precursor of renin. Recent interest has focused on the nonproteolytic activation of prorenin by antibodies and renin/prorenin receptors since markedly increased levels of circulating prorenin have been associated with both physiological and pathological changes. Prorenin has been considered to be activated in vivo
M Nasir, Uddin +5 more
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[Systemic distribution of prorenin and its receptor].
Nihon rinsho. Japanese journal of clinical medicine, 2012The (pro)renin receptor was first identified as a 350-amino acid protein with a single transmembrane domain. This receptor binds to prorenin to mediate its dual functions: activation of ERK1/2 independently from angiotensin II generation and induction of full enzymatic activity to initiate angiotensin II-dependent effects.
Yuji, Tani, Masayoshi, Shichiri
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The placental prorenin/prorenin receptor system
Placenta, 2017Samantha Rodrigues +5 more
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Laughter modulates prorenin receptor gene expression in patients with type 2 diabetes
Journal of Psychosomatic Research, 2007Miyo Hori, Fumiaki Suzuki
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