Results 91 to 100 of about 3,903,665 (206)

Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway

Frontiers in Physiology, 2021
Emerging evidence is showing that apelin plays an important role in regulating salt and water balance by counteracting the antidiuretic action of vasopressin (AVP). However, the underlying mechanism remains unknown. Here, we hypothesized that (pro) renin
Yanting Chen, Chuanming Xu, Chuanming Xu, Jiajia Hu, Mokan Deng, Qixiang Qiu, Shiqi Mo, Yanhua Du, Tianxin Yang   +8 more
doaj   +1 more source

The influence of prorenin/(pro)renin receptor on progesterone secretion by the bovine corpus luteum.

Animal Reproduction Science, 2022
The aim of this study was to evaluate the role of prorenin/(pro)renin receptor activation on luteal progesterone (P4) secretion. Our hypothesis was that the nonproteolytic activation of (pro)renin receptor [P(RR)] is part of the regulatory mechanism ...
A. Dau, P. D. da Rosa, J. D. dos Santos, J. Ferst, M. D. de Macedo, M. Rovani, F. Comim, A. Antoniazzi, B. Gasperin, R. Ferreira, P. B. Gonçalves   +10 more
semanticscholar   +1 more source

Gestational age and fetal hypothyroidism Alter the porcine thyroid and local hepatic and renal renin‐angiotensin systems

Physiological Reports, Volume 13, Issue 17, September 2025.
Abstract This study was conducted to examine the ontogeny of and interactions between the thyroid system and local renin‐angiotensin systems (RAS) in the porcine fetus. N = 24 pregnant gilts were split into two groups, receiving either a daily dose of methimazole to induce fetal hypothyroidism, or a daily sham control. Within each group, treatment of n 
Alyssa A. Smith, J. Alex Pasternak
wiley   +1 more source

The Pathological Role of Pro(Renin) Receptor in Renal Inflammation

Journal of Experimental Pharmacology, 2021
Syed S Quadri,1 Caleb Cooper,2 Dawood Ghaffar,1 Hitesh Vaishnav,1 Ludmila Nahar3 1DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Knoxville, TN, USA; 2DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN,
Quadri SS, Cooper C, Ghaffar D, Vaishnav H, Nahar L   +4 more
doaj  

Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours

Diagnostics, 2021
(1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour progression.
Jon Danel Solano-Iturri, Enrique Echevarría, Miguel Unda, Ana Loizaga-Iriarte, Amparo Pérez-Fernández, Javier C. Angulo, José I. López, Gorka Larrinaga   +7 more
doaj   +1 more source

Differential Roles of Angiotensin A and Alamandine in Parkinson's Disease: A Therapeutic Perspective on Nonclassical RAS Pathways

Brain and Behavior, Volume 15, Issue 8, August 2025.
The role of the Classical and Non‐Classical RAS pathway in Parkinson's disease: Pathogenesis and Therapeutic strategies. PD, Parkinson's disease; DNs, Dopaminergic neurons; SN, Substantia Nigra; α‐syn, alpha‐synuclein; RAS, renin‐angiotensin system; Ang II, Angiotensin II; AT1R, Angiotensin II type 1 Receptor; ACE2, angiotensin‐converting enzyme 2; Ang
Ghadah H. Alshehri, Hayder M. Al‐kuraishy, Ali K. Albuhadily, Ali I. Al‐Gareeb, Amany S. Aboutaleb, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor

, 2007
OBJECTIVE: Mannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such binding contributes to renin/prorenin clearance but not to angiotensin generation. Here, we evaluated the kinetics of renin/prorenin binding to the recently discovered
Burckle, C.A., Nguyen, G., Batenburg, W.W., Danser, A.H.J., Krop, M., Garrelds, I.M., de Bruin, R.J.A., Mueller, D.N., de Vries, R., Bader, M.   +9 more
core   +1 more source

Purification of functional baculovirus particles from silkworm larval hemolymph and their use as nanoparticles for the detection of human prorenin receptor (PRR) binding

BMC Biotechnology, 2011
Background Baculovirus, which has a width of 40 nm and a length of 250-300 nm, can display functional peptides, receptors and antigens on its surface by their fusion with a baculovirus envelop protein, GP64.
Park Enoch Y, Suzuki Fumiaki, Kato Tatsuya   +2 more
doaj   +1 more source

Preascitic Sodium Retention in Cirrhosis: A Role for Disregulated Proteolysis by Proprotein Convertases?

Liver International Communications, Volume 6, Issue 2, June 2025.
ABSTRACT Loss of effective arterial blood volume, secondary hyperaldosteronism, adrenergic activation and nonosmotic hypersecretion of vasopressin induce sodium and water retention in cirrhotic patients with ascites. The mechanisms of sodium retention that precede ascites formation remain elusive.
Giovanni Sansoè, Manuela Aragno, Florence Wong   +2 more
wiley   +1 more source

Methylation of Promoter Regions of Genes of the Human Intrauterine Renin Angiotensin System and Their Expression

International Journal of Endocrinology, 2015
The intrauterine renin angiotensin system (RAS) is implicated in placentation and labour onset. Here we investigate whether promoter methylation of RAS genes changes with gestation or labour and if it affects gene expression.
Shane D. Sykes, Carolyn Mitchell, Kirsty G. Pringle, Yu Wang, Tamas Zakar, Eugenie R. Lumbers   +5 more
doaj   +1 more source