Results 111 to 120 of about 3,903,665 (206)

Biochemical properties of renin and prorenin binding to the (pro)renin receptor [PDF]

Hypertension Research, 2009
The discovery of (pro)renin receptor, (P)RR, has made the renin-angiotensin system (RAS) more multifaceted. Interaction of renin and prorenin with this receptor has set a new perspective about the physiological functions, activation mechanism and pathophysiological roles of renin/prorenin.
A H M Nurun, Nabi, Fumiaki, Suzuki
openaire   +2 more sources

Phosphoproteomics for studying signaling pathways evoked by hormones of the renin‐angiotensin system: A source of untapped potential

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract The Renin‐Angiotensin System (RAS) is a complex neuroendocrine system consisting of a single precursor protein, angiotensinogen (AGT), which is processed into various peptide hormones, including the angiotensins [Ang I, Ang II, Ang III, Ang IV, Ang‐(1–9), Ang‐(1–7), Ang‐(1–5), etc] and Alamandine‐related peptides [Ang A, Alamandine, Ala‐(1–5)],
Igor Maciel Souza‐Silva, Victor Corasolla Carregari, U. Muscha Steckelings, Thiago Verano‐Braga   +3 more
wiley   +1 more source

Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors [PDF]

, 2001
ACE inhibitors improve endothelial dysfunction, possibly by blocking endothelial angiotensin production. Prorenin, through its binding and activation by endothelial mannose 6-phosphate (M6P) receptors, may contribute to ...
van den Eijnden, MMED (Mark), Reudelhuber, T.L., Schalekamp, M.A.D.H. (Maarten), Derkx, F.H.M. (Frans), Saris, J.J. (Jasper), Saris, Jasper; id_orcid, Sluiter, W. (Wim), Sluiter, Wim, Schalekamp, MADH (Maarten), Bruin, R.J.A. (René) de, Danser, A.H.J. (Jan), Saris, Jasper, Wit, E. (Emmie) de, Danser, Jan, Bruin, Rene, de Wit, E (Emmie), Reudelhuber, TL, Derkx, FHM, Eijnden, M.M.E.D. (Mark) van den   +18 more
core   +2 more sources

The Role of Angiotensin‐II Infusion in an Infant With Autosomal Recessive Polycystic Kidney Disease Postbilateral Nephrectomies and Refractory Hypotension in the Neonatal Period

Case Reports in Nephrology, Volume 2025, Issue 1, 2025.
Autosomal recessive polycystic kidney disease (ARPKD) is a form of hereditary cystic disease with a highly variable phenotypic expression that ultimately leads to chronic kidney disease. Severe cases may warrant surgical intervention with unilateral or bilateral nephrectomy to alleviate thoracic and abdominal compression from massive nephromegaly ...
Ana Nevarez Gilbert, Adrianne Rahde Bischoff, Kyle Merrill, Yoshihide Fujigaki   +3 more
wiley   +1 more source

Expression of cardiac tissue prorenin, renin, (pro)renin receptor, angiotensinogen and angiotensin II AT1 receptor.

, 2015
Expressions of cardiac tissue (a) prorenin, (b) renin, (c) (pro)renin receptor, (d) angiotensinogen and (e) angiotensin AT1 receptor in the WKY + normal-salt group (WKY+NS), WKY + high-salt group (WKY+HS), SHR + normal-salt group (SHR+NS) and SHR + high ...
Takuma Aoyama (675581), Shingo Minatoguchi (709054), Fumiaki Suzuki (709059), Masamitsu Iwasa (709055), Chiharu Yokoyama (675582), Atsushi Mikami (709058), Itta Kawamura (709057), Hisaaki Komaki (709053), Shinya Minatoguchi (675586), Yuka Hayakawa (675583), Masanori Kawasaki (274320), Yoshihisa Yamada (709056), Chihiro Okamoto (709052), Kazuhiko Nishigaki (675585)   +13 more
core   +1 more source

A Benign Renal Tumor With Serious Consequences: A Case Report of Juxtaglomerular Cell Tumor and Chronic Renal Disease in a Teenager

Case Reports in Pediatrics, Volume 2025, Issue 1, 2025.
Juxtaglomerular cell tumor (JGCT), or reninoma, is a rare benign renal neoplasm. It is characterized by severe hypertension and hypokalemia due to excessive renin produced from the juxtaglomerular apparatus on the afferent arteriole of the glomerulus. Herein, we report a case of JGCT in a 15‐year‐old female who presented with severe hypertension.
Rachael Courtney, Erin Dahlinghaus, Abiodun Omoloja, Jeffrey T. Boyd, Michelle Smith, Laura Biederman, Israel Ndengabaganizi, Daniel Keith Robie, Ahmad Al Dughiem, Andrea Scaramuzza   +9 more
wiley   +1 more source

The (Pro)renin Receptor: Moving away from Prorenin? [PDF]

, 2014
__Abstract__ The function of prorenin, the precursor of renin, remained unknown until the discovery of the (pro)renin receptor ((P)RR). (Pro)renin binding to this receptor allows angiotensin generation and induces signaling.
Lu, X. (Xifeng)
core   +1 more source

Critical Review of Prorenin and (Pro)renin Receptor Research [PDF]

Hypertension, 2008
The renin-angiotensin system (RAS) plays an important role in cardiovascular and renal physiology and disease, and the benefits of angiotensin-converting enzyme inhibitor, angiotensin type 1 receptor blocker, and renin inhibitor therapies are mediated in part by their modification of the levels and actions of angiotensin peptides.
openaire   +2 more sources

The effect of 30 min of supine rest on plasma renin concentrations in paediatric patients

Acta Paediatrica, Volume 113, Issue 11, Page 2473-2478, November 2024.
Abstract Aim The aim of this study is to interpret plasma renin concentrations (PRCs) correctly in a clinical setting, it is essential to understand to what extent physical activity influences the concentration. Reference values for different postural positions exist for adults, but data for children are sparse.
D. F. Al‐Zoubaidi, T. H. Johannsen, N. R. Jørgensen, K. M. Main   +3 more
wiley   +1 more source

Abstract 4136: Effect of prorenin receptor PRR knock down and telmisartan on endometrial cancer growth

, 2017
Endometrial cancer is the most common gynaecological malignancy and its incidence is increasing. Tissue renin angiotensin systems (RAS) are known to stimulate angiogenesis, cell proliferation and migration.
Sarah J. Delforce, Riazuddin Mohammed, Yu Wang, Eugenie R. Lumbers, Kirsty G. Pringle, Nicole M. Verrills   +5 more
core   +1 more source