Results 131 to 140 of about 3,903,665 (206)

Expression and functional role of the prorenin receptor in the human adrenocortical zona glomerulosa and in primary aldosteronism [PDF]

, 2015
OBJECTIVES: Prorenin can be detected in plasma of hypertensive patients. If detected in patients with primary aldosteronism could implicate prorenin in the development of primary aldosteronism.
Anna Sandra Belloni, Rossi, Gian Paolo, Juerg Nussberger, Petrelli, Lucia, Livia Lenzini, RECARTI, CHIARA, Giulio Ceolotto, SECCIA, TERESA MARIA, ROSSI, GIANPAOLO, CAROCCIA, BRASILINA, Lucia Petrelli, William E. Rainey, Nussberger, Juerg, Belloni, Anna Sandra, Gonzales-Campos, Abril, Lenzini, Livia, Ceolotto, Giulio, Abril Gonzales Campos, Rainey, William E.   +18 more
core   +1 more source

(Pro)renin receptor is required for prorenin-dependent and -independent regulation of vacuolar H⁺-ATPase activity in MDCK.C11 collecting duct cells

, 2013
Prorenin binding to the prorenin receptor [(P)RR] results in nonproteolytic activation of prorenin but also directly (i.e., independent of angiotensin generation) activates signal transduction cascades that can lead to the upregulation of profibrotic ...
Lu, X. (Xifeng), Wagner, Carsten A, Garrelds, I.M. (Ingrid), Danser, A H Jan, Meima, M.E. (Marcel), Lu, Xifeng, Wagner, C.A. (Carsten), Garrelds, Ingrid M, Meima, Marcel E, Danser, A.H.J. (Jan), Van den Berg - Garrelds, Ingrid; id_orcid, Meima, Marcel, Wagner, CA, Danser, Jan, Van den Berg - Garrelds, Ingrid, Lu, XF   +15 more
core   +2 more sources

The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesis.

PLoS ONE, 2013
The ATPase 6 accessory protein 2 (ATP6AP2)/(pro)renin receptor (PRR) is essential for the biogenesis of active vacuolar H(+)-ATPase (V-ATPase). Genetic deletion of ATP6AP2/PRR causes V-ATPase dysfunction and compromises vesicular acidification.
Kenichiro Kinouchi, Atsuhiro Ichihara, Motoaki Sano, Ge-Hong Sun-Wada, Yoh Wada, Hiroki Ochi, Toru Fukuda, Kanako Bokuda, Hideaki Kurosawa, Naohiro Yoshida, Shu Takeda, Keiichi Fukuda, Hiroshi Itoh   +12 more
doaj   +1 more source

Roles and functions of Atp6ap2 in the brain

Neural Regeneration Research, 2018
The classical renin-angiotensin system (RAS) in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure.
Alexander Bracke, Oliver von Bohlen und Halbach   +1 more
doaj   +1 more source

Role of autophagy and evaluation the effects of microRNAs 214, 312, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis.

Life Science, 2021
D. Yıldırım, O. Bender, Zehra Firat Karagoz, F. Helvacioglu, Mukadder Ayşe Bilgiç, A. Akçay, N. Ruzgaresen   +6 more
semanticscholar   +1 more source

Increased Prorenin Expression in the Kidneys May Be Involved in the Abnormal Renal Function Caused by Prolonged Environmental Exposure to Microcystin-LR

Toxics
Toxic algae in eutrophic lakes produce cyanotoxic microcystins. Prior research on the effect of microcystin-LR in the kidney utilized intraperitoneal injections, which did not reflect natural exposure.
Yuuka Hitsuda, Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Kohji Nishimura, Ayumi Hashiguchi, Hideaki Maseda, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu   +11 more
doaj   +1 more source

Diabetic complications: A role for the prorenin-(pro)renin receptor-TGF-beta(1) axis?

, 2009
Morbidity and mortality of diabetes mellitus are strongly associated with cardiovascular disease including nephropathy. A discordant tissue renin-angiotensin system (RAS) might be a mediator of the endothelial dysfunction leading to both micro- and ...
Heuvel, Mieke, Batenburg, Wendy, van den Heuvel, Mieke, Danser, A.H. Jan, Batenburg, Wendy W., Danser, Jan   +5 more
core   +1 more source

Species specificity of prorenin binding to the pro renin receptor in vitro

Frontiers in Bioscience, 2010
In this study, binding properties of human prorenin to rat (pro)renin receptor (r(P)RR) and rat prorenin to human (pro)renin receptor (h(P)RR) were elucidated in vitro to investigate species specificity of prorenin bindings to (P)RR. Both (P)RRs were expressed in vitro based on wheat germ lysate and purified using His trap column.
Kazal Boron, Biswas, A H M Nurun, Nabi, Yoshie, Arai, Tsutomu, Nakagawa, Akio, Ebihara, Fumiaki, Suzuki   +5 more
openaire   +2 more sources

Assessment of the (Pro)renin Receptor Protein Expression in Organs

Current Issues in Molecular Biology
The (pro)renin receptor ((P)RR) is an essential component of the renin–angiotensin system (RAS) as a specific single-pass transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of ...
Teng-Yao Yang, Pey-Jium Chang, Yu-Shien Ko, Siou-Ru Shen, Shun-Fu Chang   +4 more
doaj   +1 more source

Prorenin and the (pro)renin receptor--an update [PDF]

Nephrology Dialysis Transplantation, 2007
Danser, Jan, Batenburg, Wendy, Esch, Joep   +2 more
openaire   +3 more sources