Results 141 to 150 of about 3,903,665 (206)

Renin- and prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor: does (pro)renin-(pro)renin receptor interaction actually occur?

, 2011
Renin/prorenin binding to the (pro)renin receptor ([P]RR) results in direct (angiotensin-independent) second-messenger activation in vitro, whereas in vivo studies in rodents overexpressing prorenin (≈400-fold) or the (P)RR do not support such activation.
Batenburg, Wendy, Muller, DN, Leijten, F., Lu, X., Leijten, Frank, Frank Leijten, Batenburg, W.W., Mueller, D.N., Danser, Jan, Ulrike Maschke, Xifeng Lu, A.H. Jan Danser, Maschke, U., Danser, A.H.J., Dominik N. Müller, Maschke, U, Wendy W. Batenburg, Lu, XF   +17 more
core   +1 more source

Effect of active vitamin D on renin in renal tubular epithelial cells under high glucose conditions

Linchuang shenzangbing zazhi
Objective To explore the effect of active vitamin D on renin, (pro) renin receptor (PRR) and NF-κB in rat renal tubular epithelial (NRK-52E) cells in high glucose conditions and elucidate the role of NF-κB.
Yi-qing He, Wen-wen Liao, Mi Tao, Yu-yan Li, Ping Gao   +4 more
doaj   +1 more source

Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats

, 2018
Plasma prorenin is commonly elevated in diabetic patients and appears to predict the development of diabetic nephropathy. However, the pathological role of prorenin is unclear.
Bin Wang, Jie Wu, Chunyan Gu, E. Dale Abel, Yufeng Huang, Guangyu Zhou, Alfred K. Cheung   +6 more
core   +1 more source

Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide

, 2008
The recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by activating mitogen-activated protein kinases and promotes nonproteolytic prorenin activation.
Burckle, C., Danser, A.H., Nguyen, G., Kvakan, H, Muller, DN, Wellner, M, Nguyen, G, Burckle, C. (Celine), Fiebeler, A, Mazak, I. (Istvan), Luft, F.C., Mueller, D.N., Mazak, I, Fiebeler, A. (Anette), Contrepas, A, Wellner, M., Wellner, M. (Maren), Maschke, U., Dechend, R, Luft, F.C. (Friedrich), Feldt, S. (Sandra), Maschke, U, Bader, M., Batenburg, W.W. (Wendy), Müller, D. (Dominik), Batenburg, Wendy, Feldt, S., Bader, M. (Michael), Dechend, R. (Ralf), Contrepas, A., Batenburg, W.W., Feldt, S, Danser, A.H.J. (Jan), Fiebeler, A., Dechend, R., Danser, Jan, Contrepas, A. (Aurelie), Burckle, C, Maschke, U. (Ulrike), Bader, M, Mazak, I., Kvakan, H., Kvakan, H. (Heda), Nguyen, G. (Genevieve), Luft, FC   +44 more
core   +1 more source

Cardiomyocytes bind and activate native human prorenin : role of soluble mannose 6-phosphate receptors [PDF]

, 2001
Cardiomyocytes bind, internalize, and activate recombinant human prorenin through mannose 6-phosphate/insulin-like growth factor II (M6P/IGFII) receptors. To investigate whether this also applies to native human prorenin,
Lamers, J.M.J. (Jos), Derkx, F.H.M. (Frans), Schalekamp, M.A.D.H. (Maarten), Saris, J.J. (Jasper), Danser, A.H.J. (Jan), Saxena, P.R. (Pramod Ranjan)   +5 more
core  

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

Journal of Clinical Investigation, 2002
G. Nguyen, F. Delarue, Céline Burcklé, L. Bouzhir, T. Giller, J. Sraer   +5 more
semanticscholar   +1 more source

Prorenin and diabetes mellitus [PDF]

, 1993
The renin-angiotensin system (RAS) plays an important role in the regulation of arterial blood pressure and water and salt regulation. Until recently this system was considered to be exclusively a circulating endocrine system. Circulating renin, released
Franken, A.A.M. (Anton)
core  

Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia

International Journal of Endocrinology
Purpose. Sarcopenia is an advancing and widespread skeletal muscle condition characterized by the depletion of skeletal muscle mass. The (pro)renin receptor ((P)RR) is a multifaceted protein with both pathophysiological and physiological functions. (P)RR
Satoshi Morimoto, Haruki Sasaki, Chikahito Suda, Atsuhiro Ichihara, Nobuyuki Ura   +4 more
doaj   +1 more source

Prorenin receptor: no role in the RAS? [PDF]

Nature Reviews Nephrology, 2016
openaire   +1 more source

Effects of fetal sex on expression of the (pro)renin receptor and genes influenced by its interaction with prorenin in human amnion

Males are more likely to be born preterm than females. The causes are unknown, but it is suggested that intrauterine tissues regulate fetal growth and survival in a sex-specific manner.
Alison Conquest (14156960), Carolyn Mitchell (21270785), Eugenie Lumbers (21134015), Kirsty Pringle (21129401), Tamas Zakar (21132203)   +4 more
core