Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control
Molecular Metabolism, 2016 Background: Hypertension and obesity are highly interrelated diseases, being critical components of the metabolic syndrome. Despite the growing prevalence of this syndrome in the world population, efficient therapies are still missing.
Soledad Pitra +2 more
doaj +1 more source
Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies
Journal of Cellular and Molecular Medicine, Volume 28, Issue 17, September 2024.Abstract Cathepsin B (CTSB) is a member of the cysteine protease family, primarily responsible for degrading unnecessary organelles and proteins within the acidic milieu of lysosomes to facilitate recycling. Recent research has revealed that CTSB plays a multifaceted role beyond its function as a proteolytic enzyme in lysosomes.
Zhulan Cai, Shunyao Xu, Chen Liu
wiley +1 more source
Acute, pro‐contractile effects of prorenin on rat mesenteric arteries
, 2023 Prorenin and the prorenin receptor ((P)RR) are important, yet controversial, members of the renin–angiotensin–aldosterone system. The ((P)RR) is expressed throughout the body, including the vasculature, however, the direct effect of prorenin on arterial ...
Greenstein, Adam; id_orcid +8 more
core +1 more source
Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients.
PLoS ONE, 2016 The (pro)renin receptor [(P)RR] is cleaved by furin to generate soluble (P)RR [s(P)RR], which reflects the status of the tissue renin-angiotensin system. Hemodialysis patients have advanced atherosclerosis.
Yoshifumi Amari +4 more
doaj +1 more source
Wnt signaling in cell adhesion, development, and colon cancer
IUBMB Life, Volume 76, Issue 7, Page 383-396, July 2024.Abstract Wnt signaling is essential for embryonic development, influencing processes such as axis formation, cell proliferation and differentiation, cell fate decisions, and axon guidance. It also plays a role in maintaining tissue homeostasis in adult organisms.
Nydia Tejeda‐Muñoz, Kuo‐Ching Mei
wiley +1 more source
Vacuolar H+‐ATPase in Diabetes, Hypertension, and Atherosclerosis
Microcirculation, Volume 31, Issue 5, July 2024.ABSTRACT Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It acts as a proton pump and as such is responsible for regulating pH in lysosomes, endosomes, and the extracellular space.
Na Wang, Liwei Ren, A. H. Jan Danser
wiley +1 more source
Decidualisation of human endometrial stromal cells is associated with increased expression and secretion of prorenin [PDF]
, 2015 Background: In pregnancy, the decidualised endometrium expresses high levels of prorenin and other genes of the renin-angiotensin system (RAS) pathway.
Logan, Philip C. +6 more
core +1 more source
MicroRNA-148a regulates low-density lipoprotein metabolism by repressing the (pro)renin receptor.
PLoS ONE, 2020 High plasma LDL cholesterol (LDL-c) concentration is a major risk factor for atherosclerosis. Hepatic LDL receptor (LDLR) regulates LDL metabolism, and thereby plasma LDL-c concentration.
Na Wang +9 more
doaj +1 more source
Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II [PDF]
, 2002 Cardiomyocytes bind, internalize, and activate prorenin, the inactive precursor of renin, via a mannose 6-phosphate receptor (M6PR)--dependent mechanism. M6PRs couple directly to G-proteins. To investigate whether prorenin binding to
van den Eijnden, MMED (Mark) +18 more
core +2 more sources
, 2008 The discovery of a (pro)renin receptor [(P)RR] and the introduction of renin inhibitors in the clinic have brought renin and prorenin back into the spotlight.
Geneviève Nguyen +5 more
core +2 more sources