Results 81 to 90 of about 3,903,665 (206)

Sex‐specific difference in adipose tissue and blood pressure control in a new mouse model expressing human soluble prorenin receptor in adipocytes

Current Developments in Nutrition, 2020
Sex difference exists in the prevalence of obesity associated with hypertension, however, underlying mechanisms responsible are not completely understood.
Kellea Nichols, Audrey Poupeau, E. Gatineau, Gertrude Arthur, M. Gong, V. Lindner, Frederique Yiannikouris   +6 more
semanticscholar   +1 more source

Prorenin and the (Pro)renin Receptor in Ocular Pathology [PDF]

The American Journal of Pathology, 2008
This commentary reports on the protective effects of a (pro)renin receptor inhibitor in an experimental model of age-related macular degeneration.
openaire   +2 more sources

Interaction between nuclear‐translocated cellular communication network factor 2 and purine‐rich box 1 regulates the expression of fibrosis‐related genes

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Although cellular communication network factor 2 (CCN2) is secreted out to the extracellular environment, intracellular CCN2 rather than re‐incorporated CCN2 from the outside may be involved in its translocation into the nuclei, because translocation of CCN2 into the nucleus was not disturbed by soluble heparin.
Xuan Thi Nguyen, Satoshi Kubota, Masaharu Takigawa, Takashi Nishida   +3 more
wiley   +1 more source

Prorenin engages the (pro) renin receptor like renin and both ligand activities are unopposed by aliskiren

, 2008
Objectives Inhibition of (pro) renin receptor activation was demonstrated to inhibit or even abolish the development of end-organ damage in animal models.
Goebel, M, Gust, R, Kirsch, S, Kintscher, U, Schefe, JH, Funke-Kaiser, H, Neumann, C, Unger, T, Danser, Jan   +8 more
core   +1 more source

The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?

International Journal of Hypertension, 2012
It is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release. However, how the brain synthesizes angiotensin (Ang)
Wencheng Li, Hua Peng, Dale M. Seth, Yumei Feng   +3 more
doaj   +1 more source

Role of Nonclassical Renin-angiotensin system Axis In Renal Fibrosis

Frontiers in Physiology, 2015
The renin–angiotensin system (RAS) is a major regulator of renal fibrosis. Besides the classical renin/Angiotensin-converting enzyme 2 (ACE2)/angiotensin II (Ang II)/AT1 and AT2 axis, multiple new axes have been recently described.
Linli eLv, Bi-Cheng eLiu
doaj   +1 more source

Soluble (pro)renin receptor in elderly chronic heart failure patients

Frontiers in Bioscience-Landmark, 2020
Overactivation of renin-angiotensin system (RAS) is one of the main pathophysiological features in the evolution of chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player in a tissue renin-angiotensin system (tissue ...
Danilo Obradovic, Goran Loncar, Sara Radenovic, Elvis Tahirovic, Harald Heidecke, Kai Schulze-Forster, Dominik Muller, Andreas Busjahn, Petra Buttner, Jovan Veskovic, Marija Zdravkovic, Haluo Li, Simin Li, Vuk Savkovic, Burkert Pieske, Hans-Dirk Dungen, Ralf Dechend   +16 more
doaj   +1 more source

Peripheral blood mesenchymal stem cell‐derived exosomes improve renal sympathetic denervation efficacy through β‐catenin‐mediated cardiac reprogramming

Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.
Myocardial infarction triggers cardiomyocyte depletion and sympathetic overactivation, culminating in irreversible heart failure. Renal denervation (RD) attenuates sympathetic signalling, modulating catecholamine‒B‐type natriuretic peptide (BNP) homeostasis.
Lan Zhao, Chen Li, Zhichuan Huang, Jianshuo Wang, Zhanyu Deng, Yanwen Deng, Pengzhen Wang, Shaoheng Zhang   +7 more
wiley   +1 more source

Colocalization of the (Pro)renin Receptor/Atp6ap2 with H+-ATPases in Mouse Kidney but Prorenin Does Not Acutely Regulate Intercalated Cell H+-ATPase Activity.

PLoS ONE, 2016
The (Pro)renin receptor (P)RR/Atp6ap2 is a cell surface protein capable of binding and non-proteolytically activate prorenin. Additionally, (P)RR is associated with H(+)-ATPases and alternative functions in H(+)-ATPase regulation as well as in Wnt ...
Arezoo Daryadel, Soline Bourgeois, Marta F L Figueiredo, Ana Gomes Moreira, Nicole B Kampik, Lisa Oberli, Nilufar Mohebbi, Xifeng Lu, Marcel E Meima, A H Jan Danser, Carsten A Wagner   +10 more
doaj   +1 more source

The renal baroreflex: A systematic review and meta‐analysis in healthy and hypertensive animals

Physiological Reports, Volume 13, Issue 17, September 2025.
Abstract The renal baroreflex describes the dose‐dependent relation between renal pressure and renin release. Former studies have approximated this relation through animal experiments, but the exact shape of the response curve and its alteration by hypertension remain unclear.
Maaike van Ochten, Wisal El Fathi, Esmee M. E. Bovee, Marc E. A. Spaanderman, Carlijn R. Hooijmans, Joris van Drongelen   +5 more
wiley   +1 more source