Results 81 to 90 of about 1,765 (116)

Systematic review of ocular and circulatory cytokines linking diabetic retinopathy to kidney disease. [PDF]

Front Endocrinol (Lausanne)
Tang Y, Li Z, Jia Z.
europepmc   +1 more source

Structural and Computational Insights into the Angiotensin II Type 1 Receptor: Advances in Antagonist Design and Implications for Hypertension Therapy (2020-2024). [PDF]

Biomolecules
Chatzipieris FP, Petsas E, Lambrinidis G, Matsoukas JM, Mavromoustakos T.   +4 more
europepmc   +1 more source

Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies. [PDF]

Curr Hypertens Rep
Schofield LG, Endacott SK, Delforce SJ, Lumbers ER, Pringle KG.   +4 more
europepmc   +1 more source

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Acid-activated prorenin binds to (pro)renin receptor in vitro

Biochemical and Biophysical Research Communications, 2012
Binding properties of acid-activated prorenin to (pro)renin receptor [(P)RR] was investigated in vitro to discuss possible roles of such reversibly acid-activated prorenin in the renin angiotensin (RA) system. Prorenin was acidified at pH 3.3, 4.5, 5.5, 6.5, and its activation level was measured at 1, 2, 4, 8, 12, and 25 h.
A H M Nurun Nabi, Kazal Boron Biswas, Tsutomu Nakagawa   +2 more
exaly   +3 more sources

Trafficking of the Prorenin Receptor in Endothelial Cells

The FASEB Journal, 2020
Diabetic patients are at higher risk for hypertension and cardiovascular mortality than their normotensive, nondiabetic counterparts. Diabetic patients also have increased circulating prorenin which can bind to its receptor (PRR) to cause activation of the renin‐angiotensin system and ...
Nicholas R. Harris, Benard O. Ogola, Bruna Visniauskas, Prasad V. Katakam, Stryder M. Meadows, Minolfa C. Prieto, Sarah H. Lindsey   +6 more
openaire   +1 more source

Renin/prorenin-receptor biochemistry and functional significance

Current Hypertension Reports, 2004
The renin-angiotensin system (RAS) has become increasingly complex. New components have been identified, and additional roles for angiotensin peptides and their receptors are being uncovered. A functional (pro)renin receptor has been cloned that acts as (pro)renin cofactor on cell surface, enhancing the efficiency of angiotensinogen cleavage by (pro ...
Geneviève, Nguyen, Céline A, Burcklé, Jean-Daniel, Sraer   +2 more
openaire   +2 more sources

Prorenin receptor in kidney development

Pediatric Nephrology, 2016
Prorenin receptor (PRR), a receptor for renin and prorenin and an accessory subunit of the vacuolar proton pump H+-ATPase, is expressed in the developing kidney. Global loss of PRR is lethal in mice, and PRR mutations are associated with a high blood pressure, left ventricular hypertrophy and X-linked mental retardation in humans.
openaire   +2 more sources

Renin, Prorenin, and the (Pro)Renin Receptor

2009
The discovery of a receptor for renin and for its inactive precursor prorenin, and the introduction of renin inhibitors in therapeutic, has renewed the interest for the physiology of the renin angiotensin system (RAS) and has brought prorenin back in the spotlight.
Genevieve Nguyen, Aurelie Contrepas
openaire   +1 more source