Results 51 to 60 of about 3,903,665 (206)

Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts

Scientific Reports, 2021
The (pro)renin receptor (PRR) is a multifunctional integral membrane protein that serves as a component of the vacuolar H+-ATPase (V-ATPase) and also activates (pro)renin.
Jonathan B. Murray, Christy Mikhael, Guanghong Han, Lorraine Perciliano de Faria, Wellington J. Rody, L. Shannon Holliday   +5 more
doaj   +1 more source

Drug Discovery for Overcoming Chronic Kidney Disease (CKD): New Therapy for CKD by a (Pro)Renin-Receptor–Blocking Decoy Peptide

Journal of Pharmacological Sciences, 2009
Discovery of the (pro)renin receptor uncovered a novel function of renin/prorenin as the receptor ligands in addition to the enzyme and its precursor.
Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Hiroshi Itoh   +5 more
doaj   +1 more source

Sex‐specific associations of circulating soluble prorenin receptor with cardiometabolic risk factors among healthy women and men

The FASEB Journal, 2021
The prorenin receptor (PRR), a component of the renin angiotensin system, is involved in blood pressure control, fluid homeostasis, tissue development and vesicular trafficking and play an important role in cardiovascular diseases.
Frederique Yiannikouris, Gertrude Arthur, Lyndsey DuBose DuBose, Abbi Lane-Cordova Lane-cordova, Nicholas Jensen, Andrea Wehrle, Amy K. Stroud, G. Pierce   +7 more
semanticscholar   +1 more source

Renin, Prorenin and the Putative (Pro)renin Receptor [PDF]

Hypertension, 2005
Renin is an aspartic protease that consists of 2 homologous lobes. The cleft in between contains the active site with 2 catalytic aspartic residues.1 Unlike other aspartic proteases such as pepsin or cathepsin D, renin is monospecific and only cleaves angiotensinogen, to generate angiotensin (Ang) I.
Danser, A.H., Deinum, J.
openaire   +6 more sources

Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells.

PLoS ONE, 2014
UnlabelledChronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD). (Pro)renin receptor (PRR) is activated in the kidney of CKD.
Maimaiti Yisireyili, Shinichi Saito, Shaniya Abudureyimu, Yelixiati Adelibieke, Hwee-Yeong Ng, Fuyuhiko Nishijima, Kyosuke Takeshita, Toyoaki Murohara, Toshimitsu Niwa   +8 more
doaj   +1 more source

Scotty: lattice coincidences in the Protein Data Bank. [PDF]

Acta Crystallogr D Struct Biol
Scotty supports crystallographic comparisons of lattice coincidences, the interpretation of oligomeric assemblies and paracrystallinity.The application Scotty, implemented within the Phasertng codebase, was used to perform a PDB‐wide analysis of lattice coincidences.
McCoy AJ, Andrews LC, Bernstein HJ, Read RJ.   +3 more
europepmc   +2 more sources

Adrenal (Pro)renin Receptor Expression and Serum Soluble (Pro)renin Receptor Concentration in Primary Aldosteronism

International Journal of Endocrinology, 2020
The (pro)renin receptor [(P)RR] is a multifunctioning protein playing roles in various pathological conditions. A soluble form of (P)RR [s(P)RR] has been considered a biomarker for (P)RR expression in tissues.
Daisuke Watanabe, Satoshi Morimoto, Noriko Morishima, Yoichiro Kato, Yoji Nagashima, Noriyuki Shibata, Atsuhiro Ichihara   +6 more
doaj   +1 more source

Immunohistochemistry for (Pro)renin Receptor in Humans

International Journal of Endocrinology, 2021
The (pro)renin receptor is a multifunctional protein with roles in angiotensin-II-dependent and -independent intracellular cell signaling and roles as an intracellular accessory protein for the vacuolar H+-ATPase, including hormone secretion.
Satoshi Morimoto, Noriko Morishima, Daisuke Watanabe, Yoichiro Kato, Noriyuki Shibata, Atsuhiro Ichihara   +5 more
doaj   +1 more source

Prorenin, Renin, and Their Receptor [PDF]

Hypertension, 2010
In addition to its well-known role in regulating blood pressure and fluid balance, the renin-angiotensin-aldosterone system (RAAS) has continued to fascinate both researchers and clinicians because of the several additional functions that it has been proposed to carry out.
openaire   +2 more sources

Placental deficiency of the (pro)renin receptor ((P)RR) reduces placental development and functional capacity

Frontiers in Cell and Developmental Biology, 2023
The (pro)renin receptor ((P)RR; also known as ATP6AP2) is a multifunctional receptor. The (P)RR activates the tissue renin-angiotensin system (RAS) and is also involved in regulating integral intracellular pathways such as V-ATPase and Wnt/β-catenin ...
Lachlan G. Schofield, Lachlan G. Schofield, Richard G. S. Kahl, Richard G. S. Kahl, Samantha L. Rodrigues, Samantha L. Rodrigues, Joshua J. Fisher, Joshua J. Fisher, Saije K. Endacott, Saije K. Endacott, Sarah J. Delforce, Sarah J. Delforce, Eugenie R. Lumbers, Eugenie R. Lumbers, Jacinta H. Martin, Jacinta H. Martin, Kirsty G. Pringle, Kirsty G. Pringle   +17 more
doaj   +1 more source