Results 41 to 50 of about 3,425 (209)

A Benign Renal Tumor With Serious Consequences: A Case Report of Juxtaglomerular Cell Tumor and Chronic Renal Disease in a Teenager. [PDF]

Case Rep Pediatr
Juxtaglomerular cell tumor (JGCT), or reninoma, is a rare benign renal neoplasm. It is characterized by severe hypertension and hypokalemia due to excessive renin produced from the juxtaglomerular apparatus on the afferent arteriole of the glomerulus. Herein, we report a case of JGCT in a 15‐year‐old female who presented with severe hypertension.
Courtney R, Dahlinghaus E, Omoloja A, Boyd JT, Smith M, Biederman L, Ndengabaganizi I, Robie DK, Al Dughiem A.   +8 more
europepmc   +2 more sources

Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microglia.

PLoS ONE, 2019
Accumulating evidence suggests that neuroinflammation and oxidative stress in cardiovascular center contribute to the pathological processes underlying hypertension. Microglia activation triggers the inflammation and oxidative stress.
Li Hu, Shutian Zhang, Haoyu Wen, Tianfeng Liu, Jian Cai, Dongshu Du, Danian Zhu, Fuxue Chen, Chunmei Xia   +8 more
doaj   +1 more source

Proteinic prorenin-releasing-stimulator (PRS) in the rat submandibular gland [PDF]

, 1989
The release of prorenin as well as renin from rat renal slices was confirmed by a rat prorenin-prosegment ELISA system and an assay system for determining the renin activity.
Yukio Nakamura, Suzuki, Fumiaki, Yamashita, Shinji, Murakami, Kazuo, Okamoto, Naoko, Masanobu Uozumi, Fumiaki Suzuki, Sciji Miyazaki, Kazuo Murakami, Miyazaki, Sciji, Naoko Okamoto, Shinji Yamashita, Uozumi, Masanobu, Nakamura, Yukio   +13 more
core   +1 more source

Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II [PDF]

, 2002
Cardiomyocytes bind, internalize, and activate prorenin, the inactive precursor of renin, via a mannose 6-phosphate receptor (M6PR)--dependent mechanism. M6PRs couple directly to G-proteins. To investigate whether prorenin binding to
van den Eijnden, MMED (Mark), Schalekamp, M.A.D.H. (Maarten), Mark M.E.D. van den Eijnden, Saris, J.J. (Jasper), Saris, Jasper; id_orcid, Jasper J. Saris, Maarten A.D.H. Schalekamp, Schalekamp, MADH (Maarten), Danser, A.H.J. (Jan), Saris, Jasper, Danser, Jan, Lamers, J.M.J. (Jos), Jos M.J. Lamers, A.H. Jan Danser, Pramod R. Saxena, Saxena, Pramod, Eijnden, M.M.E.D. (Mark) van den, Saxena, P.R. (Pramod Ranjan), Lamers, Jos   +18 more
core   +2 more sources

Megalin A Novel Endocytic Receptor for Prorenin and Renin [PDF]

, 2020
Megalin is an endocytic receptor contributing to protein reabsorption. Impaired expression or trafficking of megalin increases urinary renin and allowed the detection of prorenin, which normally is absent in urine. Here, we investigated (pro)renin uptake
Sun, Yuan, Masereeuw, R, Van den Berg - Garrelds, Ingrid; id_orcid, Goes Martini, Alexandre, Masereeuw, Rosalinde, Janssen, MJC, Martini, Alexandre, Janssen, Manoe J., Garrelds, Ingrid M., Lu, Xifeng, Van den Berg - Garrelds, Ingrid, Danser, A. H.Jan, Danser, AHJ, Lu, XF   +13 more
core   +1 more source

Direct pro-inflammatory effects of prorenin on microglia.

PLoS ONE, 2014
Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of the ...
Peng Shi, Justin L Grobe, Fiona A Desland, Guannan Zhou, Xiao Z Shen, Zhiying Shan, Meng Liu, Mohan K Raizada, Colin Sumners   +8 more
doaj   +1 more source

Interaction between nuclear‐translocated cellular communication network factor 2 and purine‐rich box 1 regulates the expression of fibrosis‐related genes

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Although cellular communication network factor 2 (CCN2) is secreted out to the extracellular environment, intracellular CCN2 rather than re‐incorporated CCN2 from the outside may be involved in its translocation into the nuclei, because translocation of CCN2 into the nucleus was not disturbed by soluble heparin.
Xuan Thi Nguyen, Satoshi Kubota, Masaharu Takigawa, Takashi Nishida   +3 more
wiley   +1 more source

A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation

Molecular Therapy: Nucleic Acids, 2017
The receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to the (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling.
Atsuhiro Kanda, Erdal Tan Ishizuka, Atsushi Shibata, Takahiro Matsumoto, Hidekazu Toyofuku, Kousuke Noda, Kenichi Namba, Susumu Ishida   +7 more
doaj   +1 more source

Sex differences in soluble prorenin receptor in patients with type 2 diabetes

Biology of Sex Differences, 2021
Background The soluble prorenin receptor (sPRR), a member of the renin-angiotensin system (RAS), is elevated in plasma of patients with preeclampsia, hypertension, chronic kidney disease (CKD), and type 2 diabetes.
Bruna Visniauskas, Danielle Y. Arita, Carla B. Rosales, Mohammed A. Feroz, Christina Luffman, Michael J. Accavitti, Gabrielle Dawkins, Jennifer Hong, Andrew C. Curnow, Tina K. Thethi, John J. Lefante, Edgar A. Jaimes, Franck Mauvais-Jarvis, Vivian A. Fonseca, Minolfa C. Prieto   +14 more
doaj   +1 more source

Peripheral blood mesenchymal stem cell‐derived exosomes improve renal sympathetic denervation efficacy through β‐catenin‐mediated cardiac reprogramming

Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.
Myocardial infarction triggers cardiomyocyte depletion and sympathetic overactivation, culminating in irreversible heart failure. Renal denervation (RD) attenuates sympathetic signalling, modulating catecholamine‒B‐type natriuretic peptide (BNP) homeostasis.
Lan Zhao, Chen Li, Zhichuan Huang, Jianshuo Wang, Zhanyu Deng, Yanwen Deng, Pengzhen Wang, Shaoheng Zhang   +7 more
wiley   +1 more source