Results 21 to 30 of about 3,425 (209)

Differential Roles of Angiotensin A and Alamandine in Parkinson's Disease: A Therapeutic Perspective on Nonclassical RAS Pathways. [PDF]

Brain Behav
The role of the Classical and Non‐Classical RAS pathway in Parkinson's disease: Pathogenesis and Therapeutic strategies. PD, Parkinson's disease; DNs, Dopaminergic neurons; SN, Substantia Nigra; α‐syn, alpha‐synuclein; RAS, renin‐angiotensin system; Ang II, Angiotensin II; AT1R, Angiotensin II type 1 Receptor; ACE2, angiotensin‐converting enzyme 2; Ang
Alshehri GH, Al-Kuraishy HM, Albuhadily AK, Al-Gareeb AI, Aboutaleb AS, Alexiou A, Papadakis M, Batiha GE.   +7 more
europepmc   +2 more sources

Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

Reproductive Biology and Endocrinology, 2021
Background Pregnancies with > 1 corpus luteum (CL) display a hyperdynamic circulation and an increased risk of small-for-gestational age deliveries. Among the factors released by the CL is prorenin, the inactive precursor of renin.
Rosalieke E. Wiegel, Maud J. H. Karsten, Igna F. Reijnders, Lenie van Rossem, Sten P. Willemsen, Annemarie G. M. G. J. Mulders, Anton H. J. Koning, Eric A. P. Steegers, A. H. Jan Danser, Régine P. M. Steegers-Theunissen   +9 more
doaj   +1 more source

Increased Prorenin Expression in the Kidneys May Be Involved in the Abnormal Renal Function Caused by Prolonged Environmental Exposure to Microcystin-LR. [PDF]

Toxics
Toxic algae in eutrophic lakes produce cyanotoxic microcystins. Prior research on the effect of microcystin-LR in the kidney utilized intraperitoneal injections, which did not reflect natural exposure.
Hitsuda Y, Koto Y, Kawahara H, Kurata K, Yoshikiyo K, Nishimura K, Hashiguchi A, Maseda H, Okano K, Sugiura N, Shimizu K, Shimizu H.   +11 more
europepmc   +2 more sources

Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy. [PDF]

PLoS ONE, 2017
(Pro)renin receptor [(P)RR], a new component of the tissue renin-angiotensin system (RAS), plays a crucial role in inflammation and angiogenesis in the eye, thus contributing to the development of proliferative diabetic retinopathy (PDR).
Keitaro Hase, Atsuhiro Kanda, Ikuyo Hirose, Kousuke Noda, Susumu Ishida   +4 more
doaj   +1 more source

RAAS in diabetic retinopathy: mechanisms and therapies. [PDF]

Arch Endocrinol Metab
Diabetic retinopathy (DR) is a complication of diabetes with a complex pathophysiology and multiple factors involved. Recently, it has been found that the upregulation of the renin-angiotensin-aldosterone system (RAAS) leads to overexpression of ...
Li X, Fu YH, Tong XW, Zhang YT, Shan YY, Xu YX, Pu SD, Gao XY.   +7 more
europepmc   +2 more sources

High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. [PDF]

PLoS ONE, 2015
It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake.
Yuka Hayakawa, Takuma Aoyama, Chiharu Yokoyama, Chihiro Okamoto, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Itta Kawamura, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Fumiaki Suzuki, Shinya Minatoguchi   +13 more
doaj   +1 more source

Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells.

PLoS ONE, 2014
UnlabelledChronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD). (Pro)renin receptor (PRR) is activated in the kidney of CKD.
Maimaiti Yisireyili, Shinichi Saito, Shaniya Abudureyimu, Yelixiati Adelibieke, Hwee-Yeong Ng, Fuyuhiko Nishijima, Kyosuke Takeshita, Toyoaki Murohara, Toshimitsu Niwa   +8 more
doaj   +1 more source

The Role of Angiotensin-II Infusion in an Infant With Autosomal Recessive Polycystic Kidney Disease Postbilateral Nephrectomies and Refractory Hypotension in the Neonatal Period. [PDF]

Case Rep Nephrol
Autosomal recessive polycystic kidney disease (ARPKD) is a form of hereditary cystic disease with a highly variable phenotypic expression that ultimately leads to chronic kidney disease. Severe cases may warrant surgical intervention with unilateral or bilateral nephrectomy to alleviate thoracic and abdominal compression from massive nephromegaly ...
Nevarez Gilbert A, Rahde Bischoff A, Merrill K.   +2 more
europepmc   +2 more sources

Drug Discovery for Overcoming Chronic Kidney Disease (CKD): New Therapy for CKD by a (Pro)Renin-Receptor–Blocking Decoy Peptide

Journal of Pharmacological Sciences, 2009
Discovery of the (pro)renin receptor uncovered a novel function of renin/prorenin as the receptor ligands in addition to the enzyme and its precursor.
Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Hiroshi Itoh   +5 more
doaj   +1 more source

Role of Nonclassical Renin-angiotensin system Axis In Renal Fibrosis

Frontiers in Physiology, 2015
The renin–angiotensin system (RAS) is a major regulator of renal fibrosis. Besides the classical renin/Angiotensin-converting enzyme 2 (ACE2)/angiotensin II (Ang II)/AT1 and AT2 axis, multiple new axes have been recently described.
Linli eLv, Bi-Cheng eLiu
doaj   +1 more source