Results 31 to 40 of about 3,425 (209)

High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct

Scientific Reports, 2021
Growing evidence indicates that prorenin receptor (PRR) is upregulated in collecting duct (CD) of diabetic kidney. Prorenin is secreted by the principal CD cells, and is the natural ligand of the PRR. PRR activation stimulates fibrotic factors, including
Venkateswara R. Gogulamudi, Danielle Y. Arita, Camille R. T. Bourgeois, Justine Jorgensen, Jing He, William C. Wimley, Ryosuke Satou, Alexis A. Gonzalez, Minolfa C. Prieto   +8 more
doaj   +1 more source

Renin-a in the Subfornical Organ Plays a Critical Role in the Maintenance of Salt-Sensitive Hypertension

Biomolecules, 2022
The brain renin-angiotensin system plays important roles in blood pressure and cardiovascular regulation. There are two isoforms of prorenin in the brain: the classic secreted form (prorenin/sREN) encoded by renin-a, and an intracellular form (icREN ...
Silvana G. Cooper, Lucas A. C. Souza, Caleb J. Worker, Ariana Julia B. Gayban, Sophie Buller, Ryosuke Satou, Yumei Feng Earley   +6 more
doaj   +1 more source

Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock

Critical Care, 2023
Background Sepsis-induced endothelial dysfunction is proposed to cause angiotensin-converting enzyme (ACE) dysfunction and renin–angiotensin–aldosterone system (RAAS) derangement, exacerbating vasodilatory shock and acute kidney injury (AKI). Few studies
Naomi Pode-Shakked, Giovanni Ceschia, James E. Rose, Stuart L. Goldstein, Natalja L. Stanski, the Genomics of Pediatric Septic Shock Investigators   +5 more
doaj   +1 more source

Planning of optimization of prorenin peptide vaccine.

, 2022
(A) Tertiary structure of prorenin. Prorenin consists of the prosegment (blue and red) and mature renin (white). (B) Antigen E1 and E2 contained the handle region, but E3 did not. (C) Schedule for vaccination and antibody titer measurement.
Taiji Nagaoka (11965174), Junya Hanaguri (11965171), Satoru Yamagami (42035), Hironori Nakagami (170253), Harumasa Yokota (11965168), Hiroki Hayashi (807915), Akifumi Kushiyama (748918)   +6 more
core   +1 more source

First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort

Hypertension in Pregnancy, 2023
Objective To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI.
D. Aoulad Fares, R.E. Wiegel, A.J. Eggink, J.B.J. van Meurs, S.P. Willemsen, A.H.J. Danser, R.P.M. Steegers-Theunissen   +6 more
doaj   +1 more source

Prorenin and diabetes mellitus [PDF]

, 1993
The renin-angiotensin system (RAS) plays an important role in the regulation of arterial blood pressure and water and salt regulation. Until recently this system was considered to be exclusively a circulating endocrine system. Circulating renin, released
Franken, A.A.M. (Anton)
core   +1 more source

GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions. [PDF]

Biol Res
Background During diabetes, prorenin is highly produced by the renal collecting ducts. The binding of prorenin to (pro)renin receptor (PRR) on the apical plasma membrane triggers intracellular profibrotic genes, including TGF-β and CTGF.
Larenas PE, Cárdenas P, Aguirre-Delgadillo M, Moris C, Casarini DE, Vallotton Z, Prieto MC, Gonzalez AA.   +7 more
europepmc   +2 more sources

Combined renin inhibition/(pro)renin receptor blockade in diabetic retinopathy--a study in transgenic (mREN2)27 rats.

PLoS ONE, 2014
Dysfunction of renin-angiotensin system (RAS) contributes to the pathogenesis of diabetic retinopathy (DR). Prorenin, the precursor of renin is highly elevated in ocular fluid of diabetic patients with proliferative retinopathy.
Wendy W Batenburg, Amrisha Verma, Yunyang Wang, Ping Zhu, Mieke van den Heuvel, Richard van Veghel, A H Jan Danser, Qiuhong Li   +7 more
doaj   +1 more source

Recent Advances in Soluble Prorenin Receptor in Multisystem Diseases [PDF]

Zhongguo quanke yixue
Previous studies on renin-angiotensin-aldosterone system (RAAS) mainly focus on renin, prorenin and prorenin receptor (PRR), which play an important role in cardiovascular, renal and other diseases.
LI Mengye, JIANG Yinong
doaj   +1 more source

Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts

Scientific Reports, 2021
The (pro)renin receptor (PRR) is a multifunctional integral membrane protein that serves as a component of the vacuolar H+-ATPase (V-ATPase) and also activates (pro)renin.
Jonathan B. Murray, Christy Mikhael, Guanghong Han, Lorraine Perciliano de Faria, Wellington J. Rody, L. Shannon Holliday   +5 more
doaj   +1 more source