Results 51 to 60 of about 3,425 (209)
Immunohistochemistry of renin/prorenin in rat aorta.
, 2014 A. Immonohistochemical localization of renin/prorenin in the aortas of normal, CKD and AST-120-treated CKD rats. B. Quantitative data of renin/prorenin-positive area in the aortas of normal (n = 9), CKD (n = 8) and AST-120-treated CKD rats (n = 8) (Mean ...
Shaniya Abudureyimu (649239) +8 more
core +1 more source
Acute, pro‐contractile effects of prorenin on rat mesenteric arteries
, 2023 Prorenin and the prorenin receptor ((P)RR) are important, yet controversial, members of the renin–angiotensin–aldosterone system. The ((P)RR) is expressed throughout the body, including the vasculature, however, the direct effect of prorenin on arterial ...
Greenstein, Adam; id_orcid +8 more
core +1 more source
Journal of Diabetes Investigation, 2019 The renin–angiotensin system (RAS), a crucial regulator of systemic blood pressure (circulatory RAS), plays distinct roles in pathological angiogenesis and inflammation in various organs (tissue RAS), such as diabetic microvascular complications.
Atsuhiro Kanda, Susumu Ishida
doaj +1 more source
(Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells. [PDF]
PLoS ONE, 2013 The binding of renin or prorenin to the (pro)renin receptor (PRR) promotes angiotensin (Ang) II formation and mediates Ang II-independent signaling pathways.
Hua Peng +5 more
doaj +1 more source
PLoS ONE, 2016 The (Pro)renin receptor (P)RR/Atp6ap2 is a cell surface protein capable of binding and non-proteolytically activate prorenin. Additionally, (P)RR is associated with H(+)-ATPases and alternative functions in H(+)-ATPase regulation as well as in Wnt ...
Arezoo Daryadel +10 more
doaj +1 more source
Physiological Reports, Volume 13, Issue 17, September 2025.Abstract This study was conducted to examine the ontogeny of and interactions between the thyroid system and local renin‐angiotensin systems (RAS) in the porcine fetus. N = 24 pregnant gilts were split into two groups, receiving either a daily dose of methimazole to induce fetal hypothyroidism, or a daily sham control. Within each group, treatment of n
Alyssa A. Smith, J. Alex Pasternak
wiley +1 more source
Activation and function of prorenin: different viewpoints
, 1991 This Symposium includes 15 presentations and an editorial review dealing with prorenin activation and function. It comes 20 years after prorenin was first reported in various contexts and attracted attention because of its connection with renin ...
J. E. Sealey +2 more
core +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2016 Akihiro Tojo,1 Satoshi Kinugasa,1 Toshiro Fujita,2 Christopher S Wilcox3 1Division of Nephrology and Endocrinology, 2Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan; 3Division of Nephrology and Hypertension ...
Tojo A, Kinugasa S, Fujita T, Wilcox CS
doaj
Molecular Therapy: Nucleic Acids, 2019 The receptor-associated prorenin system refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent signaling, and its activation contributes to
Ye Liu +7 more
doaj +1 more source
Trypsin activation of human and cat prorenin: a comparative study.
, 1991 Prorenin can be converted to renin by limited proteolysis with trypsin. In the current study we compared conditions for activation of human renal and ovarian prorenin and cat renal prorenin with either liquid-phase trypsin or trypsin bound to sepharose (
Speranza Rubattu +5 more
core +1 more source