Results 71 to 80 of about 3,425 (209)

Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway

Frontiers in Physiology, 2021
Emerging evidence is showing that apelin plays an important role in regulating salt and water balance by counteracting the antidiuretic action of vasopressin (AVP). However, the underlying mechanism remains unknown. Here, we hypothesized that (pro) renin
Yanting Chen, Chuanming Xu, Chuanming Xu, Jiajia Hu, Mokan Deng, Qixiang Qiu, Shiqi Mo, Yanhua Du, Tianxin Yang   +8 more
doaj   +1 more source

Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the prorenin receptor

, 2011
The discovery of a specific prorenin receptor has opened to a possible biological function of prorenin independently from angiotensin I production. In the present study we show that prorenin receptor is expressed in normal human vessels (mammary arteries
C. M. Greco, M.L. Gelmi, N. Ferri, M. Camera, L. Facchinetti, A. Corsini, E. Tremoli, M. Brambilla, S. Pellegrino   +8 more
core   +1 more source

Wnt signalosomes: What we know that we do not know

BioEssays, Volume 47, Issue 2, February 2025.
Wnt signaling occurs through a “signalosome” receptor complex, driven by oligomerization of the adaptor, Disheveled (Dvl). Both endocytosis and condensate formation have been proposed to mediate signalosome formation. Under pathological conditions, signalosomes may form in a Wnt ligand‐independent manner.
Heather Hartmann, Ghalia Saad Siddiqui, Jamal Bryant, David J. Robbins, Vivian L. Weiss, Yashi Ahmed, Ethan Lee   +6 more
wiley   +1 more source

Prorenin secretion from human placenta perfused in vitro

, 1991
We examined whether renin (prorenin plus renin) is secreted from the human placenta into the maternal or fetal circulation and compared the secretion rate to that of human chorionic gonadotropin (hCG), progesterone, and estradiol.
G. D. James, J. E. Sealey, T. Lenz, J. H. Laragh   +3 more
core   +1 more source

Phosphoproteomics for studying signaling pathways evoked by hormones of the renin‐angiotensin system: A source of untapped potential

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract The Renin‐Angiotensin System (RAS) is a complex neuroendocrine system consisting of a single precursor protein, angiotensinogen (AGT), which is processed into various peptide hormones, including the angiotensins [Ang I, Ang II, Ang III, Ang IV, Ang‐(1–9), Ang‐(1–7), Ang‐(1–5), etc] and Alamandine‐related peptides [Ang A, Alamandine, Ala‐(1–5)],
Igor Maciel Souza‐Silva, Victor Corasolla Carregari, U. Muscha Steckelings, Thiago Verano‐Braga   +3 more
wiley   +1 more source

DEXAMETHASONE-INHIBITABLE STIMULATION OF PLASMA PRORENIN BY KETAMINE IN CATS

, 1989
Plasma prorenin in humans is derived from both renal and extrarenal sources, but in the cat most plasma prorenin is normally of renal origin. Sodium depletion and β-adrenergic blockade can increase plasma prorenin in cats, but the effects of sedatives ...
M. Peterson, J. E. Sealey, RUBATTU, Speranza Donatella, D. N. Marion   +3 more
core   +1 more source

Renin-angiotensin-aldosteron system: evolution of views from renin discovery to nowadays. Perspectives of therapeutic block

Терапевтический архив, 2011
Recent revolution in the knowledge about structure, physiological and pathophysiological effects of renin-angiotensin-aldosteron system (RAAS) took place recently when it was discovered that local synthesis of all the RAAS components occurs in target ...
Marina Vladimirovna Shestakova, M V Shestakova   +1 more
doaj  

Increased plasma prorenin but not renin after bilateral ureteral ligation in dogs [PDF]

, 1991
Increased plasma prorenin but not renin after bilateral ureteral ligation in dogs. Plasma prorenin is normally higher than renin and usually changes in response to the same stimuli. In dogs, plasma prorenin and renin disappear after bilateral nephrectomy,
Gulmi, Frederick, von Lutterotti, Nicola, Vaughan, E. Darrocott, Sealey, Jean E., Laragh, John H., Marion, Donald   +5 more
core   +1 more source

Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. [PDF]

PLoS ONE, 2013
The role of the prorenin receptor (PRR) in the regulation of ureteric bud (UB) branching morphogenesis is unknown. Here, we investigated whether PRR acts specifically in the UB to regulate UB branching, kidney development and function.
Renfang Song, Graeme Preston, Atsuhiro Ichihara, Ihor V Yosypiv   +3 more
doaj   +1 more source

Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors [PDF]

, 2001
ACE inhibitors improve endothelial dysfunction, possibly by blocking endothelial angiotensin production. Prorenin, through its binding and activation by endothelial mannose 6-phosphate (M6P) receptors, may contribute to ...
van den Eijnden, MMED (Mark), Reudelhuber, T.L., Schalekamp, M.A.D.H. (Maarten), Derkx, F.H.M. (Frans), Saris, J.J. (Jasper), Saris, Jasper; id_orcid, Sluiter, W. (Wim), Sluiter, Wim, Schalekamp, MADH (Maarten), Bruin, R.J.A. (René) de, Danser, A.H.J. (Jan), Saris, Jasper, Wit, E. (Emmie) de, Danser, Jan, Bruin, Rene, de Wit, E (Emmie), Reudelhuber, TL, Derkx, FHM, Eijnden, M.M.E.D. (Mark) van den   +18 more
core   +2 more sources