Results 91 to 100 of about 3,425 (209)

Vacuolar H+‐ATPase in Diabetes, Hypertension, and Atherosclerosis

Microcirculation, Volume 31, Issue 5, July 2024.
ABSTRACT Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It acts as a proton pump and as such is responsible for regulating pH in lysosomes, endosomes, and the extracellular space.
Na Wang, Liwei Ren, A. H. Jan Danser
wiley   +1 more source

REVERSIBLE CRYOACTIVATION OF RECOMBINANT HUMAN PRORENIN

, 1992
Cleavage of prorenin's prosegment causes irreversible formation of renin. In contrast, renin activity is reversibly exposed when prorenin is acidified to pH 3.3. Nonetheless, acidification of plasma results in irreversible activation of prorenin, because
J. E. Sealey, RUBATTU, Speranza Donatella, R. Heinrikson, T. M. Pitarresi   +3 more
core  

Activation and measurement of plasma prorenin in the rat

, 1991
Prorenin determination in rat plasma has been problematic from the outset. Consequently, its existence is questioned by some and its quantity by others, making it difficult for knowledge to advance as to its function relative to the renin system.
A. Y. Loh, D. H. Osmond, P. Ioannou
core   +1 more source

Aliskiren inhibits prorenin-induced human aortic smooth muscle cell migration [PDF]

, 2015
Background: In the present study, we investigated the potential effect of aliskiren on smooth muscle cell (SMC) migration in response to prorenin.
FERRI, NICOLA, Maiocchi, Giuseppe, Panariti, Federica, Ricci, Chiara, Corsini, Alberto   +4 more
core   +1 more source

The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesis.

PLoS ONE, 2013
The ATPase 6 accessory protein 2 (ATP6AP2)/(pro)renin receptor (PRR) is essential for the biogenesis of active vacuolar H(+)-ATPase (V-ATPase). Genetic deletion of ATP6AP2/PRR causes V-ATPase dysfunction and compromises vesicular acidification.
Kenichiro Kinouchi, Atsuhiro Ichihara, Motoaki Sano, Ge-Hong Sun-Wada, Yoh Wada, Hiroki Ochi, Toru Fukuda, Kanako Bokuda, Hideaki Kurosawa, Naohiro Yoshida, Shu Takeda, Keiichi Fukuda, Hiroshi Itoh   +12 more
doaj   +1 more source

Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats

Frontiers in Pharmacology, 2019
In angiotensin II (Ang II)-dependent hypertensive rats there is an increased expression of proximal tubule angiotensinogen (AGT), collecting duct renin and angiotensin converting enzyme (ACE), which contributes to intratubular Ang II formation.
Alexis A. Gonzalez, Matias Gallardo, Carlos Cespedes, Carlos Cespedes, Carlos P. Vio, Carlos P. Vio   +5 more
doaj   +1 more source

Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor

, 2007
OBJECTIVE: Mannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such binding contributes to renin/prorenin clearance but not to angiotensin generation. Here, we evaluated the kinetics of renin/prorenin binding to the recently discovered
Burckle, C.A., Nguyen, G., Batenburg, W.W., Danser, A.H.J., Krop, M., Garrelds, I.M., de Bruin, R.J.A., Mueller, D.N., de Vries, R., Bader, M.   +9 more
core   +1 more source

Prorenin receptor is critical for nephron progenitors

Developmental Biology, 2016
Deficient nephrogenesis is the major factor contributing to renal hypoplasia defined as abnormally small kidneys. Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells of the cap mesenchyme (CM) and the ureteric bud (UB).
Song, Renfang, Preston, Graeme, Kidd, Laura, Bushnell, Daniel, Sims-Lucas, Sunder, Bates, Carlton M., Yosypiv, Ihor V.   +6 more
openaire   +2 more sources

Prorenin Receptor Is Essential for Normal Podocyte Structure and Function

, 2011
The prorenin receptor is an accessory subunit of the vacuolar H(+)-ATPase, suggesting that it has fundamental functions beyond activation of the local renin-angiotensin system.
Takemoto, M, Yoichi Oshima, Taketo Yamada, Susan E. Quaggin, Asako Kurauchi-Mito, Hiroshi Itoh, Tatsuya Narita, Oshima, Y, Kurosawa, H, Ichihara, A, Quaggin, SE, Ge-Hong Sun-Wada, Yamada, T, Mariyo Sakoda, Kenichiro Kinouchi, Bokuda, K, Itoh, H, Yoh Wada, Saleem, MA, Moin A. Saleem, Atsuhiro Ichihara, Minoru Takemoto, Narita, T, Wada, Y, Kinouchi, K, Sun-Wada, GH, Kanako Bokuda, Hideaki Kurosawa, Kurauchi-Mito, A, Sakoda, M   +29 more
core   +1 more source

Purification of functional baculovirus particles from silkworm larval hemolymph and their use as nanoparticles for the detection of human prorenin receptor (PRR) binding

BMC Biotechnology, 2011
Background Baculovirus, which has a width of 40 nm and a length of 250-300 nm, can display functional peptides, receptors and antigens on its surface by their fusion with a baculovirus envelop protein, GP64.
Park Enoch Y, Suzuki Fumiaki, Kato Tatsuya   +2 more
doaj   +1 more source