Results 101 to 110 of about 3,425 (209)
Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control
Molecular Metabolism, 2016 Background: Hypertension and obesity are highly interrelated diseases, being critical components of the metabolic syndrome. Despite the growing prevalence of this syndrome in the world population, efficient therapies are still missing.
Soledad Pitra +2 more
doaj +1 more source
118. THE PRORENIN RECEPTOR/PLZF PATHWAY IN HUMAN AMNION
, 2010 Prorenin, despite being inactive, is the major form of renin found in amniotic fluid and reproductive tissues. Prorenin becomes active if it binds to the novel prorenin receptor (ATP6AP2).
A. L. Conquest +4 more
core +1 more source
Two-step prorenin-renin conversion. Isolation of an intermediary form of activated prorenin.
Journal of Biological Chemistry, 1987 Prorenin is an inactive form of the aspartic protease renin. Like pepsinogen, it is activated at low pH. The kinetics of acid activation of prorenin were studied in human amniotic fluid and plasma and in preparations of purified prorenin isolated from amniotic fluid and plasma. Conversion of prorenin (pR) into active renin (R) appeared to be a two-step
F H, Derkx +2 more
openaire +2 more sources
Ang II, prorenin, and renin levels in Neuro-2A cells.
, 2013 Ang II levels in cell lysate (A) and cell culture medium (B) following treatment of vehicle or mouse prorenin (0.1, 1, 2, and 10 nM; 20 min), with or without captopril (10 µM; 30 min) 3 d after virus infection.
Joseph Francis (293028) +5 more
core +1 more source
Plasma Soluble (Pro)renin Receptor Reflects Renal Damage.
PLoS ONE, 2016 Background(Pro)renin receptor [(P)RR], a specific receptor for renin and prorenin, was identified as a member of the renin-angiotensin system (RAS). (P)RR is cleaved by furin, and soluble (P)RR [s(P)RR] is secreted into the extracellular space.
Naro Ohashi +13 more
doaj +1 more source
Plasma kallikrein and prorenin in patients with hereditary angioedema
, 1985 Recent evidence indicates that plasma kallikrein is activated during acute attacks of hereditary angioedema. Plasma kallikrein is known to convert inactive renin, or prorenin, into an active proteolytic enzyme in plasma exposed to acid or low ...
Schapira, M. +3 more
core +1 more source
(Pro)renin Receptor in Kidney Development and Disease
International Journal of Nephrology, 2011 The renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. All the components of the RAS are expressed in the developing metanephros.
Renfang Song, Ihor V. Yosypiv
doaj +1 more source
NFκB activation mediated prorenin-induced cytokine production.
, 2014 (A) N-9 (i–ii) and primary microglial cells (iii–iv) were treated with prorenin (10–50 nmol/L), and cell lysates were analyzed by real-time RT-PCR for NFκB1 and NFκBia.
Xiao Z. Shen (642848) +8 more
core +1 more source
, 1987 Standard methods for determining prorenin-renin concentrations in plasma (PRC) and other tissues require the addition of exogenous renin substrate (angiotensinogen) to improve the kinetics of the renin reaction.
Daniel H. Osmond +2 more
core +1 more source
Cardiomyocytes bind and activate native human prorenin : role of soluble mannose 6-phosphate receptors [PDF]
, 2001 Cardiomyocytes bind, internalize, and activate recombinant human prorenin through mannose 6-phosphate/insulin-like growth factor II (M6P/IGFII) receptors. To investigate whether this also applies to native human prorenin,
Lamers, J.M.J. (Jos) +5 more
core +2 more sources