Results 61 to 70 of about 3,425 (209)

Upregulation of the Renin–Angiotensin System Is Associated with Patient Survival and the Tumour Microenvironment in Glioblastoma

Cells
Glioblastoma is a highly aggressive disease with poor survival outcomes. An emerging body of literature links the role of the renin–angiotensin system (RAS), well-known for its function in the cardiovascular system, to the progression of cancers.
Mathew Lozinski, Eugenie R. Lumbers, Nikola A. Bowden, Jennifer H. Martin, Michael F. Fay, Kirsty G. Pringle, Paul A. Tooney   +6 more
doaj   +1 more source

(Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells

Frontiers in Pharmacology, 2019
The binding of prorenin to the (pro)renin receptor (PRR) triggers the activation of MAPK/ERK1/2 pathway, induction of cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), and the induction of transforming growth factor β
Cristian Reyes-Martinez, Quynh My Nguyen, Modar Kassan, Alexis A. Gonzalez   +3 more
doaj   +1 more source

Immunohistochemistry for (Pro)renin Receptor in Humans

International Journal of Endocrinology, 2021
The (pro)renin receptor is a multifunctional protein with roles in angiotensin-II-dependent and -independent intracellular cell signaling and roles as an intracellular accessory protein for the vacuolar H+-ATPase, including hormone secretion.
Satoshi Morimoto, Noriko Morishima, Daisuke Watanabe, Yoichiro Kato, Noriyuki Shibata, Atsuhiro Ichihara   +5 more
doaj   +1 more source

Placental deficiency of the (pro)renin receptor ((P)RR) reduces placental development and functional capacity

Frontiers in Cell and Developmental Biology, 2023
The (pro)renin receptor ((P)RR; also known as ATP6AP2) is a multifunctional receptor. The (P)RR activates the tissue renin-angiotensin system (RAS) and is also involved in regulating integral intracellular pathways such as V-ATPase and Wnt/β-catenin ...
Lachlan G. Schofield, Lachlan G. Schofield, Richard G. S. Kahl, Richard G. S. Kahl, Samantha L. Rodrigues, Samantha L. Rodrigues, Joshua J. Fisher, Joshua J. Fisher, Saije K. Endacott, Saije K. Endacott, Sarah J. Delforce, Sarah J. Delforce, Eugenie R. Lumbers, Eugenie R. Lumbers, Jacinta H. Martin, Jacinta H. Martin, Kirsty G. Pringle, Kirsty G. Pringle   +17 more
doaj   +1 more source

Preascitic Sodium Retention in Cirrhosis: A Role for Disregulated Proteolysis by Proprotein Convertases?

Liver International Communications, Volume 6, Issue 2, June 2025.
ABSTRACT Loss of effective arterial blood volume, secondary hyperaldosteronism, adrenergic activation and nonosmotic hypersecretion of vasopressin induce sodium and water retention in cirrhotic patients with ascites. The mechanisms of sodium retention that precede ascites formation remain elusive.
Giovanni Sansoè, Manuela Aragno, Florence Wong   +2 more
wiley   +1 more source

Prorenin Accumulation and Activation in Human Endothelial Cells

, 2001
—ACE inhibitors improve endothelial dysfunction, possibly by blocking endothelial angiotensin production. Prorenin, through its binding and activation by endothelial mannose 6-phosphate (M6P) receptors, may contribute to this production.
Maarten A. D. H. Schalekamp, Mark M. E. D. van den Eijnden, Jasper J. Saris, Elly de Wit, René J. A. de Bruin, Wim Sluiter, A. H. Jan Danser, Timothy L. Reudelhuber, Frans H. M. Derkx   +8 more
core   +1 more source

Adrenal (Pro)renin Receptor Expression and Serum Soluble (Pro)renin Receptor Concentration in Primary Aldosteronism

International Journal of Endocrinology, 2020
The (pro)renin receptor [(P)RR] is a multifunctioning protein playing roles in various pathological conditions. A soluble form of (P)RR [s(P)RR] has been considered a biomarker for (P)RR expression in tissues.
Daisuke Watanabe, Satoshi Morimoto, Noriko Morishima, Yoichiro Kato, Yoji Nagashima, Noriyuki Shibata, Atsuhiro Ichihara   +6 more
doaj   +1 more source

Prorenin renin and insulin resistance

Frontiers in Bioscience, 2010
Recently we showed that fructose feeding in rats induced nonproteolytic activation of prorenin and subsequent angiotensin II production in skeletal muscle. In addition, a pharmacological inhibitor of prorenin/(pro)renin receptor interaction attenuated the development of insulin resistance.
Kazi, Rafiq, Yukiko, Nagai, Daisuke, Nakano   +2 more
openaire   +2 more sources

(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet–Induced Hepatic Steatosis

Biomolecules, 2023
Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism ...
Ariana Julia B. Gayban, Lucas A. C. Souza, Silvana G. Cooper, Erick Regalado, Robert Kleemann, Yumei Feng Earley   +5 more
doaj   +1 more source

Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials

Health Science Reports, Volume 8, Issue 3, March 2025.
ABSTRACT Background and Aims Hypertension exacerbates cardiovascular risks in patients with type 1 diabetes mellitus (T1DM), necessitating effective blood pressure (BP) management. Vitamin D deficiency is common in T1DM patients and is associated with an increased risk of cardiovascular diseases.
Rasoul Ebrahimi, Mohammad Mahdi Masouri, Amir Abbas Salehi Amniyeh Khozani, Sana Mohammad Soltani, Seyed Aria Nejadghaderi   +4 more
wiley   +1 more source