Results 51 to 60 of about 2,480 (301)

Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review

Frontiers in Cardiovascular Medicine, 2020
Although clinical manifestations of the 2019 novel coronavirus disease pandemic (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), are mainly respiratory symptoms, patients can also develop severe cardiovascular
Annamaria Mascolo, Annamaria Mascolo, Cristina Scavone, Cristina Scavone, Concetta Rafaniello, Concetta Rafaniello, Carmen Ferrajolo, Carmen Ferrajolo, Giorgio Racagni, Liberato Berrino, Giuseppe Paolisso, Francesco Rossi, Francesco Rossi, Annalisa Capuano, Annalisa Capuano   +14 more
doaj   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Therapeutic targets of renin-angiotensin system in ocular disorders

Journal of Current Ophthalmology, 2017
Purpose: To review current literature on the renin-angiotensin system (RAS)-mediated pathogenic mechanisms and therapeutic targets in ocular diseases.
Rajesh Choudhary, Mandeep Singh Kapoor, Amrita Singh, Surendra H. Bodakhe   +3 more
doaj   +1 more source

Enzymatic formation of angiotensins II and III in the hindlimb circulation of dogs

, 1987
Experiments were performed in 14 anesthetized dogs to (1) to determine if the reductions in hindlimb blood flow produced by [des-Asp1] angiotensin I were due to its local enzymatic (kininase II) conversion to angiotensin III and (2) to quantitate the ...
Patricia J. Metting, Steven L. Britton
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Interplay between brain stem angiotensins and monocyte chemoattractant protein-1 as a novel mechanism for pressor response after ischemic stroke

Neurobiology of Disease, 2014
Pressor response after stroke commonly leads to early death or susceptibility to stroke recurrence, and detailed mechanisms are still lacking. We assessed the hypothesis that the renin–angiotensin system contributes to pressor response after stroke by ...
Alice Y.W. Chang, Faith C.H. Li, Chi-Wei Huang, Julie C.C. Wu, Kuang-Yu Dai, Chang-Han Chen, Shau-Hsuan Li, Chia-Hao Su, Re-Wen Wu   +8 more
doaj   +1 more source

Proteolytic processing of angiotensin-I in human blood plasma. [PDF]

PLoS ONE, 2013
In mammalian species, except humans, N-terminal processing of the precursor peptide angiotensin I (ANG-1-10) into ANG-2-10 or ANG-3-10 was reported. Here we hypothesize that aminopeptidase-generated angiotensins bearing the same C-terminus as ANG-1-10 ...
Diana Hildebrand, Philipp Merkel, Lars Florian Eggers, Hartmut Schlüter   +3 more
doaj   +1 more source

Bioactive angiotensin peptides: focus on angiotensin IV [PDF]

Journal of the Renin-Angiotensin-Aldosterone System, 2001
JRAAS 2001;2:205-10 Introduction The renin-angiotensin system (RAS) was initially identified as a circulating humoral system with the effector peptide,angiotensin II (Ang II),generated by an enzymatic cascade. Angiotensinogen, which is synthesised in the liver, is cleaved by renin,a product of the juxtaglomerular cells of the kidney, to form ...
T, Mustafa, J H, Lee, S Y, Chai, A L, Albiston, S G, McDowall, F A, Mendelsohn   +5 more
openaire   +2 more sources

Direct effects in vivo of angiotensins I and II on the canine sinus node

, 1991
The chronotropic responses to angiotensins I and II (5 μg in 1 mL Tyrode's solution) injected into the sinus node artery were assessed before and after the intravenous administration of captopril (2 mg/kg) and saralasin (20 μg/kg) in anaesthetized dogs.
R. Nadeau, P. Fortier, D. Godin, C. Lambert   +3 more
core   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source