Results 51 to 60 of about 2,698 (247)
, 2016 The heme peroxidase-catalyzed iodination of human angiotensins I and II is described. It is observed that lactoperoxidase (LPO) can effectively and selectively iodinate the tyrosyl residues in angiotensin peptides.
Bhaskar J. Bhuyan (2426848) +1 more
core +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
Therapeutic targets of renin-angiotensin system in ocular disorders
Journal of Current Ophthalmology, 2017 Purpose: To review current literature on the renin-angiotensin system (RAS)-mediated pathogenic mechanisms and therapeutic targets in ocular diseases.
Rajesh Choudhary +3 more
doaj +1 more source
, 2004 Using a highly sensitive fluorimetric assay, significant levels of angiotensin I -converting enzyme-like activity (ACELA) were detected in a range of tissues (branchial heart, gill, kidney with associated vasculature and archinephric duct, liver, whole ...
Thorndyke, Michael C., +8 more
core +1 more source
Advanced Science, EarlyView.Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang +11 more
wiley +1 more source
, 2006 Noradrenaline (NA) released by dendrites of locus coeruleus (LC) neurons controls LC neuron activity, and hence, NA released from noradrenergic fibers in terminal fields. NA synthesis is dependent on tyrosine hydroxylase (TH), whose dendritic presence is
Ogier, Michaël +5 more
core +2 more sources
Proteolytic processing of angiotensin-I in human blood plasma. [PDF]
PLoS ONE, 2013 In mammalian species, except humans, N-terminal processing of the precursor peptide angiotensin I (ANG-1-10) into ANG-2-10 or ANG-3-10 was reported. Here we hypothesize that aminopeptidase-generated angiotensins bearing the same C-terminus as ANG-1-10 ...
Diana Hildebrand +3 more
doaj +1 more source
Advanced Science, EarlyView.Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun +18 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 1997 A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be
H. Maldonado, A. Romano, D. Tomsic
doaj +1 more source
Site of Action of Angiotensin and other Vasoconstrictors on the Kidney
, 1971 Angiotensin II, angiotensin I, adrenaline, or noradrenaline was infused in rabbit kidneys isolated and perfused with oxygenated Krebs solution. Adrenaline increased the perfusion pressure and slightly decreased the filtration fraction and the glomerular
R. Gauthier, D. Regoli
core +1 more source