Results 31 to 40 of about 2,480 (301)
Frontiers in Cardiovascular Medicine, 2019 Angiotensin-(1-12) [Ang-(1-12)], an alternate substrate for tissue angiotensin II (Ang II) formation, underscores the importance of alternative renin-independent pathway(s) for the generation of angiotensins.
Carlos M. Ferrario +14 more
doaj +1 more source
The Role of Renin-Angiotensin-Aldosterone System in the Heart and Lung: Focus on COVID-19
Frontiers in Pharmacology, 2021 The renin-angiotensin-aldosterone system (RAAS) firstly considered as a cardiovascular circulating hormonal system, it is now accepted as a local tissue system that works synergistically or independently with the circulating one.
Annamaria Mascolo +16 more
doaj +1 more source
Angiotensins and Alzheimer's disease: a bench to bedside overview
, 2009 The pathology of Alzheimer's disease (AD) features amyloid beta peptide deposition, intracellular neurofibrillary tangles and deficits in the cholinergic pathway.
Kehoe, Patrick G
core +1 more source
G protein coupled receptors of the renin-angiotensin system: new targets against breast cancer?
Frontiers in Pharmacology, 2015 G-protein coupled receptors (GPCRs) constitute the largest family of membrane receptors, with high potential for drug discovery. These receptors can be activated by a panel of different ligands including ions, hormones, small molecules and vasoactive ...
Clara eNAHMIAS +1 more
doaj +1 more source
Perivascular Adipose Tissue in Vascular Function: Does Locally Synthesized Angiotensinogen Play a Role? [PDF]
, 2021 : In recent years, perivascular adipose tissue (PVAT) research has gained special attention in an effort to understand its involvement in vascular function.
Cruz-López, Edwyn O. +5 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Hospital Pharmacy, 2018 Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing ...
Danial E, Baker, Terri L, Levien
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension
International Journal of Hypertension, 2012 The classic renin-angiotensin system (RAS) was initially described as a hormone system designed to mediate cardiovascular and body water regulation. The discovery of a brain RAS composed of the necessary functional components (angiotensinogen, peptidases,
John W. Wright +2 more
doaj +1 more source
Frontiers in Endocrinology, 2014 Evidence for the potential role of organ specific cardiovascular renin-angiotensin systems (RAS) has been demonstrated experimentally and clinically with respect to certain cardiovascular and renal diseases.
Walmor eDe Mello, Edward D Frohlich
doaj +1 more source