Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]
, 2017 IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna +11 more
core +6 more sources
Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction [PDF]
, 2017 Exercise training reduces renin-angiotensin system (RAS) activation, decreases plasma and tissue oxidative stress and inflammation in hypertension. However, the temporal nature of these phenomena in response to exercise is unknown. We sought to determine
Casarini, Dulce E. +8 more
core +6 more sources
Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin [PDF]
, 2000 Angiotensin-(1-7) (Ang-(1-7)) increased osmotic water permeability in the isolated toad skin, a tissue with functional properties similar to those of the distal mammalian nephron. Concentrations of 0.1 to 10 μM were effective, with a peak at 20 min. This
Coviello, Alfredo +3 more
core +4 more sources
Diagnostics, 2023 Dipeptidyl amino-peptidase 3 (DPP3) is an aminopeptidase that is released into circulation upon cell death. DPP3 is involved in the degradation of angiotensins, enkephalines, and endomorphines.
Pasquale Innelli +11 more
doaj +1 more source
Anti-plasmodium activity of angiotensin II and related synthetic peptides. [PDF]
PLoS ONE, 2008 Plasmodium species are the causative agents of malaria, the most devastating insect-borne parasite of human populations. Finding and developing new drugs for malaria treatment and prevention is the goal of much research.
Ceres Maciel +6 more
doaj +1 more source
ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats [PDF]
, 2010 AngII (angiotensin II), ACE (angiotensin I-converting enzyme) and the AT(1) receptor (AngII type I receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia ...
Adriana K. Carmona +51 more
core +2 more sources
Effect of angiotensin converting enzyme (ACE) and angiotensins on human sperm functions
Andrologia, 2009 Summary The presence of components of the renin angiotensin system (RAS) and specific receptors of angiotensin II in the female and male reproductive tract supports the hypothesis that reproductive functions may be controlled by RAS.
F. Köhn +10 more
semanticscholar +1 more source
Journal of Molecular Medicine, 2008 Accumulation of a large body of evidence during the past two decades testifies to the complexity of the renin-angiotensin system (RAS). The incorporation of novel enzymatic pathways, resulting peptides, and their corresponding receptors into the biochemical cascade of the RAS provides a better understanding of its role in the regulation of ...
Varagic, Jasmina +4 more
openaire +3 more sources
Angiotensins and Alzheimer's disease: a bench to bedside overview
Alzheimer's Research & Therapy, 2009 The pathology of Alzheimer's disease (AD) features amyloid β peptide deposition, intracellular neurofibrillary tangles and deficits in the cholinergic pathway. Abnormal blood pressure is recognised as a risk factor for the development of AD, although the
P. Kehoe
semanticscholar +1 more source
Conversion and degradation of [125I] labelled angiotensin I in isolated perfused porcine coronary and carotid arteries [PDF]
, 1994 The aims were (1) to quantitate angiotensin I to II conversion on the endothelial surface and at deeper sites in isolated arteries, (2) to assess whether the angiotensin II that is formed at deeper sites is released into the vascular lumen, and (3) to ...
Chowdury, S. (Suchandana) +5 more
core +1 more source