Results 61 to 70 of about 8,818,903 (344)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
The Effect of Medication and Deep Brain Stimulation on Posture in Parkinson's Disease
Frontiers in Neurology, 2019 Introduction: Postural abnormalities are common in Parkinson's disease (PD) and increasing with disease progression. While many studies focus on balance and gait, postural alignment is only infrequently studied.Purpose: The aim of the present study was ...
Christian Schlenstedt +7 more
doaj +1 more source
A Two-Dimensional Precision Level for Real-Time Measurement Based on Zoom Fast Fourier Transform
Micromachines, 2023 This paper proposes a two-dimensional precision level for real-time measurement using a zoom fast Fourier transform (zoom FFT)-based decoupling algorithm that was developed and integrated in an FPGA.
Haijin Fu +8 more
doaj +1 more source
, 2011 X-ray polarisation measurement is a unique tool which may provide crucial information regarding the emission mechanism and the geometry of various astrophysical sources, like neutron stars, accreting black holes, pulsar wind nebulae, AGNs, Supernova ...
Maitra, Chandreyee, Paul, Biswajit
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Polynomial error approximation of a precision angle measuring system
Geodesy and Cartography, 2013 The paper deals with the calibration of a flat angle measuring system. The article describes a comparative method for using a multi-angular prism (polygon) with autocollimator along with an angle measuring system. The components of angle measuring system
Lauryna Šiaudinytė +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
SensorsThe paper proposes and verifies a small-angle measurement method based on the defect spot mode of the position-sensitive detector (PSD). With the output characteristics of the PSD in the defect spot mode and the size transformation properties of a ...
Yusheng Zhai +8 more
doaj +1 more source
Review of devices for measuring angles and prospects for development
Mokslas: Lietuvos Ateitis, 2010 The article analyzes the methods and devices for angle measurement. An accurate analysis of devices for angle measurement was performed. The accuracy of the angle position of the tested device was evaluated.
Giedrius Augustinavičius +1 more
doaj +1 more source
A Lens-Array-Based Measurement Technique for Spatial Angle
IEEE Access, 2022 Accurate measurement of the spatial angle is key for plane flatness and guide rail straightness detection. This paper presents a lens-array-based optical system and an analytical model for micro-spatial angle measurements.
Cunliang Cai +4 more
doaj +1 more source