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Adding a New Piece to the ASGR1 Puzzle: ANGPTL3
Arteriosclerosis, Thrombosis, and Vascular Biologyopenaire +2 more sources
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ANGPTL3: a novel biomarker and promising therapeutic target
Journal of Drug Targeting, 2019Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein that mainly expresses in the liver, and is regulated by numerous post-translational modifications, including multiple cleavage and glycosylation. Accumulating evidences have revealed that ANGPTL3 plays a critical role in both biological processes, such as lipid ...
Duanfang Liao, Li Qin, Zhe-Yu Hu
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Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
American Journal of Physiology-Endocrinology and Metabolism, 2021Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage. Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein lipase (LPL), thus LPL serves as a critical gatekeeper of fatty acid uptake into tissues.
Kelli L. Sylvers-Davie +1 more
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Angptl3 regulates lipid metabolism in mice
Nature Genetics, 2002The KK obese mouse is moderately obese and has abnormally high levels of plasma insulin (hyperinsulinemia), glucose (hyperglycemia) and lipids (hyperlipidemia). In one strain (KK/San), we observed abnormally low plasma lipid levels (hypolipidemia). This mutant phenotype is inherited recessively as a mendelian trait.
Ryuta, Koishi +7 more
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Factoring in ANGPTL3 When LDL Is Refractory
New England Journal of Medicine, 2020Patients with familial hypercholesterolemia, who have a severely increased low-density lipoprotein (LDL) cholesterol level from birth and are at high risk for premature cardiovascular disease, have...
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ANGPTL3 inhibition, dyslipidemia, and cardiovascular diseases
Trends in Cardiovascular MedicineOptimal management of low-density lipoprotein cholesterol (LDL-C) is a central tenet in the primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD). However, significant residual cardiovascular risk remains despite achieving guideline-directed LDL-C levels, in part due to mixed hyperlipidemia with elevated fasting and non ...
Fei, Luo +6 more
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