Results 121 to 130 of about 11,372 (280)

Construction of Candida albicans pRB895‐SAP2‐SC5314 With SAP2 High Expression and Its Effects on Adhesion

Journal of Clinical Laboratory Analysis, Volume 39, Issue 2, January 2025.
Our research successfully established the C. albicans strain with SAP2 overexpression (pRB895‐SAP2‐SC5314) using an improved lithium acetate conversion method. SAP2 overexpression may strengthen the pathogenicity of C. albicans through regulating the expression of adhesion‐related genes.
Lan Xue, Lu Yang, Bingqian Zhao, Wenli Feng, Jing Yang, Yan Ma   +5 more
wiley   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Molecular Identification and Antifungal Susceptibility of Fusarium spp. Clinical Isolates

Mycoses, Volume 68, Issue 1, January 2025.
ABSTRACT Background Accurate identification of Fusarium species requires molecular identification. Treating fusariosis is challenging due to widespread antifungal resistance, high rates of treatment failure, and insufficient information relating antifungal susceptibility to the clinical outcome.
Carla M. Román‐Montes, Fernanda González‐Lara, Paulette Diaz‐Lomelí, Axel Cervantes Sánchez, Andrea Rangel‐Cordero, José Sifuentes‐Osornio, Alfredo Ponce‐de‐León, Areli Martínez‐Gamboa   +7 more
wiley   +1 more source

Effectiveness and safety of echinocandins combination therapy with the standard of care compared to the standard of care monotherapy for the treatment of invasive aspergillosis infection: a meta-analysis

Frontiers in Pharmacology
BackgroundThis meta-analysis aims to evaluate the effectiveness and safety of combining echinocandins with standard of care (SOC) antifungal drugs for treating invasive aspergillosis infection (IAI).MethodWe searched PubMed, Embase, and Cochrane Library ...
Yazed Saleh Alsowaida, Bader Alshoumr, Shuroug A. Alowais, Khalid Bin Saleh, Alia Alshammari, Kareemah Alshurtan, Haytham A. Wali   +6 more
doaj   +1 more source

Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition [PDF]

, 2018
Candidiases are the most recurrent fungal infections, especially among immunosuppressed patients. Although Candida albicans is still the most widespread isolated species, non-Candida albicans Candida species have been increasing.
Arendrup MC, Célia F. Rodrigues, De Luca C, Grandesso S, Jabra-rizk MA, Maria Elisa Rodrigues, Mariana Henriques, Pappas PG, Pfaller MA, Williams DW   +9 more
core   +1 more source

Invasive candidiasis as a cause of sepsis in the critically ill patient. [PDF]

, 2013
Invasive fungal infections are an increasingly frequent etiology of sepsis in critically ill patients causing substantial morbidity and mortality. Candida species are by far the predominant agent of fungal sepsis accounting for 10% to 15% of health-care ...
Calandra, T., Delaloye, J.
core   +1 more source

Experience of using anidulafungin for treatment of invasive candidosis in patients after liver transplantation

Трансплантология (Москва), 2016
This article is an example of a successful treatment invasive fungal infections and bacterial infections caused by multidrug-resistant pathogen after liver ...
M. Sh. Khubutiya, N. K. Kuznetsova, S. V. Zhuravel, T. V. Chernenkaya, M. S. Novruzbekov, A. I. Bazhenov, I. I. Goncharova   +6 more
doaj  

Identification of Aspergillus cryptic species in hospital environment [PDF]

, 2015
Selected hospital wards, housing patients at higher risk to develop invasive fungal infections, were screened in order to understand the epidemiology and distribution of Aspergillus, especially regarding the presence of cryptic species.Aspergillus ...
Brandão, João, Clemons, K.V., Martins, C., Sabino, Raquel, Simões, H., Stevens, D.A., Veríssimo, C., Viegas, C.   +7 more
core   +1 more source

Successfully treated bilateral renal fungal balls with continuous Anidulafulgin irrigation

Urology Case Reports, 2021
A 73-year-old man with a history of type 2 diabetes mellitus, nephrolithiasis, and recurrent urinary tract infections caused by Candida glabrata was admitted to our hospital. Urosepsis was diagnosed and C.
N.A.M. van Merode, J.J. Pat, M.J.H.M. Wolfhagen, G.A. Dijkstra   +3 more
doaj  

Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation

Antimicrobial Agents and Chemotherapy, 2018
The echinocandins are a class of antifungal agents that target β-1,3-d-glucan (BG) biosynthesis. In the ascigerous Pneumocystis species, treatment with these drugs depletes the ascus life cycle stage, which contains BG, but large numbers of forms which ...
M. Cushion, A. Ashbaugh, K. Hendrix, M. Linke, Nikeya Tisdale, Steven G. Sayson, Aleksey A. Porollo   +6 more
semanticscholar   +1 more source